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Mixed live bacillus drops of bifidobacterium and lactobacillaceau and its prepn

A technology of Lactobacillus and Bifidobacteria, which is applied in the preparation of Lactobacillus mixed live bacteria drops, in the field of Bifidobacteria, can solve the problems of increasing the amount of dead bacteria and affecting drug efficacy, and achieves wide adaptability, stable biological properties, and resistance The effect of oxygen enhancement

Inactive Publication Date: 2004-09-01
卢放根
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Problems solved by technology

In the past, vaginal microecological preparations were single strains, and their effects were mostly limited to the treatment of bacterial vaginosis, and most of them were suppositories. During the production process, glycerin and other compressive agents needed to be added at a higher temperature, which would increase the amount of dead bacteria and affect the efficacy of the drug. effect

Method used

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Embodiment Construction

[0006] In the present invention, according to the prior art, the microecological preparations are all single strains, have a narrow scope of action, poor effect, and are difficult to adapt to the defects of modern professional production. Lactobacillus with strong antibacterial ability and good anti-inflammatory effect and anti-tumor Bifidobacteria and immunomodulatory effects of bifidobacteria, after many experiments, were isolated and identified from the vaginal vault of young healthy women, one strain of bifidobacteria and one strain of lactobacillus, after in vitro mutagenesis culture and domestication, the oxygen resistance ability was enhanced, and the biological characteristics It is more stable and suitable for industrial production, and then it is made by adding an appropriate amount of dispersant for quick freeze-drying. The separation method of Bifidobacterium and Lactobacillus bacterial strains of the present invention is to take 0.2ml of the vaginal fornix secretio...

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Abstract

The mixed live bacillus drops are prepared by separating and identifying one strain of bifidobacterium and one strain of lactobacillaceau from vagina vault of some young and healthy women and through in vitro mutagenesis and culture, oxytolerant acclimation, adding dispersant and freeze drying. During the preparation, the strains are increased in PYG anaerobic bacillus culture medium to 10 to the power 9 to 10 the power 11 / ml over density; the bacillus liquid is mixed with skimmed milk, cane sugar dispersant, glutin and glycerine excipient; the mixture is frozen in -80 deg.c for 30-60 min, freeze dried at -30 to 70 deg.c within 22-26 hr; and the two kinds of live bacillus powder are mixed and made into pills. The strains of the present invention is stable, no drug resistance and oxytolerant, and has the infection resisting effect, wide bacteriostasis spectrum and antineoplastic immunoregulating effect; and is suitable for industrial production.

Description

technical field [0001] The invention relates to a western medicine preparation, in particular to a method for preparing bifidobacteria and lactobacillus mixed live bacteria drops for preventing and treating various specific and non-specific gynecological inflammations and gynecological tumors. Background technique [0002] The current theory of western medicine points out that the imbalance of vaginal micro-ecological environment is the main cause of various gynecological inflammations, and the occurrence of some gynecological tumors is also related to it. How to restore and maintain vaginal micro-ecological balance is a hot spot of current research. In the past, vaginal microecological preparations were single strains, and their effects were mostly limited to the treatment of bacterial vaginosis, and most of them were suppositories. During the production process, glycerin and other compressive agents had to be added at a higher temperature, which would increase the amount of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/745A61K35/747A61P15/02
Inventor 卢放根
Owner 卢放根
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