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Ginkgo lactone capsule and its prepn. method

The technology of ginkgolide and soft capsule is applied in the field of ginkgolide pharmaceutical preparation, which can solve the problem of ginkgolide being insoluble in water and the like, and achieve the effects of simple preparation method, good stability and good therapeutic effect.

Inactive Publication Date: 2004-08-04
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But report to the dosage form of ginkgolide is seldom at present, because ginkgolide itself is difficult to dissolve in water, so adopt soft capsule as administration form and have not yet been reported at present

Method used

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  • Ginkgo lactone capsule and its prepn. method

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Comparison scheme
Effect test

Embodiment 1

[0019] Composition of medicinal liquid materials: ginkgolide 100g, soybean oil 450g, beeswax 10g;

[0020] Capsule shell material composition: gelatin 100g, glycerin 43g, water 102g, paraffin methyl ester 0.18g, parasol

[0021] Ethyl ester 0.1g.

[0022] Preparation method: put beeswax in soybean oil, heat until melted, let cool to room temperature, add ginkgolide, stir well with a colloid mill to obtain a liquid medicine; take gelatin, glycerin, water, put in a suitable container and heat to 80 Dissolve at ℃, filter, add the filtrate to the paradigin methyl ester and paraben ethyl ester, mix well, and keep warm at 60°C to obtain the rubber solution; take the above-mentioned medicinal liquid and rubber solution, press them with soft capsule production equipment, and after drying Promptly get the ginkgolide soft capsule of the present invention.

Embodiment 2

[0024] Composition of liquid medicine materials: ginkgolide 40g, soybean oil 200g, beeswax 6g;

[0025] Capsule shell material composition: 50g gelatin, 20g glycerin, 51g water, 0.1g paradoxine methyl ester, paradoxine B

[0026] Esters 0.08g.

[0027] Preparation method: take beeswax and put it in soybean oil, heat it until it melts, let it cool to room temperature, add ginkgolide, stir it with a colloid mill, and get the medicine liquid; take gelatin, glycerin, water, put it in a suitable container and heat it to 80 Dissolve at ℃, filter, add paralyzed methyl ester and paralyzed ethyl ester to the filtrate, mix well, and keep warm at 60°C to obtain a rubber solution; take the above-mentioned medicinal liquid and rubber solution, press them with soft capsule production equipment, dry, Ready to serve. Pharmacodynamic Study of Ginkgolide Soft Capsules on Ischemic Stroke

[0028] 1. Effect of Ginkgolide Soft Capsules (hereinafter referred to as GTL) on cerebral ...

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Abstract

The present invention discloses a bilobalide soft capsule formed from two portions of liquid medicine and capsule shell, in which the liquid medicine is formed from bilobalide, vegetable oil and bee wax, and the capsule shell is made up by using gelatin, water, glycerin and antiseptic nipagin. Said invention also discloses its preparation method, said product possesses good stability, and can obtain good therapeutic effect for curing apoplexy and coronary heart disease.

Description

Technical field [0001] The invention relates to a ginkgolide pharmaceutical preparation, more specifically to a ginkgolide soft capsule, and simultaneously the invention also relates to a preparation method of the preparation. Background technique [0002] There are many studies on Ginkgo biloba extract at home and abroad. Its production process, pharmacological research and clinical application are relatively mature, and there are many market products, such as Ginkgo biloba extract capsules and tablets successfully developed by Shanghai Institute of Materia Medica, Chinese Academy of Sciences. It is clinically used in cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, cerebral arteriosclerosis, and cerebral arteriosclerosis and insufficient cerebral blood supply. The company's clinical trial of Ginkgo biloba extract for the prevention and treatment of Alzheimer's disease in the United States has also been successful. The side effect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K31/365A61P9/10
Inventor 张平
Owner 张平
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