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Chromatographic separation method for glycerol glucoside

A technology for separating glycerin from glucoside, which is applied in the field of chromatographic separation, and can solve problems such as difficulty in achieving the separation effect of glycerin

Active Publication Date: 2022-04-15
山东兆光色谱分离技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But under the condition that adopts existing adsorption resin and uses water as eluent, it is difficult to reach the described separation effect to glycerin

Method used

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  • Chromatographic separation method for glycerol glucoside
  • Chromatographic separation method for glycerol glucoside
  • Chromatographic separation method for glycerol glucoside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Through the following steps, the silicic acid modified calcium strontium type strongly acidic cation exchange resin of the present embodiment is prepared:

[0038] (1) 500ml of hydrogen-type strongly acidic cation exchange resin soaked in water (model 001x7, sieve the part with an outer diameter of microspheres of 0.2-0.4mm), put it in a 2000ml plastic cup, add 0.42mol / L calcium acetate aqueous solution at room temperature 1000ml for ion exchange, after continuous stirring for 2 hours, it is detected that the calcium concentration in the aqueous solution is lower than 0.002mol / L, drained, washed with 3000ml of water for 4 times, after washing, add water to a total volume of 650ml, pour into a glass bottle, cover and seal, and place at 75°C Place the homogenization treatment in the oven for 120 hours, turn it into hydrogen-calcium type strongly acidic cation exchange resin, and detect the calcium exchange degree of cations in the resin to be 83.1%; Acid group;

[0039] ...

Embodiment 2

[0044] Operate basically according to the steps (1)-(4) of Example 1 to prepare the calcium strontium type strong acidic cation exchange resin modified by silicic acid of this embodiment, the main difference is that the hydrogen type strong acidic cation exchange resin used in step (1) The resin model is 001x3, and the part of the microsphere outer diameter of 0.2-0.4mm is sieved, the concentration of calcium acetate aqueous solution is 0.35mol / L, and the calcium exchange degree of cations in the resin is detected to be 88.5%; step (2) prepares silicic acid-modified hydrogen Calcium type strongly acidic cation exchange resin contains about 0.35wt% of silicon dioxide in terms of dry resin and silicon dioxide; step (4) makes the calcium strontium type strongly acidic cation exchange resin modified by silicic acid, and detects the content of cations in the resin The exchange degree of strontium is 9.0%, and the exchange degree of calcium strontium is 100%.

Embodiment 3

[0056] Using 5 sets of chromatographic separation experimental devices with the same configuration, the separation experiments of glycerol and glucoside were carried out respectively. Each set of configuration chromatographic separation experimental device includes a self-made jacketed glass column and supporting control equipment; the inner diameter of the glass column is 22mm, and the height is 1500mm. Resin 400ml; Glycerol glucoside solution and mobile phase flow in and out, control the flow rate of the liquid, and the column temperature is controlled within 2°C of the required temperature by circulating hot water through the jacket, and the glycerol glucoside solution and mobile phase enter The temperature of the material is the same as the temperature of the column; the miniature photoelectric probe of the detector is inserted into the outlet pipe of the separation column to conduct continuous and real-time preliminary detection of the components of the outlet liquid. For...

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Abstract

The invention provides a method for chromatographic separation of glycerol glucoside, which adopts specially prepared adsorption separation resin, particularly a multi-separator simulated moving bed chromatographic separation device adopting the adsorption separation resin, and can be used for separating the glycerol glucoside under the condition that water is used as a mobile phase. The method has high separation efficiency on glycerol glucoside, glycerol and fructose / glucose, the yield of glycerol glucoside is greater than or equal to 85%, and the purity of the concentrated glycerol glucoside product is greater than or equal to 90% and even greater than or equal to 99%; and the method also has higher separation efficiency on glycerol, fructose and glucose.

Description

technical field [0001] The invention belongs to the technical field of chromatographic separation, and in particular relates to a method for chromatographic separation of glycerol glucoside. Background technique [0002] The three-dimensional configuration is 2-O-α-D-glycerol glucoside, referred to as 2-αGG, commonly known as glycerol glucoside, glycerol glucoside. Due to its important physiological functions, 2-O-α-D-glycerol glucoside has shown great potential in the fields of cosmetics and health care; studies have shown that its main application effects include skin moisturizing care, dental caries prevention, and inhibition of neutralization in fat cells. Fat accumulation, anti-allergic and anti-cancer. Usually, in the index requirement of glycerol glucoside products, the content of 2-O-α-D-glycerol glucoside is ≥90wt%. [0003] At present, the main method for preparing 2-O-α-D-glycerol glucoside is the enzyme-catalyzed synthesis method. This method mainly comprises ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/06C07H15/04
CPCY02P20/10
Inventor 王兆光
Owner 山东兆光色谱分离技术有限公司
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