High-strength self-recoverable multifunctional conductive hydrogel with temperature/pH dual response as well as preparation method and application of high-strength self-recoverable multifunctional conductive hydrogel

A conductive hydrogel and dual-response technology, applied in the field of conductive hydrogel, can solve the problems that conductive hydrogel cannot meet the actual needs of the biomedical field, and achieve improved biocompatibility, pH responsiveness, and mechanical properties performance effect

Active Publication Date: 2022-04-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the advancement and deepening of research and application, single-functional conductive hydrogels can no longer meet the actual needs of many biomedical fields.

Method used

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  • High-strength self-recoverable multifunctional conductive hydrogel with temperature/pH dual response as well as preparation method and application of high-strength self-recoverable multifunctional conductive hydrogel
  • High-strength self-recoverable multifunctional conductive hydrogel with temperature/pH dual response as well as preparation method and application of high-strength self-recoverable multifunctional conductive hydrogel
  • High-strength self-recoverable multifunctional conductive hydrogel with temperature/pH dual response as well as preparation method and application of high-strength self-recoverable multifunctional conductive hydrogel

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Experimental program
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Effect test

Embodiment 1

[0031] 1) Configuration of pre-polymerization solution: Dissolve 23 parts of N-isopropylacrylamide, 2.5 parts of sodium acrylate, 0.6 part of sodium hyaluronate, 0.02 parts of MBA, and 2 parts of XLS in 100 parts of water according to mass, and magnetically stir After dissolving evenly, place it in a 4°C environment for later use;

[0032] 2) Preparation of hydrogel: Add 0.5 parts of APS and 1 part of TEMED to the above prepolymerization solution according to mass, vortex and shake for 60 seconds, pour the obtained solution into a gel forming mold, and place the mold at 4°C After standing in the environment for 20 hours, the gel can be demoulded and used.

Embodiment 2

[0034] 1) Configuration of prepolymerization solution: by mass, 30 parts of N-isopropylacrylamide, 2 parts of dimethyl-2-methacryloyloxyethyl-3-sulfopropylammonium (MEDSA), 0.5 1 part of sodium alginate, 0.03 part of MBA, 3 parts of XLS were dissolved in 100 parts of water, stirred evenly by magnetic force, and placed in an environment of 4°C for later use;

[0035] 2) Preparation of hydrogel: Add 1 part of APS and 1 part of TEMED to the above prepolymerization solution according to mass, vortex for 90 seconds, pour the obtained solution into a gel forming mold, and place the mold at 4°C After standing in the environment for 24 hours, the gel can be demoulded and used.

Embodiment 3

[0037] 1) Configuration of prepolymerization solution: Dissolve 25 parts of N-isopropylacrylamide, 2.8 parts of sodium crotonate, 1 part of sodium carboxymethylcellulose, 0.02 parts of MBA, and 4 parts of XLG in 100 parts by mass In the water, after the magnetic stirring is dissolved evenly, it is placed in a 4°C environment for later use;

[0038] 2) Preparation of hydrogel: Add 0.5 part of KPS and 1 part of sodium thiosulfate to the above-mentioned prepolymerization solution according to mass, vortex for 120 seconds, pour the obtained solution into a gel forming mold, and place the mold After standing at 4°C for 24 hours, the gel can be demolded and used.

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Abstract

The invention relates to high-strength self-restorable conductive hydrogel with temperature / pH dual response as well as a preparation method and application thereof. The hydrogel is prepared by dissolving a comonomer A, a comonomer B, a biomacromolecule C, a chemical cross-linking agent D and a physical cross-linking agent E in water and then polymerizing. The hydrogel prepared by the invention not only has temperature sensitive characteristics and pH sensitive characteristics, but also has relatively high strength and tensile rate, can be circularly stretched, and can be self-recovered and even self-enhanced. Besides, the hydrogel disclosed by the invention also has electrical conductivity, and the electrical conductivity of the hydrogel can be changed along with the change of the temperature, the stretching ratio and the environmental pH value, so that the electrical conductivity of the hydrogel has multiple sensitivities, and in addition, the hydrogel also has universal adhesion. Based on the attributes, the hydrogel is expected to be applied to a plurality of biomedical fields such as biosensors, wearable electronic skin, soft tissue engineering, drug controlled release and the like.

Description

technical field [0001] The invention relates to a conductive hydrogel, in particular to a high-strength, self-recoverable multifunctional conductive hydrogel with dual response to temperature / pH, and a preparation method and application thereof. Background technique [0002] In recent years, conductive hydrogels have received extensive exploration and attention due to their great application potential in many fields such as electronic skin, bioelectronic sensors, and tissue engineering. With the advancement and deepening of research and application, single-functional conductive hydrogels can no longer meet the actual needs of many biomedical fields. For example, the field of bionic electronic skin not only requires hydrogels to have good mechanical properties, but also requires conductive hydrogels to respond to changes in the external environment, and also requires conductive hydrogels to undergo volume changes and electrical signal changes under stimulation. Furthermore, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F251/02C08F220/54C08F220/06C08F222/38C08F220/38C08F220/04C08F220/36C08F283/02C08F230/02C08J3/075C08L51/02C08L51/08
Inventor 胡巧玲姜质琦董晓飞
Owner ZHEJIANG UNIV
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