Application of dammarendiol in preparation of medicine for preventing and treating autoimmune hepatitis

A dammarediol, autoimmune technology, applied in the field of medicine, can solve the problems of low bioavailability, difficult absorption of ginsenosides and the like

Pending Publication Date: 2022-07-26
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ginsenoside itself is not easily absorbed, and its bioavailability is low

Method used

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  • Application of dammarendiol in preparation of medicine for preventing and treating autoimmune hepatitis
  • Application of dammarendiol in preparation of medicine for preventing and treating autoimmune hepatitis
  • Application of dammarendiol in preparation of medicine for preventing and treating autoimmune hepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 The effect of dammarediol on mouse liver injury caused by concanavalin A

[0017] 1. Animal group administration and modeling

[0018] 30 healthy mice were weighed and divided into three groups according to body weight by simplified random method, namely normal group, model group and dammarediol group. After the grouping was completed, the normal group and model group were intraperitoneally injected with 10 mL / kg of sodium chloride injection, and the dammarediol group was intraperitoneally injected with 400 mg / kg of dammarediol, once a day for seven consecutive days. One hour after the seventh administration, the mice were weighed, and the normal group was injected with 10 mL / kg sodium chloride injection through the tail vein, and the other groups were injected with 18 mg / kg concanavalin A through the tail vein to establish models. Administered once 3 hours after modeling, the normal group and model group were intraperitoneally injected with 10 mL / kg sodium c...

Embodiment 2

[0037] Example 2 Therapeutic effect of dammarediol on autoimmune hepatitis rats

[0038] A rat model of autoimmune hepatitis developed significant immune balance disorders, manifested by CD4 + Increased cell percentage, increased Th2 cytokine levels, decreased Thl cytokine levels, and increased hepatocyte-specific lipoprotein antibody levels lead to the development of autoimmune hepatitis. of which CD4 + Cell infiltration in liver tissue and release can lead to liver injury. The imbalance of Thl and Th2 cell activity and its cytokine balance is one of the main causes of autoimmune tissue damage. IL-6 promotes the release of acute phase proteins when inflammatory response is also caused. Causes of liver tissue damage.

[0039] 1. Preparation of autoimmune hepatitis rat model:

[0040] Wistar rats, male, 3 months old. Freund's complete adjuvant plus hepatocyte-specific lipoprotein 2 mg per animal was injected into the neck, axilla, groin, intraperitoneal cavity and muscle at...

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Abstract

The invention belongs to the field of medicines, and relates to application of dammarendiol, in particular to application of dammarendiol in preparation of drugs for preventing and treating autoimmune hepatitis. The research result of the effect of the dammarendiol on mouse liver injury caused by concanavalin A shows that the dammarendiol can obviously reduce the content of transaminase and the liver index of an autoimmune hepatitis model mouse; the research result of the treatment effect of the dammarendiol on rats with autoimmune hepatitis shows that the dammarendiol can obviously improve the proportional imbalance between the level of interleukin and the level of gamma-interferon, obviously increase the level of interleukin 2 and the level of gamma-interferon, and reduce the level of interleukin 4 and the level of interleukin 6; the traditional Chinese medicine composition has a remarkable prevention and treatment effect on autoimmune hepatitis.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of dammarenediol, in particular to the use of dammarenediol in the preparation of a drug for preventing and treating autoimmune hepatitis. Background technique [0002] Ginseng is a world-famous medicinal plant. my country has used ginseng to prevent and treat diseases for thousands of years and has accumulated rich experience. Ginseng is a plant of the Araliaceae family. With the continuous development of cultivation and processing technology, the medicinal value of ginseng has been paid more and more attention by people. Modern scientific research has proved that ginseng has a wide range of effects on the central nervous system, cardiovascular, digestive tract, endocrine, material metabolism and urogenital system. It also has anti-stress effects, improves the body's adaptability, enhances the body's immunity and anti-aging and so on. In recent years, the application of ginseng in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P37/02A61P1/16
CPCA61K31/575A61P37/02A61P1/16
Inventor 张贵民李玉婷潘思娜
Owner SHANDONG NEWTIME PHARMA
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