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Nerve-induced repair catheter stent as well as preparation method and application thereof

A catheter stent, nerve technology, applied in the direction of prosthesis, tissue regeneration, additive processing, etc., can solve the problems of damage to the donor site, source limitation, poor mechanical strength, etc., to increase the electrical conductivity and induce nerve repair. Effect

Active Publication Date: 2022-05-13
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]At present, autograft and artificial stent catheter are used to repair the catheter; autograft will cause damage to the donor site, and the source is limited; All have poor mechanical strength, basically no effect of promoting nerve repair, but simply provide an environment for nerve repair

Method used

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  • Nerve-induced repair catheter stent as well as preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0027] A preparation method for nerve induction repair catheter stent, comprising the steps of:

[0028] (1) First, add 1.6g of polylactic acid into 10mL of dichloromethane, ultrasonically disperse and dissolve to obtain a solution, then add 0.2mL of an aqueous dispersion of reduced graphene oxide with a concentration of 0.1g / mL to the solution, and stir evenly Finally, a 3D printer is used to prepare an outer tube support, which is a circular tube structure with an inner diameter of 2mm, an outer diameter of 2.5mm, and a length of 10mm;

[0029] (2) Take 10 mL of the decellularized extracellular matrix solution with a concentration of 1.5 wt%, and then add 0.16 g of methacrylic anhydride gelatin (GelMA) to disperse it in the decellularized extracellular matrix solution, and control the temperature to 4° C. Add 6uL of mouse nerve growth factor, add 0.48mg of photocuring agent HMPP 1173 in a light-proof environment, and use a 3D printer to prepare a cylindrical inner-filled sca...

Embodiment 2

[0032] A preparation method for nerve induction repair catheter stent, comprising the steps of:

[0033] (1) First, add 1.8g of polylactic acid into 10mL of dichloromethane, ultrasonically disperse and dissolve to obtain a solution, then add 0.2mL of an aqueous dispersion of reduced graphene oxide with a concentration of 0.1g / mL to the solution, and stir evenly Finally, a 3D printer is used to prepare an outer tube support, which is a circular tube structure with an inner diameter of 2.1 mm, an outer diameter of 2.5 mm, and a length of 20 mm;

[0034] (2) Take 10 mL of the decellularized extracellular matrix solution with a concentration of 1.5 wt%, and then add 0.20 g of methacrylic anhydride gelatin (GelMA) to disperse it in the decellularized extracellular matrix solution, and control the temperature to 4° C. Add 10 uL of mouse nerve growth factor, add 0.60 mg of photocuring agent HMPP 1173 in a light-proof environment, and use a 3D printer to prepare a cylindrical inner-fi...

Embodiment 3

[0037] A preparation method for nerve induction repair catheter stent, comprising the steps of:

[0038] (1) First, add 2.0g of polylactic acid into 10mL of dichloromethane, ultrasonically disperse and dissolve to obtain a solution, then add 0.2mL of an aqueous dispersion of reduced graphene oxide with a concentration of 0.1g / mL to the solution, and stir evenly Finally, a 3D printer is used to prepare an outer tube support, which is a circular tube structure with an inner diameter of 2.1 mm, an outer diameter of 2.5 mm, and a length of 20 mm;

[0039] (2) Take 10 mL of the decellularized extracellular matrix solution with a concentration of 1.5 wt%, then add 0.16 g of methacrylic anhydride gelatin (GelMA) to lyophilize the solid and disperse it in the decellularized extracellular matrix solution, and control the temperature at Add 10uL of mouse nerve growth factor at 4°C, add 0.48mg of photocuring agent IRGACURE 2959 in a light-proof environment, and use a 3D printer to prepar...

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Abstract

The invention relates to the technical field of biomedical materials, in particular to a nerve-induced repair catheter stent and a preparation method and application thereof. The nerve-induced repair catheter stent is divided into an outer catheter stent and an inner filler, the inner filler is a gelatin modified high-molecular polymer and extracellular matrix composite material, and the stent with an oriented fiber arrangement structure is prepared through 3D printing photocuring. The outer tube stent is formed by compounding a high-molecular polymer material with reduced graphene oxide nanoparticles and is formed by using a 3D printer. An outer tube stent material has a good mechanical supporting structure and electrical stimulation responsiveness (reduced graphene oxide and rGO have good mechanical strength for improving polymers, and nanoparticles have electrical stimulation responsiveness), and an internal filling stent has a good fiber directional arrangement structure, so that the electrical stimulation responsiveness of the outer tube stent material is improved, and the electrical stimulation responsiveness of the outer tube stent material is improved. The obvious promoting effect is achieved on inducing axial growth of nerves.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a nerve induction repair catheter bracket and a preparation method and application thereof. Background technique [0002] Structural or functional damage to peripheral nerves is mainly due to accidents, trauma, and other related reasons, and damage can lead to partial or complete loss of sensory, motor, and autonomic nerve functions, as well as neuropathic pain. Although there is a clear theoretical basis for the pathophysiology and regeneration mechanism of peripheral nerve injury (PNI), there is still a lack of reliable treatment methods that can ensure complete recovery of nerve function. Among them, the most common way to repair nerve injury is autologous transplantation. It has no immunity, high biological activity, suitable mechanical properties, etc. However, there are many limitations affecting its application, such as the donor site is prone to d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/36A61L27/44A61L27/50A61L27/54B33Y30/00B33Y70/10B33Y80/00
CPCA61L27/443A61L27/3633A61L27/227A61L27/222A61L27/54A61L27/50B33Y30/00B33Y70/10B33Y80/00A61L2430/32A61L2300/414
Inventor 翁雨雄樊李红陈江海刘爽郭远东魏浩杰
Owner WUHAN UNIV OF TECH
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