Method for capturing biological sample based on continuous domain quasi bound state terahertz metasurface tweezers

A biological sample and metasurface technology, applied in the field of terahertz spectroscopy, can solve the problem of low electric field localization of terahertz wave devices, and achieve the effect of improving non-destructive capture and manipulation capabilities and high electric field enhancement

Pending Publication Date: 2022-08-02
XI AN JIAOTONG UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a method for capturing biological samples based on continuum quasi-bound state terahertz metasurface tweezers, using terahertz waves instead of laser, visible light or infrared. It has a very high biocompatibility and will not cause damage to biological samples; by using metasurface tweezers based on continuous domain quasi-bound states to improve the localization and enhancement of the electric field, the localization of the electric field of the terahertz wave device is improved. High disadvantage, increases the binding force that captures particles can provide, thus increasing the capture capacity

Method used

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  • Method for capturing biological sample based on continuous domain quasi bound state terahertz metasurface tweezers
  • Method for capturing biological sample based on continuous domain quasi bound state terahertz metasurface tweezers
  • Method for capturing biological sample based on continuous domain quasi bound state terahertz metasurface tweezers

Examples

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Embodiment 1

[0074] see figure 2 , is the unit geometry model of Example 1, which consists of two vertical bars and a cuboid base. All components are made of silicon with a dielectric constant of 11.9, which is the smallest unit and is periodically arrayed in the plane, that is, obtain a quasi-bound state-enhanced terahertz metasurface tweezers (see image 3 ), in practice, at least the area of ​​the metasurface tweezers needs to be larger than the area of ​​the terahertz spot (2 square millimeters), and considering the processing problem, the number of arrays is 15*15~50*50.

[0075]The geometrical dimensions of the terahertz metasurface tweezers ranged from P=85-95 μm, H=35-50 μm, W=30-35 μm, L=50 μm, ΔL=-30-30 μm. The CST Studio Suite electromagnetic simulation software is used to calculate the reflection spectrum of the incident electromagnetic wave in the range of 1.095 to 1.115 THz, the polarization direction of the incident electromagnetic wave is parallel to the vertical direction...

Embodiment 2

[0082] see Figure 7 , is a schematic diagram of the unit structure of Example 2, which is shaped like a hole-digging square, and the composition material is gold; the geometric dimensions are in the order of P=240~260μm, H=20~25μm, S=140~160μm, W=40~ 50μm, L=35~45μm, ΔY=-50~50μm.

[0083] see Figure 8 , Figure 8 Absorption spectrum contour plots are shown for frequencies ranging from 2.9 to 2.935 THz and ΔY from -50 to 50 μm.

[0084] see Figure 9 , and its corresponding Q value, when ΔY=0 is an obvious bound state excitation point.

[0085] Preferably, the dimensions P=250 μm, H=20 μm, S=150 μm, W=44 μm, L=40 μm, and ΔY=30 μm are used as the terahertz metasurface tweezers of Example 2.

[0086] see Figure 10 , for the preferred quasi-bound state terahertz metasurface tweezers (ΔY = 30 μm), when the resonant frequency is 2.9221 terahertz, the electric field forms a relatively high electric field around the rectangle and inside the square hole, especially at the corn...

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Abstract

The invention discloses a method for capturing a biological sample based on continuous domain quasi-bound state terahertz metasurface tweezers. The terahertz metasurface tweezers excited in a quasi-bound state are designed for particles to be captured; dropwise adding a solution containing biological sample particles to be captured on the surface of the designed metasurface tweezers; adjusting the relative angle between the metasurface tweezers and the polarization direction of the terahertz wave, irradiating the terahertz wave, and forming an electric field local area in a specific area of the metasurface tweezers; capturing potential wells are locally generated by the electric field, and biological sample particles in the area are captured by gradient force generated by the potential wells. According to the terahertz metasurface tweezers, quasi-bound state excitation is achieved in the terahertz wave band, very high electric field enhancement and localization can be achieved, and therefore the lossless capturing and control capacity of biological sample particles is improved.

Description

technical field [0001] The invention belongs to the technical field of terahertz spectroscopy, and in particular relates to a method for capturing biological samples based on continuous-domain quasi-bound state terahertz metasurface tweezers. Background technique [0002] In the field of biomedicine, it is often necessary to capture and precisely position biological samples such as molecules, viruses, and cells at the nanometer and micrometer scales, such as binding certain chemical molecules to specific cellular receptors. The usual technical route is to use fluorescent agents, radionuclides and other substances to first modify and label biological samples, and then artificially manipulate and transport them to specific sites. These methods not only cannot achieve non-contact and may contaminate biological samples, the labeling process is cumbersome, but also it is difficult to accurately and efficiently capture and manipulate target biological samples, which greatly limits...

Claims

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Application Information

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IPC IPC(8): G21K1/00
CPCG21K1/006G21K1/003
Inventor 张留洋殷玮沈忠磊李文康李胜男王中兴韩东海
Owner XI AN JIAOTONG UNIV
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