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Lactobacillus plantarum and application thereof in prevention and/or treatment of central nervous system diseases

A technology of Lactobacillus plantarum and central nervous system, applied in the field of microorganisms, can solve problems such as limited, expensive, and large side effects

Pending Publication Date: 2022-04-12
杭州普元生物技术有限公司
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In the prior art, the drugs supported by evidence-based medical arguments are quite limited and expensive, with limited therapeutic effects and possible side effects. Moreover, the prior art does not clarify how to treat and prevent MS diseases through microbial flora, Therefore, the research and development of drugs that can safely and effectively prevent and treat multiple sclerosis to eliminate the abnormalities of neuroimmune inflammation in patients has important guiding significance for the clinical treatment of multiple sclerosis

Method used

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  • Lactobacillus plantarum and application thereof in prevention and/or treatment of central nervous system diseases
  • Lactobacillus plantarum and application thereof in prevention and/or treatment of central nervous system diseases
  • Lactobacillus plantarum and application thereof in prevention and/or treatment of central nervous system diseases

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Embodiment 1

[0039] Embodiment 1: Lactobacillus plantarum Pm005 bacteria can alleviate the phenotype of mouse EAE model

[0040] (1) Prepare WT mice

[0041]Purchased 20 8-week-old wild-type BL / C57 mice from Shanghai Lingchang Company and raised them in the SPF barrier system. After one week of adaptation, the mice were randomly divided into two groups, namely normal saline-EAE control group and Lactobacillus plantarum Pm005 bacteria-EAE group.

[0042] (2) Intestinal colonization of Lactobacillus plantarum Pm005

[0043] Inoculate Lactobacillus plantarum Pm005 in liquid MRS medium, anaerobically and statically culture at 37°C for 20-22h, then centrifuge at 8000rpm for 5min to collect the bacteria, wash twice with normal saline, and then resuspend the bacteria In normal saline, the final concentration is about 5×10 9 CFU / mL. The dose of 200 μL Lactobacillus plantarum Pm002 per mouse was administered to the WT mice, and the treatment was repeated every other day for 2 weeks. Meanwhile, ...

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Abstract

The invention discloses an application of lactobacillus plantarum in relieving and treating multiple sclerosis. The lactobacillus plantarum Pm005 is obtained through separation, the lactobacillus plantarum Pm005 is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number of the lactobacillus plantarum Pm005 is CCTCC NO: M 2021928. In-vivo and in-vitro related experiments prove that the lactobacillus plantarum Pm005 has excellent resistance to central nervous system inflammatory demyelination diseases (including multiple sclerosis, optic neuromyelitis and acute spread encephalomyelitis), has no toxic or side effect, and has an important application value.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a lactobacillus plantarum and its application in preventing and / or treating diseases of the central nervous system. Background technique [0002] Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelinating lesions in the white matter of the central nervous system. Inflammatory diseases associated with central nervous system (CNS) inflammation, characterized by disintegration and loss of myelin sheath, degeneration and proliferation of oligodendrocytes, and perivascular inflammatory cell infiltration Disorders, weakness, bladder and bowel disturbances, sexual dysfunction, pain, tremors, paroxysmal manifestations, visual disturbances, psychological problems, and cognitive impairment are the main clinical manifestations. There is as yet no effective cure for MS. [0003] Most of the drugs currently used to treat multiple sclerosis are hormon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/747A61P25/00A61P25/28C12R1/25
Inventor 梁启明许王赟
Owner 杭州普元生物技术有限公司
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