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Application of triclosan in preparation of medicine for killing parasitic nematodes

A technology for triclosan and nematodes, applied in drug combinations, pharmaceutical formulas, anti-infective drugs, etc., to achieve high safety, significant killing effect, and low dosage

Active Publication Date: 2022-06-07
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, studies have found that a variety of plant extracts have different degrees of killing effects on nematodes. Resveratrol has an anthelmintic effect on newborn larvae and adults of Trichinella spiralis, but has no obvious lethal effect on muscle larvae in vitro

Method used

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  • Application of triclosan in preparation of medicine for killing parasitic nematodes
  • Application of triclosan in preparation of medicine for killing parasitic nematodes
  • Application of triclosan in preparation of medicine for killing parasitic nematodes

Examples

Experimental program
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Effect test

Embodiment 1

[0025] 1 Materials and methods

[0026] 1.1 Experimental animals, Trichinella species, materials

[0027] 1.1.1 Experimental animals: Rats and Kunming rats were purchased from the Laboratory Animal Center of Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences.

[0028] 1.1.2 Trichinella species: The Trichinella species used in this study was Trichinella spiralis Henan strain (Trichinellaspiralis, T1), which was passaged and preserved in Kunming mice.

[0029] 1.1.3 Reagents: The 10 active compounds used in the experiment are: octyl gallate (Mr282.33); 4-aminobutyric acid ethyl ester hydrochloride (Mr153.61); pyrrole-2-carboxylic acid (Mr111 .1); Indole-3-acetamide (Mr174.2); Estradiol benzoate (Mr376.49): 97.74% purity; Triclosan (Mr289.54): ﹥97%; o-Hydroxybenzene Acetic acid (Mr152.15); 1,5-pentanediamine (Mr175.1); spermidine hydrochloride (Mr254.63); cinnamyl alcohol (Mr134.18). All active compounds were purchased from Selleck Biotechnology Co...

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Abstract

The invention provides application of triclosan in preparation of a medicine for killing parasitic nematodes, and belongs to the technical field of medicinal chemistry. Triclosan has an obvious lethal effect on trichina in all stages, is low in dosage and high in safety, can be used as one of candidate molecules for treating nematode diseases, and can be used for treating nematode diseases. The important reference value is realized on the development of new nematode killing medicines.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to the application of triclosan in the preparation of a medicine for killing parasitic nematodes. Background technique [0002] Nematodes belong to the nematode class Nematoda of the phylum Nematoda. Most of the nematodes that parasitize the human body are intestinal parasites, such as hookworms, roundworms, whipworms, pinworms, etc., and some are intestinal and tissue parasites, such as Trichinella, adult parasites In the gut, the larvae live in the muscles. Different nematodes parasitize the human body with different symptoms. For example, trichinosis is a zoonotic parasitic disease and a widespread food-borne parasitic disease that can infect more than 150 mammals, including humans. , the main symptoms are systemic fever, abdominal pain, eyelid edema, myocarditis, systemic muscle pain, etc. Severely ill patients may even die due to complications, which will cause gre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/085A61P33/00
CPCA61K31/085A61P33/00Y02A50/30
Inventor 张念章徐媛滨付宝权李文卉王萌李婷婷曲自刚王金磊
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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