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Ganglioside GD2 mobile detection device based on plasma modified electrode

A mobile detection device and ganglioside technology, applied in the field of sensors, can solve the problems of impossibility, dependence on counting, and inability to follow-up analysis of fluorescent markers, etc., to achieve fast response, amplify current signals, and reduce biological fixation steps Effect

Pending Publication Date: 2022-05-06
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Immunocytological staining and counting method, the chromogenic agent has autofluorescence, and the subsequent analysis of fluorescent markers cannot be performed during the substrate reaction driven by alkaline phosphatase. The counting needs to rely on the operator's personal experience and cannot be completely objective [7]

Method used

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  • Ganglioside GD2 mobile detection device based on plasma modified electrode
  • Ganglioside GD2 mobile detection device based on plasma modified electrode
  • Ganglioside GD2 mobile detection device based on plasma modified electrode

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Embodiment Construction

[0040] In order to make the purpose, technical solution and advantages of the present invention clearer, the implementation manners of the present invention will be further described in detail below.

[0041] The embodiment of the present invention uses nano-graphene hybrid gold plasma to modify the electrode, wherein the base material indium tin oxide (ITO) has extremely high light transmittance and electrical conductivity, and nano-graphene hybrid gold plasma has good photocatalytic enhancement The electrochemical signal effect can greatly improve the detection accuracy and sensitivity. In addition, the plasma immobilizes the GD2 antibody on the sensor as a sensitive layer through electrostatic adsorption, and uses the specific binding of the antigen and antibody to specifically recognize the bone marrow GD2 positive cells. And by constructing a mobile differential pulse electrochemical analysis system and relying on small programs to read the detection data in real time, th...

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Abstract

The invention discloses a ganglioside GD2 mobile detection device based on a plasma modified electrode, which comprises a ganglioside GD2 sensing electrode, a differential pulse electrochemical chip and a silk-screen printing electrochemical three-electrode sensing device, finishing nano graphene hybrid gold plasma modification on the ITO working electrode by a chronoamperometry; the ganglioside GD2 antibody is adsorbed by plasma static electricity; and high-sensitivity specific detection of the GD2 positive cells is realized through the differential pulse electrochemical analysis device. According to the invention, accurate detection of GD2 positive cells at the present stage is realized, and requirements in practical application are met.

Description

technical field [0001] The invention relates to the field of sensors, in particular to a ganglioside (GD2) movement detection device based on a plasma-modified electrode, which moves and displays the sensing analysis results in a WeChat applet in a mobile phone in real time. Background technique [0002] Neuroblastoma (NB), originating from the adrenal medulla or paravertebral sympathetic nervous system, is the most common extracranial solid tumor in children with a broad clinical course, characterized by spontaneous differentiation, rapid progression, and fatality [1,2] . Current methods for the detection of neuroblastoma microlesions mainly include immunocytology, flow cytometry, and quantitative reverse transcription polymerase chain reaction. [3] . In 2009, the International Neuroblastoma Risk Stratification Group (INRG) defined the use of immunocytology and quantitative reverse transcription polymerase chain reaction as an internationally accepted method for the detec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N27/48
CPCG01N27/3275G01N27/3277G01N27/3278G01N27/308G01N27/48
Inventor 李爽陈冲胡畅白永昌何峰明东
Owner TIANJIN UNIV
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