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Implanted instrument nano coating as well as preparation method and application thereof

A nano-coating and device technology, applied in the fields of polyphenol surface functionalized nanoparticles, implanted device nano-coating and its preparation, can solve problems such as premature water reaction, achieve broad application value, and promote osteogenic differentiation , The effect of good sterilization ability in the body

Active Publication Date: 2022-04-19
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calcium peroxide (CaO2) can generate reactive oxygen species (ROS) and calcium ions when it meets water, which can be used as a non-antibiotic prophylaxis and is an ideal material for antibacterial and osteogenic The problem of premature water reaction, which is the main obstacle to its early prevention of periprosthetic infection

Method used

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  • Implanted instrument nano coating as well as preparation method and application thereof
  • Implanted instrument nano coating as well as preparation method and application thereof
  • Implanted instrument nano coating as well as preparation method and application thereof

Examples

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preparation example Construction

[0038] In a fourth aspect of the present disclosure, a method for preparing a nano-coating for an implanted device is provided, comprising: soaking the implanted device in CaO 2 -TA nanoparticle solution, followed by adding metal ion solution for reaction.

[0039] Preferably, the solution is absolute ethanol, metal ions are added after stirring, and the reaction time is 10-14 hours; the stirring time is 8-16 hours, preferably 12 hours;

[0040] Preferably, the metal ion solution is a copper ion solution, preferably CuCl 2 ; The concentration of the metal ion solution is 0.02mol / L-0.03mol / L, the CaO 2-The concentration of the TA nanoparticle solution is 0.03mol / L-0.04mol / L.

[0041] Preferably, the preparation method also includes the process of taking out the implanted device after the reaction is completed, washing and drying; further, the number of ethanol cleaning is 2 to 5 times, preferably 3 times;

[0042] Preferably, the implanted device needs to be purified before ...

Embodiment 1

[0046] Example 1: Synthesis of Polyphenol Surface Functionalized Nanoparticles

[0047] Dissolve 0.1g CaCl2 and 0.35g PVP in 15mL absolute ethanol by ultrasonication, add 1mL NH 4 OH (0.8M), and add 0.2mL H at a rate of 0.05mL / min with a syringe pump 2 o 2 (1M) solution, stirred for 10 minutes to obtain a light blue milky white solution. Subsequently, 10 μL of TA solution (24 mM) was added to the above dispersion system. The obtained polyphenol surface-functionalized nanoparticles were collected by centrifugation (10000 rpm×5 min), and washed 3 times with absolute ethanol. The prepared polyphenol surface-functionalized nanoparticles were stored at 4°C. The morphology of polyphenol surface-functionalized nanoparticles was examined by TEM, as figure 1 As shown, it can be seen that the prepared nanoparticles are regular in shape, spherical in shape, and the particle size is about 200nm.

Embodiment 2

[0048] Embodiment 2: the synthesis of nanocoating of implant device

[0049] Firstly, titanium sheets (Ti, Φ10×2mm) and titanium screws (Ti, Φ2×6mm) purchased from Jiangsu Bayers Company were passed through acetone (≥99.5%), ethylene glycol (≥99.5%), and ultrapure water in sequence. Wash for 15 minutes under the action of ultrasound. Then, the purified titanium sheet and titanium screw were treated with CaO at a concentration of 35 mM 2 -Soak TA nanoparticles in ethanol solution, and add Cu at a concentration of 24mM 2+ The metal polyphenol network MPN coating (MPN@Ti) was prepared by stirring for 12 hours, washed with ethanol three times, and dried in an oven for later use. The surface morphology and surface element distribution of MPN@Ti were obtained by SEM ( figure 2 ), the element change of MPN@Ti and Ti was analyzed by XPS ( image 3 ).

[0050] from figure 2 and image 3 It can be seen that the prepared MPN@Ti coating has a uniformly distributed morphology stru...

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Abstract

The invention relates to a polyphenol surface functionalized nanoparticle, an implanted instrument nano coating and a preparation method and application thereof.The nano coating is obtained by coordinating the polyphenol surface functionalized nanoparticle and metal ions, the nanoparticle is obtained by wrapping the surface of tannic acid with CaO2, and the nano coating can respond to the acidic environment derived by splitting decomposition in infection; the phenomenon that CaO2 reacts with water too early is avoided, the nano coating can sterilize in a non-antibiotic mode, and bone differentiation is promoted.

Description

technical field [0001] The invention relates to the technical field of orthopedic artificial prosthesis, in particular to a polyphenol surface-functionalized nanoparticle, a nano-coating for an implanted device, and a preparation method and application thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Periprosthetic infection is a serious complication after artificial joint replacement, which can lead to surgical failure, patient disability and even death. At the same time, the microenvironment created by bacteria (mainly caused by Staphylococcus aureus, especially methicillin-resistant Staphylococcus aureus) can also inhibit the osseointegration of the prosthetic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/30A61L27/50A61L27/54
CPCA61L27/28A61L27/306A61L27/50A61L27/54A61L2400/12A61L2420/02A61L2300/404A61L2420/04A61L2430/02A61L2420/06A61L2300/606A61L2300/11
Inventor 姜新义张盛昌柴啟浩张元凯唐春伟
Owner SHANDONG UNIV
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