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Method for extracting baicalin from dilute brine under positive pressure and negative pressure

A technology of dilute salt water and positive and negative pressure, applied in the field of dilute salt water positive and negative pressure extraction of baicalin, can solve the problems of low extraction rate of baicalin, low utilization rate of raw materials, long extraction time, etc., and achieves protection from being hydrolyzed, The effect of reducing extraction time and improving extraction efficiency

Pending Publication Date: 2022-06-17
杭州佳嘉乐生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the technical problem to be solved in the present invention is to overcome the defects that the baicalein extraction method in the prior art has many extraction times, low extraction efficiency, low raw material utilization rate, and low baicalein extraction rate, thereby providing a dilute brine normal The method of extracting baicalin under negative pressure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The present embodiment provides a method for extracting baicalin with dilute salt water by positive and negative pressure, comprising the following steps:

[0056] 1. Weigh 250 g of baicalin raw material, and dry it at 70°C for 8 hours to kill enzymes and preserve glycosides. After crushing with a crusher, pass through a 20-mesh sieve, add 2000ml of deionized water and 2.5g of ammonium sulfate to soak.

[0057] 2. Pour it into a pressure vessel for positive and negative pressure extraction, charge the booster pump to 3MPa, keep the pressure for 0.5h, release the pressure quickly, use a vacuum pump to pump down to -3MPa, keep the pressure for 0.5h, return to normal pressure, filter (The screen mesh is 20 meshes) to obtain the filtrate, and the filter residue is used for later use.

[0058] 3. Pour the filter residue into the extraction equipment, add 2000ml of deionized water and 2.5g of ammonium sulfate, extract at 40°C for 1.5h, and filter (20 mesh mesh) to obtain a f...

Embodiment 2

[0064] The present embodiment provides a method for extracting baicalin with dilute salt water by positive and negative pressure, comprising the following steps:

[0065] 1. Weigh 250 g of baicalin raw material, and dry it at 70°C for 8 hours to kill enzymes and preserve glycosides. After crushing with a crusher, pass through a 20-mesh sieve, add 2000ml of deionized water and 2.5g of sodium sulfate to soak.

[0066] 2. Pour it into a pressure vessel for positive and negative pressure extraction, pressurize the booster pump to 3MPa, keep the pressure for 0.5h, release the pressure quickly, use a vacuum pump to pump down to -3MPa, keep the pressure for 0.5h, return to normal pressure, filter (The screen mesh is 20 meshes) to obtain the filtrate, and the filter residue is used for later use.

[0067] 3. Pour the filter residue into the extraction equipment, add 2000ml of deionized water and 2.5g of sodium sulfate, extract at 40°C for 1.5h, and filter (20 mesh mesh) to obtain the...

Embodiment 3

[0073] The present embodiment provides a method for extracting baicalin with dilute salt water by positive and negative pressure, comprising the following steps:

[0074] 1. Weigh 250 g of baicalin raw material, and dry it at 70°C for 8 hours to kill enzymes and preserve glycosides. After crushing with a crusher, pass through a 20-mesh sieve, add 2000ml of deionized water and 2.5g of sodium chloride to soak.

[0075] 2. Pour it into a pressure vessel for positive and negative pressure extraction, pressurize the booster pump to 3MPa, keep the pressure for 0.5h, release the pressure quickly, use a vacuum pump to pump down to -3MPa, keep the pressure for 0.5h, return to normal pressure, filter (The screen mesh is 20 meshes) to obtain the filtrate, and the filter residue is used for later use.

[0076] 3. Pour the filter residue into the extraction equipment, add 2000ml of deionized water and 2.5g of sodium chloride, extract at 40°C for 1.5h, and filter (20 mesh mesh) to obtain a...

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PUM

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Abstract

The invention belongs to the technical field of baicalin extraction, and particularly relates to a method for extracting baicalin from dilute brine under positive and negative pressures. The invention provides a method for extracting baicalin from dilute brine under positive and negative pressure, which adopts a positive and negative pressure extraction method, due to rapid change of pressure within a short time, the tissue structure of scutellaria baicalensis is changed and broken, the contact area with a solvent is increased, the mass transfer resistance is reduced, the baicalin is rapidly and fully dissolved, the yield of the baicalin is improved, the extraction time is shortened, and the extraction cost is reduced. The extraction efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of baicalin extraction, and in particular relates to a method for extracting baicalin with dilute salt water by positive and negative pressure. Background technique [0002] Scutellaria baicalensis is the dry root of the Lamiaceae plant, which is cold in nature and bitter in taste. Its component baicalin has pharmacological effects such as antibacterial and anti-inflammatory, heat-clearing and detoxifying, chelating metal ions, sedative, blood pressure, nerve protection, anti-allergic and clearing ultrasonic anions. The main quality control index components of the preparation. At present, the commercially available baicalin products have different specifications such as 30%, 50%, 70%, 75%, 80%, 85%, 95% and 98%, which can be used in different fields such as veterinary drugs, cosmetics, health dietary raw materials and medicines. . In the field of medicine, according to the content of baicalin, the medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
CPCC07H17/07C07H1/08
Inventor 陆跃乐孔叶凯王奇超袁超男
Owner 杭州佳嘉乐生物技术有限公司
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