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Design synthesis of in-situ gel and application of in-situ gel in medicine for removing stones and fragments

An in-situ gel and calculus technology, applied in the field of urological medical materials, can solve the problems of residual body risk, poor calculus coating effect, complicated material preparation, etc., so as to affect postoperative healing, reduce calculus recurrence rate, biological good compatibility

Active Publication Date: 2022-05-24
THE FIFTH AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to increase the clearance rate of stones, some experts proposed the idea of ​​injecting curable fluids, such as the patient's own blood and adhesive polysaccharide solution, to form a bond with the stones and remove them together during the operation, but the intraoperative field of view is not clear. Clear, long curing time, complex material preparation and residual risk in the body, etc., make this kind of technology poor promotion
At present, existing patents (such as CN 105491966 A) use iron ions, calcium ions and polysaccharide acidic solutions combined with alginate polysaccharide solutions to coat stones, but there may still be poor stone coating effects and damage to tissues due to excessive acidity of the system. Disadvantages, affecting further promotion and use

Method used

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  • Design synthesis of in-situ gel and application of in-situ gel in medicine for removing stones and fragments
  • Design synthesis of in-situ gel and application of in-situ gel in medicine for removing stones and fragments
  • Design synthesis of in-situ gel and application of in-situ gel in medicine for removing stones and fragments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Removal of calculus and fragments thereof from containing calculi to be removed and fragments thereof of the present invention comprises the following steps:

[0062] (1) adding sodium alginate and methylene blue to deionized water, mixing and stirring to prepare dispersion system A with sodium alginate concentration of 2.0% and methylene blue concentration of 0.001%, wherein the pH value of dispersion system A is about 7.0; Calcium chloride is dissolved in deionized water to prepare dispersion system B with a calcium chloride concentration of 0.8%, wherein the pH value of dispersion system B is about 6.4;

[0063] (2) The simulated kidney was continuously injected with normal saline at a flow rate of 2.0 mL / min;

[0064] (3) 0.1 mL of dispersion system A was injected into the simulated kidney area containing the kidney stone fragments to be removed through the No. 5 tube;

[0065] (4) introducing the stone basket into the stone area that has been wrapped by the disper...

Embodiment 2

[0070] Removal of calculus and fragments thereof from containing calculi to be removed and fragments thereof of the present invention comprises the following steps:

[0071] (1) adding sodium alginate and methylene blue to deionized water, mixing and stirring to prepare dispersion system A with sodium alginate concentration of 1.0% and methylene blue concentration of 0.001%, wherein the pH value of dispersion system A is about 7.0; Calcium chloride is dissolved in deionized water to prepare dispersion system B with a calcium chloride concentration of 0.8%, wherein the pH value of dispersion system B is about 6.4;

[0072] (2) The simulated kidney was continuously injected with normal saline at a flow rate of 2.0 mL / min;

[0073] (3) 0.1 mL of dispersion system A was injected into the simulated kidney area containing the kidney stone fragments to be removed through the No. 5 tube;

[0074] (4) introducing the stone basket into the stone area that has been wrapped by the disper...

Embodiment 3

[0078] Removal of calculus and fragments thereof from containing calculi to be removed and fragments thereof of the present invention comprises the following steps:

[0079] (1) adding sodium alginate and methylene blue to deionized water, mixing and stirring to prepare dispersion system A with sodium alginate concentration of 1.5% and methylene blue concentration of 0.001%, wherein the pH value of dispersion system A is about 7.0; Calcium chloride is dissolved in deionized water to prepare dispersion system B with a calcium chloride concentration of 0.8%, wherein the pH value of dispersion system B is about 6.4;

[0080] (2) The simulated kidney was continuously injected with normal saline at a flow rate of 2.0 mL / min;

[0081] (3) 0.1 mL of dispersion system A was injected into the simulated kidney area containing the kidney stone fragments to be removed through the No. 5 tube;

[0082] (4) introducing the stone basket into the stone area that has been wrapped by the disper...

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Abstract

The invention discloses design and synthesis of in-situ gel and application of the in-situ gel in medicines for removing stones and fragments, and belongs to the technical field of medical material methods. According to the in-situ gel provided by the technical scheme of the invention, the in-situ gel can be formed in an ultrafast manner in a neutral environment in vivo, and stones and fragments thereof can be specifically and tightly wrapped; the technical scheme is applied to removal of calculi and fragments thereof, has the advantages of good biocompatibility, degradability, strong operability, specific coating of calculi and fragments thereof and the like, can effectively improve the operation efficiency and the removal rate of calculi and fragments thereof, reduces the number of operations, reduces the recurrence rate of calculi, and has a good application prospect. And the method has application prospects in urinary system intracavity operations such as flexible ureteroscope and the like.

Description

technical field [0001] The invention belongs to the field of urological medical materials and methods, in particular to the design and synthesis of an in-situ gel and its application in medicines for removing stones and fragments. Background technique [0002] At present, retrograde intra-renal surgery (RIRS) based on flexible-URS is a safer and less invasive method for the treatment of renal stones. RIRS uses laser lithotripsy to break large stones into extractable fragments, and then uses a stone basket to remove the broken stones of a certain size from the kidney through the ureteral access sheath (UAS). Despite the long-term optimization of laser systems, equipment, and surgical methods, laser lithotripsy inevitably results in the generation of a large number of tiny stone fragments that cannot be clamped and remain in the urinary system. Residual stone fragments can cause renal colic or even the formation of ureteral stone streets during the process of stone removal, c...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/04A61L31/14
CPCA61L31/042A61L31/145A61L31/028A61L2400/06A61L2300/442
Inventor 赖德辉吴丁财何汶懿江先汉卞军郭耀川黄榕康吴淑仪靳林何永忠
Owner THE FIFTH AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV
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