Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of dental pulp stem cells in preparation of medicine for treating multiple sclerosis

A technology of multiple sclerosis and dental pulp stem cells, applied in the field of biomedicine, to achieve the effect of easy acquisition, inhibition of central inflammation, and reduction of spinal cord demyelination lesions

Pending Publication Date: 2022-08-09
BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its application in central nervous system diseases has not been reported yet.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of dental pulp stem cells in preparation of medicine for treating multiple sclerosis
  • Application of dental pulp stem cells in preparation of medicine for treating multiple sclerosis
  • Application of dental pulp stem cells in preparation of medicine for treating multiple sclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0042] Example: Clinical symptoms and detection of demyelinating lesions and brain inflammation in EAE model mice

[0043] 1. Experimental animals: C57 / BL6 mice, 10 weeks old, female, were randomly divided into 4 groups of 10 mice, respectively:

[0044] Sham operation group Control group (Sham+Vehicle): Administer normal saline after sham operation:

[0045] Sham operation group and administration group (Sham+DPSC): dental pulp stem cell suspension was administered after sham operation;

[0046] Model group Control group (EAE+Vehicle): After modeling, normal saline was given:

[0047] Model group administration group (EAE+DPSC): dental pulp stem cell suspension was administered after modeling;

[0048] Preparation of dental pulp stem cell suspension: dental pulp stem cells were prepared at 1 × 10 6 The concentration per mL was dissolved in normal saline.

[0049] 2. Animal experiment method:

[0050] 2.1 Model establishment:

[0051] The mouse polypeptide antigen MOG35-...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to application of dental pulp stem cells in preparation of a medicine for treating multiple sclerosis. The embodiment of the invention provides application of dental pulp stem cells in preparation of a medicine for treating multiple sclerosis. The dental pulp stem cells are simple and convenient to obtain, easy to amplify in vitro and high in multiplication capacity, and have clinical application advantages compared with other human body mesenchymal stem cells. Research shows that the dental pulp stem cells can obviously reduce EAE mouse spinal cord demyelination focus, reduce the injury area around the ventricle and reduce demyelination injury; in addition, immune cell infiltration in the brain can be obviously reduced, T cell infiltration is reduced, and central inflammation is inhibited.

Description

Technical field [0001] The present invention belongs to the field of biomedicine technology, and specifically relates to the application of dental pulp stem cells in preparing drugs for multiple sclerosis. Background technique [0002] Multiple sclerosis (MS) is an autoimmune disease involving the central nervous system mediated by activated CD4+ T cells. Its main immune mechanism is that peripheral lymphocytes enter the CNS and cause irreversible inflammation of nerve fibers. Demyelinating changes and axonal damage. Traditional drugs for the treatment of MS include Copaxone, interferon beta, etc., which have mild side effects but not significant efficacy. Newly approved drugs by the U.S. FDA, such as Natalizumab and Fingolimod, have significant effects on MS. These drugs reduce neuroinflammation by inhibiting lymphocyte adhesion or migration, but may cause progressive neuroinflammation. Serious complications such as multifocal leukoencephalopathy and sudden cardiac death....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K35/28A61P25/00A61P29/00A61P37/02
CPCA61K35/28A61P25/00A61P29/00A61P37/02
Inventor 王松灵周建施福东金薇娜王昊
Owner BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com