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Pure traditional Chinese medicine gel for high-risk HPV (human papilloma virus) persistent infection

A technology of persistent infection and gel, which is applied in the directions of drug combination, pharmaceutical formula, and medical preparations containing active ingredients, etc., can solve the problems of poor treatment effect of high-risk HPV persistent infection, etc. The effect of improving the treatment effect

Inactive Publication Date: 2022-04-12
闫桂敏 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a new drug gel for high-risk HPV persistent infection, which has the advantages of pure Chinese medicine ingredients, safety and effectiveness, no toxic and side effects, stable properties, and convenient use, and can solve the problem of high-risk HPV in the lower reproductive tract of women. The problem of poor treatment of persistent infections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047] The present invention also provides a preparation method of the medicament. The method is as follows: prepare a water-based gel carrier, use it as a solvent after standing still, and then add Chinese medicinal ingredients of the same weight as the water-based gel carrier, which are mixed in proportion, as a solute, and mix Evenly, stir with a mixer to make a drug gel, and then fill it into a vaginal drug delivery pusher. Each pusher is filled with 5 grams of purified traditional Chinese medicine gel, and then sterilized by cobalt 60, then packaged and stored for use.

[0048] The equipment and other specific conditions used in this method are known to those skilled in the art.

[0049] The present invention also provides the use of the purified traditional Chinese medicine gel prepared by the method for high-risk HPV persistent infection, and the medicine gel is used for preparing vaginal administration medicaments.

[0050] The method of using this drug is as follows: ...

Embodiment 1

[0052] Example 1: Preparation of purified traditional Chinese medicine gel for high-risk HPV persistent infection.

[0053] Purchased 12 kinds of purified traditional Chinese medicine extract powders including Banlangen, Andrographis paniculata, Scutellaria barbata, Desmodium, Curcuma, Phellodendron Phellodendron, Sophora flavescens, Turmeric, dried ginger, catechu, alum, and borneol, which were respectively from famous pharmaceutical factories in the country. Purified traditional Chinese medicine produced by advanced technology. The water content of the 12 kinds of purified traditional Chinese medicines were all lower than 6%.

[0054] The proportion of 12 kinds of purified Chinese medicines in the traditional Chinese medicine ingredients is calculated by mass percentage: Radix Radix 15%, Andrographis 10%, Banzhilian 10%, Desmodium 10%, Curcuma 10%, Cortex Phellodendri 10%, Sophora flavescens 7%, Gold 7%, dried ginger 7%, catechin 6%, alum 5.5%, borneol 2.5%.

[0055] Mix t...

Embodiment 2

[0063] Example 2: Clinical application of purified traditional Chinese medicine gel for high-risk HPV persistent infection.

[0064] The medicinal gel prepared by the invention is used to treat the persistent infection of high-risk HPV in the female lower reproductive tract, and long-term clinical observations have been carried out, and the effect is obvious and meets expectations.

[0065] The specific data are as follows: After clinical medication observation of 168 female patients with persistent infection of high-risk HPV in the lower genital tract and 56 cases of low-grade cervical precancerous lesions, the HPV negative conversion rate was 89.7%, and the cure rate of low-grade precancerous lesions was 86.5%. The negative conversion rate and cure rate are significantly higher than other products currently used for the treatment of persistent high-risk HPV infection. No adverse reactions occurred during or after use.

[0066] A typical case is introduced as follows: Liu, 2...

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Abstract

The invention discloses pure traditional Chinese medicine gel for high-risk HPV (human papilloma virus) persistent infection. The pure traditional Chinese medicine gel comprises traditional Chinese medicine components and a water-based gel carrier, the traditional Chinese medicine components comprise radix isatidis, herba andrographitis, herba scutellariae barbatae, herba lysimachiae, rhizoma curcumae, cortex phellodendri, radix sophorae flavescentis, radix curcumae, rhizoma zingiberis, catechu, alumen and borneol. The weight ratio of the traditional Chinese medicine components to the hydrogel carrier is 1: 1. All the traditional Chinese medicine components adopt purified traditional Chinese medicine extract powder. The invention also provides application of the medicinal gel, and the medicinal gel is used for preparing a medicament for vaginal administration. The invention also provides a preparation method of the medicament. The gel adopts pure traditional Chinese medicine components, has the advantages of being safe, effective, stable in character, convenient to use and the like, solves the problem of insufficient dosage of traditional Chinese medicine in the vagina, and overcomes the problems of sanitation, impurities, pollution and the like of traditional Chinese medicine decoction pieces.

Description

technical field [0001] The invention relates to a medicine gel for human papillomavirus infection, in particular to a purified traditional Chinese medicine gel for high-risk HPV persistent infection. Background technique [0002] HPV (human papillomavirus, hereinafter referred to as "HPV") is a papillomavirus A genus belonging to the Papovaviridae family, and is a small DNA virus. So far, more than 150 subtypes of HPV have been found, 40 of which can infect the female reproductive tract. According to the size of its possibility of causing cervical cancer, HPV is divided into high-risk and low-risk types. [0003] HPV infection is a common female lower reproductive tract infection and belongs to sexually transmitted infection. The HPV infection rate of Chinese women is about 15%; about 70% of women have been infected with HPV in their lifetime; for women around 30 years old, the transient HPV infection rate is as high as 91%, and the high-risk HPV infection rate is as high ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/06A61P31/20A61P15/00A61K33/06A61K31/045
Inventor 闫桂敏刘曰儒姜伟杰李国亮
Owner 闫桂敏
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