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Methods and compositions for cosmetic and cosmetic treatment and stimulation of hair growth

A technology of composition and lysate, applied in the fields of biochemical equipment and methods, microorganisms, hair care, etc., can solve the problems of reduced expression of protective proteins, damaged skin barrier, etc.

Pending Publication Date: 2022-08-05
普拉里生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This may be due to a genetic polymorphism that results in decreased expression of protective proteins and thus compromises the skin barrier

Method used

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  • Methods and compositions for cosmetic and cosmetic treatment and stimulation of hair growth
  • Methods and compositions for cosmetic and cosmetic treatment and stimulation of hair growth
  • Methods and compositions for cosmetic and cosmetic treatment and stimulation of hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0252] Example 1: Culture and Production of Adherent Placental Cells

[0253] Placenta-derived cell populations containing more than 90% maternal tissue-derived cells were prepared as described in Example 1 of International Patent Application WO 2016 / 098061, which is incorporated herein by reference in its entirety.

Embodiment 2

[0255] Example 2: Culture of placental cells in serum-free medium (SFM)

[0256] method

[0257] The cell harvest and expansion process consists of 3 stages followed by downstream processing steps: Stage 1 , Intermediate Cell Stock (ICS) production; Stage 2 , thaw the ICS and proceed to the initial further incubation steps; and Stage 3 , an additional incubation step was performed in the presence of serum. Downstream processing steps include harvesting from flasks or bioreactors, cell concentration, washing, formulation, filling, and cryopreservation. This procedure involves periodic testing of the growth medium for sterility and contamination, all of which are described in International Patent Application Publication No. WO 2019 / 239295, which is incorporated herein by reference. Bone marrow migration assays were also performed as described in WO 2019 / 239295.

[0258] result

[0259] Placental cells were extracted and expanded in serum free (SF) medium for 3 passages....

Embodiment 3

[0262] Example 3: Osteocyte and Adipocyte Differentiation Assay

[0263] ASCs were prepared as described in Example 1 . BM adherent cells were obtained as described in WO2016 / 098061 by Esther Lukasiewicz Hagai and Rachel Ofir, which is hereby incorporated by reference in its entirety. Osteogenesis and adipogenesis assays were performed as described in WO 2016 / 098061.

[0264] Osteocyte induction. Incubation of BM-derived adherent cells in osteogenesis-inducing medium resulted in more than 50% differentiation of BM cells, as evidenced by positive Alizarin Red staining. In contrast, none of the placenta-derived cells showed signs of osteogenic differentiation.

[0265] Next, a modified osteogenesis medium containing vitamin D and a higher concentration of dexamethasone was used. More than 50% of BM cells underwent differentiation into osteocytes, and none of the placenta-derived cells showed signs of osteogenic differentiation.

[0266] Adipocyte induction. In adipocyte indu...

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Abstract

Disclosed herein are methods and compositions for treating skin conditions (e.g., damaged skin barrier, acne, wrinkles, hyperpigmentation / insufficiency, dryness, elastic tissue degeneration), increasing skin volume, and preventing or treating baldness and related conditions, the compositions comprise placental adherent stromal cells, conditioned media derived from cultured placental ASC, lysates thereof, and fractions thereof.

Description

[0001] This application is a divisional application of Chinese Patent Application No. 202080011846.9 filed on March 26, 2020, entitled "Methods and Compositions for Cosmetic and Cosmetic Treatment and Stimulating Hair Growth". technical field [0002] Disclosed herein are methods and compositions for stimulating hair growth and aesthetic and cosmetic treatments comprising placenta-derived adherent stromal cells and factors derived therefrom. Background technique [0003] Skin aging is a multi-system degenerative process involving the skin and the skin support system (Sjerobabski & Poduje, 2008). The process of skin aging can be divided into intrinsic aging and extrinsic aging. It can be caused by several factors, such as UV irradiation, stress, ROS production or smoking. The formation of wrinkles is characteristic of photoaging skin and can be caused by the degradation of collagen fibrils and gelatin fibers. Furthermore, due to increased melanin synthesis, hyperpigmented s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/98A61Q19/00A61Q19/08A61K35/50A61P17/10A61P17/14A61P17/18A61P17/00A61L27/38A61L27/50
CPCA61K8/99A61K8/982A61Q19/00A61Q19/08A61Q19/007A61K35/50A61P17/10A61P17/14A61P17/18A61P17/00A61L27/3804A61L27/50A61K2800/91A61L2400/06A61P17/02A61Q19/02A61Q7/00C12N5/0605C12N2500/99A61K9/0019A61L27/3604A61K9/06A61K9/122C12N2513/00
Inventor Y·亚娜L·拉维夫M·阿加西S·莫兰
Owner 普拉里生物科技有限公司
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