Arginine/lysine polypeptide microcapsule inclusion as well as preparation method and application thereof

Abstract

The invention discloses an arginine / lysine polypeptide microcapsule inclusion as well as a preparation method and application thereof. The microcapsule inclusion is prepared from the following raw materials: compound arginine / lysine polypeptide, glycerol, a polyglyceryl nonionic surfactant, glucan and the balance of water, wherein the compound arginine / lysine polypeptide comprises red scorpion toxin and conotoxin peptide. According to the microcapsule inclusion, a polyglyceryl nonionic surfactant is adopted as a carrier material, so that the compound polypeptide can be spontaneously wrapped in a microcapsule bilayer, a high-stability microcapsule inclusion structure is formed, and the compound polypeptide can achieve the effects of resisting aging, wrinkles and oxidation. The preparation method of the microcapsule inclusion avoids the addition of excipients and plasticizers required by traditional liposome preparation, and is simple. The microcapsule inclusion can be conveniently and stably dispersed in different types of cosmetic substrates such as skin care emulsion, cream, face cleansing, essence, toning lotion and the like to be prepared into cosmetics or skin care products for application.

Description

technical field [0001] The invention relates to the technical field of microcapsule inclusions, in particular to an arginine / lysine polypeptide microcapsule inclusion and its preparation method and application. Background technique [0002] Microcapsule technology refers to the technology of using natural or synthetic polymer materials to wrap dispersed solid particles, liquid or gas substances to form a semi-permeable or sealed microparticle technology. The process of encapsulation is called microencapsulation, and the tiny particles formed are called microcapsules. Microcapsules have two basic components, the substance enclosed in the microcapsule is called the core material, and the outer "shell" is called the wall material. During the preparation of microcapsules, the wall material can isolate the core material from the external environment, and then release the core material under appropriate conditions. [0003] Traditional techniques for preparing microcapsules incl...

AI Technical Summary

Problems solved by technology

However, the preparation of microcapsules by spray drying has certain requirements on temperature, which will cause structural changes in some heat-sensitive drugs, so this will restrict the application range of spray drying.

Although the preparation of microcapsules by the supercritical fluid method is environmentally friendly and can avoid the use of organic solvents, the equipment is expensive, and the parameter control and structural modification technology is not yet mature, so it is difficult to achieve industrialized mass production

Although the preparation of microcapsules by solvent diffusion method is simple and easy to empty, there is a problem of organic solvent residue

Images