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Preparation method of cyclodextrin metal organic framework stably existing in water phase

A metal-organic framework and cyclodextrin technology, which is applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc., can solve the problem of poor solubility of active substances, low bioavailability, and cyclodextrin Metal-organic framework inclusion complexes are unstable and other problems, and achieve the effects of poor solubility, high biocompatibility and good biocompatibility

Active Publication Date: 2022-06-24
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a kind of preparation method of the water-insoluble cyclodextrin metal-organic framework loaded active substance, to solve the poor solubility of some active substances in water , low bioavailability and instability of cyclodextrin MOF clathrates in water

Method used

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  • Preparation method of cyclodextrin metal organic framework stably existing in water phase
  • Preparation method of cyclodextrin metal organic framework stably existing in water phase
  • Preparation method of cyclodextrin metal organic framework stably existing in water phase

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation of glycidin-loaded β-CD-MOF / Tween 80 complex

[0033] (1) Reaction: 0.4254g of β-cyclodextrin and 0.168g of solid potassium hydroxide were dissolved in 15ml of deionized water, magnetically stirred at room temperature for 30min, sonicated for 10min, weighed 9ml of methanol and added to the solution, and continued stirring 5min, the solution was mixed evenly.

[0034] (2) Filtration: The above solution was filtered through a 0.45 μm PTFE filter membrane and placed in a small glass beaker.

[0035] (3) Steam diffusion: place a small glass beaker in a large beaker filled with 50 ml of methanol, seal the large beaker with pressure-sensitive adhesive, and place it in a magnetic field generator for 4 hours. In the electric heating constant temperature circulating water tank, in the constant temperature water tank at 50 ℃, methanol slowly diffuses into the prepared mother liquor, and the energy of the magnetic field causes the rapid formation of crystal...

Embodiment 2

[0042] Example 2: Preparation of naringenin-loaded β-CD-MOF / Tween 80 inclusion complex

[0043] (1) Reaction: 0.4254g of β-cyclodextrin and 0.168g of solid potassium hydroxide were dissolved in 15ml of deionized water, magnetically stirred at room temperature for 30min, sonicated for 10min, weighed 9ml of methanol and added to the solution, and continued stirring 5min, the solution was mixed evenly.

[0044] (2) Filtration: The above solution was filtered through a 0.45 μm PTFE filter membrane and placed in a small glass beaker.

[0045] (3) Steam diffusion: place a small glass beaker in a large beaker filled with 50 ml of methanol, seal the large beaker with pressure-sensitive adhesive, and place it in a magnetic field generator for 4 hours. In the electric heating constant temperature circulating water tank, in the constant temperature water tank at 50 ℃, methanol slowly diffuses into the prepared mother liquor, and the energy of the magnetic field causes the rapid formatio...

Embodiment 3

[0052] Example 3: Preparation of cinnamaldehyde-loaded β-CD-MOF / Tween 80 inclusion complex

[0053] (1) Reaction: 0.4254g of β-cyclodextrin and 0.168g of solid potassium hydroxide were dissolved in 15ml of deionized water, magnetically stirred at room temperature for 30min, sonicated for 10min, weighed 9ml of methanol and added to the solution, and continued stirring 5min, the solution was mixed evenly.

[0054] (2) Filtration: The above solution was filtered through a 0.45 μm PTFE filter membrane and placed in a small glass beaker.

[0055] (3) Steam diffusion: place a small glass beaker in a large beaker filled with 45ml of methanol, seal the large beaker with pressure-sensitive adhesive, and place it in a magnetic field generator for 4 hours, then place the large beaker in an electric heating constant temperature circulating water tank and place it in a closed place. In the electric heating constant temperature circulating water tank, methanol slowly diffuses into the prep...

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Abstract

The invention discloses a preparation method of a cyclodextrin metal organic framework stably existing in a water phase, which comprises the following steps: reaction: dissolving beta-cyclodextrin and potassium hydroxide solid in deionized water, carrying out magnetic stirring and ultrasonic treatment at room temperature, adding methanol, and stirring to uniformly mix the solution; filtering: filtering the solution through a PTFE (Polytetrafluoroethylene) filter membrane, and putting the solution into a small glass beaker; steam diffusion: placing the small glass beaker in methanol steam to form a beta-CD-MOF crystal; taking out the crystal, washing with ethanol, and centrifuging; performing vacuum drying to obtain beta-CD-MOF (Metal Organic Framework); preparing a beta-CD-MOF inclusion compound loaded with an active substance by adopting an impregnation method; the preparation method comprises the following steps: preparing a beta-CD-MOF / Tween 80 compound which is stable in a water phase and is loaded with an active substance by adopting a physical adsorption modification method; washing with absolute ethyl alcohol, and placing the washed precipitate in a small beaker; and carrying out vacuum drying to obtain the Tween 80 modified beta-CD-MOF loaded with the active substance.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a preparation method of a cyclodextrin metal-organic framework stable in an aqueous phase. Background technique [0002] At present, bioactive ingredients have received extensive attention, but some natural active substances existing in nature have their unstable properties, such as poor solubility in water, poor sensitivity to digestive environment, and low absorption rate in vivo, which seriously restrict the use of active substances. Applications in the food and pharmaceutical industries. Therefore, it is imperative to improve the solubility of hydrophobic active substances and develop edible delivery systems for bioactive substances. [0003] Metal Organic Frameworks (MOFs) are porous materials that have many applications in gas separation, immobilized enzymes, and sensors due to their high porosity and high specific surface area. In most cases, MOF...

Claims

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Application Information

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IPC IPC(8): C08G83/00A61K47/69A61K47/59A61K45/00
CPCC08G83/008A61K47/6951A61K47/593A61K45/00A61K31/05A61K31/11A61K31/343A61K31/352
Inventor 袁超刘雅琦崔波赵萌卢璐柴晴晴
Owner QILU UNIV OF TECH
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