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Compound traditional Chinese medicine composition for treating chronic atrophic gastritis and application

A technology of atrophic gastritis and compound traditional Chinese medicine, applied in the field of pharmaceutical research and development, can solve problems such as inability to cure radically and drug side effects, and achieve the effects of improving the body's immunity, preventing precancerous lesions, and promoting the secretion of gastric juice

Active Publication Date: 2022-05-13
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it cannot be cured, and related drugs have certain side effects; on the contrary, in recent years, there have been more and more clinical reports on the treatment of CAG with traditional Chinese medicine, and the curative effect has been affirmed by the society. Traditional Chinese medicine mainly treats CAG through the following methods: Syndrome differentiation and treatment, Chinese patent medicine, acupuncture treatment and integration of traditional Chinese and Western medicine, etc., and many doctors have created personal experience prescriptions after years of clinical practice research, which have a significant effect on the reversal of CAG pathological types

Method used

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  • Compound traditional Chinese medicine composition for treating chronic atrophic gastritis and application
  • Compound traditional Chinese medicine composition for treating chronic atrophic gastritis and application
  • Compound traditional Chinese medicine composition for treating chronic atrophic gastritis and application

Examples

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Effect test

Embodiment 1

[0043] Example 1: Curative Effect Observation of Compound Chinese Medicine Composition in Treating Qi Deficiency and Blood Stasis Type Chronic Atrophic Gastritis

[0044] 1. Research object:

[0045] 1.1 Case source:

[0046]All case data come from January 2017-December 2021, patients with chronic atrophic gastritis of Qi deficiency and blood stasis who met the inclusion and exclusion criteria in the Digestive Endoscopy Clinic of Jiangsu Provincial Hospital of Traditional Chinese Medicine. This retrospective study took January 2019 as the boundary. Before January 2019, it was the old prescription of Meiqing Decoction, and after January 2019, it was the improved prescription of Meiqing Decoction (that is, the formula of the compound Chinese medicine composition of the present invention). A total of 148 patients were included, including 71 males, aged 26-77 years, (51±12.73) years old; 77 females, aged 31-78 years old, aged (43.5±12.02) years old.

[0047] 1.2 Diagnostic crite...

Embodiment 2

[0116] Embodiment 2: The compound Chinese medicine composition of the present invention treats the animal experiment of rat chronic atrophic gastritis 1, material and method

[0117] (1) Experimental animals and grouping: 48 male SD rats of SPF grade 8 weeks old (Speyford (Beijing) Biotechnology Co., Ltd., license number: SCXK (Beijing) 2016-0002), weighing 210-250g, divided into There are 6 groups of 8 animals in each group. The groups are: A. Blank control group, B. Pathological model group, C. High-dose Meiqing Decoction old prescription group, D. Low-dose Meiqing Decoction improved prescription group, E. Medium-dose Meiqing Decoction improved prescription group, F. High-dose Meiqing decoction modified prescription group. Animals were fed in the Animal Experiment Center of Jiangsu Provincial Hospital of Traditional Chinese Medicine (Affiliated Hospital of Nanjing University of Traditional Chinese Medicine), with a laboratory temperature of 18-22° C. and a relative humidity...

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Abstract

The invention relates to a compound traditional Chinese medicine composition for treating chronic atrophic gastritis. The compound traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 15 parts of fructus mume, 10 to 15 parts of radix cynanchi paniculati, 10 to 15 parts of radix pseudostellariae, 6 to 10 parts of rhizoma wenyujin concisum, 6 to 10 parts of fructus citri sarcodactylis, 8 to 10 parts of rhizoma curcumae, 10 to 15 parts of herba hedyotidis diffusae, 15 to 30 parts of herba salviae chinensis, 20 to 30 parts of fried semen coicis and 6 to 10 parts of fried hedgehog hide. The invention also discloses application of the compound traditional Chinese medicine composition for treating chronic atrophic gastritis in preparation of medicines, health-care products or foods for treating chronic atrophic gastritis. The compound traditional Chinese medicine composition disclosed by the invention has the effects of resisting tumors, preventing precancerous lesions and reducing the CAG cancerization rate; haemodynamics and haemorheology can be improved, and low nutritional states such as mucous membrane ischemia and hypoxia can be improved; secretion of gastric juice is promoted, and appetite is increased; the organism immunity is improved; fatigue and oxidation are resisted; the antibacterial effect on various pathogenic bacteria is achieved.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine composition for treating chronic atrophic gastritis and its application, and belongs to the technical field of medical research and development. Background technique [0002] Chronic atrophic gastritis (CAG) is a special type of chronic gastric mucosal inflammatory disease, the mucosa becomes thinner, folds flatten or even disappear, the number of glands decreases, and local tissues can regenerate, forming granular hyperplasia or polyps For a long time, the intestinal epithelial cells replace the original gastric mucosal epithelial cells in serious condition, and there is a certain risk of canceration. Most of them are elderly patients, but in recent years, due to changes in eating habits, increased life pressure and the influence of congenital factors, young patients are increasing day by day. Therefore, before CAG becomes cancerous, how to carry out effective patient management and int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K36/9068A61P1/04A61P35/00A61P7/00A61P37/04A61P1/14A61P39/00A61P39/06A61P31/04A61P31/10A61K35/36A61K35/64A61K35/24A61K35/618
CPCA61K36/736A61K36/27A61K36/36A61K36/9066A61K36/752A61K36/748A61K36/537A61K36/8994A61K35/36A61K36/346A61K36/185A61K36/8968A61K36/342A61K36/8984A61K36/233A61K36/71A61K36/66A61K35/64A61K36/235A61K36/714A61K36/9068A61K36/754A61K36/486A61K36/88A61K35/24A61K36/73A61K35/618A61K36/8966A61P1/04A61P35/00A61P7/00A61P37/04A61P1/14A61P39/00A61P39/06A61P31/04A61P31/10A61K2300/00Y02A50/30
Inventor 商洪涛刘溦溦商竞宇邓银香韩秀珍司阳
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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