Application of tilianin in preventive protection medicine for abdominal aortic aneurysm

Abstract

The invention provides application of tilianin in a preventive protection medicine for abdominal aortic aneurysm, and belongs to the technical field of life science and medicine. The invention provides an application of tilianin in preparation of a preventive protective drug for abdominal aortic aneurysm, and researches find that tilianin can reduce the aorta diameter change rate, inhibit expansion of abdominal aorta and restore animal weight; the degradation and fracture degree of the elastic fiber is obviously reduced, and the natural appearance of the elastic fiber is recovered to a certain extent; the tilianin can significantly reduce inflammatory cells of vascular walls and inhibit the occurrence of inflammatory reactions; the degradation of collagen fibers on the wall of the abdominal aortic aneurysm is inhibited; the protein level of the MMP2 / 9 can be reduced, and the gene transcription of the MMP2 / 9 can be inhibited.

Description

technical field [0001] The invention relates to the fields of life science and medical technology, in particular to the application of terinoside in a preventive and protective medicine for abdominal aortic aneurysm. Background technique [0002] Abdominal aortic aneurysm (AAA) is a local permanent dilated lesion of the abdominal aorta, which mostly occurs in the infrarenal abdominal aorta. Abdominal aortic aneurysm usually has an insidious onset, no obvious symptoms at first, and the patient is not easily aware of it. If it is not detected and controlled as soon as possible, it is allowed to develop naturally. The final consequence is the continuous expansion of the tumor until it ruptures. Once ruptured, its mortality rate up to 80%. At present, the clinical intervention methods for abdominal aortic aneurysm are mainly traditional open surgery and endovascular repair, both of which are surgical interventions, which are traumatic and economical for patients, and there is a...

AI Technical Summary

Problems solved by technology

Studies have shown that stellin can resist myocardial ischemia-reperfusion injury (Myocardial ischemia-reperfusion injury, MIRI) by resisting oxidative damage, reducing inflammation, increasing ATP production in cardiomyocytes, and protecting the structure and function of mitochondria. However, the preventive protective effect of tianinin on abdominal aortic aneurysm has not been studied

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