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Fat component used in medical formula food for treating sarcopenia syndrome as well as preparation method and application of fat component

A technology for muscle attenuation and formula food, applied in the direction of edible oil/fat, application, food science, etc., can solve the problems of fat fatty acid ratio and function understanding, and achieve the goal of inhibiting relative expression, inhibiting inflammatory response, and improving fluidity Effect

Active Publication Date: 2022-04-12
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research and development of complete nutrition formula food for sarcopenia syndrome is in its infancy in China, and the understanding of fatty acid ratio and function of oil is relatively shallow. How to prepare a complete nutrition formula food for sarcopenia syndrome is an unresolved technology in this field question

Method used

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  • Fat component used in medical formula food for treating sarcopenia syndrome as well as preparation method and application of fat component
  • Fat component used in medical formula food for treating sarcopenia syndrome as well as preparation method and application of fat component
  • Fat component used in medical formula food for treating sarcopenia syndrome as well as preparation method and application of fat component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051]Fat components used in sarcopenia medical formula foods, including the following raw materials in weight percentages: 45% medium chain triglycerides, 12.5% ​​sesame oil, 12.5% ​​flaxseed oil, 12.5% ​​krill oil, 10% Fish Oil, 7.5% Peanut Oil.

[0052] At room temperature, various oils (except medium-chain triglycerides) are added into the reactor according to the mass ratio at room temperature, mixed and stirred, the stirring time is 15min, the stirring speed is 100rpm, and the mixed oil is obtained after stirring; the heating rate is 4°C / min, heat up to 35min, stirring speed is 100rpm, add medium-chain triglyceride after stirring, continue stirring for 20min, stop stirring, then cool down to room temperature at 4°C / min, and end stirring.

[0053] The fatty acid composition and lipid accompanying substances (sesaxanol, astaxanthin, tocopherol, etc.) content of the fat components were detected, and the results are shown in Table 1 and Table 2, respectively.

[0054] Muscl...

Embodiment 2

[0057] Fat components used in sarcopenia medical formula food, including the following raw materials in weight percentage: 45% medium chain triglycerides, 15% sesame oil, 10% flaxseed oil, 10% krill oil, 15% Fish oil, 5% peanut oil, each component is mixed and stirred with various oils and fats at room temperature to obtain a finished product; the specific preparation method is the same as in Example 1.

[0058] The fatty acid composition and lipid accompanying substances (sesaxanol, astaxanthin, tocopherol, etc.) content of the fat components were detected, and the results are shown in Table 1 and Table 2, respectively.

[0059] Muscle mass was assessed by the juvenile zebrafish model, as shown in figure 1 shown.

[0060] The expression of mTOR, AMPK, and NF-κB in muscle tissue, the fluidity of cell membrane, and the fatty acid composition of muscle cells were evaluated and analyzed through the aged zebrafish model. The results are as follows: figure 2 , image 3 , Figu...

Embodiment 3

[0062] Fat components used in sarcopenia medical formula foods, including the following raw materials in weight percentages: 60% medium chain triglycerides, 10% sesame oil, 10% flaxseed oil, 10% krill oil, 5% Fish oil, 5% peanut oil, each component is mixed and stirred with various oils and fats at room temperature to obtain a finished product; the specific preparation method is the same as in Example 1.

[0063] The fatty acid composition and lipid accompanying substances (sesaxanol, astaxanthin, tocopherol, etc.) content of the fat components were detected, and the results are shown in Table 1 and Table 2, respectively.

[0064] Muscle mass was assessed by the juvenile zebrafish model, as shown in figure 1 shown.

[0065] The expression of mTOR, AMPK, and NF-κB in muscle tissue, the fluidity of cell membrane, and the fatty acid composition of muscle cells were evaluated and analyzed through the aged zebrafish model. The results are as follows: figure 2 , image 3 , Fig...

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Abstract

The invention discloses a fat component used in medical formula food for treating sarcopenia syndrome as well as a preparation method and application of the fat component, and belongs to the field of formula food for special medical purposes. The fat component comprises the following components in percentage by mass: 30-60% of medium chain triglyceride; the total percentage is 100%; the nutritional grease is a grease mixture composed of two or more of sesame oil, linseed oil, krill oil, fish oil and peanut oil. In the fatty acid composition, the level of omega-3 polyunsaturated fatty acid is high, the omega-3 polyunsaturated fatty acid is matched with phospholipid type and glyceride type, omega-3 polyunsaturated fatty acid can be gradually utilized during digestion and absorption, the anti-inflammatory effect is achieved, meanwhile, an mTOR signal channel and an AMPK signal channel can be activated, synthesis of protein is promoted, and the protein activity is improved. The NF-kappa B relative expression quantity is inhibited, the inflammatory response is inhibited, the proportion and fluidity of polyunsaturated fatty acids of cell membranes are improved, and the sarcopenia syndrome is facilitated.

Description

technical field [0001] The invention relates to the field of formula food for special medical use, in particular to a fat component used in medical formula food for sarcopenia syndrome, a preparation method and application. Background technique [0002] Sarcopenia syndrome is a disorder characterized by reduced skeletal muscle mass and decreased skeletal muscle strength, with associated risks of disability and death, and significantly reduced quality of life for the patient. According to reports, skeletal muscle mass increases and decreases with age, and chronic muscle loss is about 30% over the age of 60, and 30% muscle loss will affect the normal function of muscles. In addition, long-term bed rest, sedentary, insufficient protein intake, gastrointestinal dysfunction, digestive and absorption disorders, and taking drugs can all lead to muscle attenuation. Sarcopenia can be divided into three categories according to the etiology: primary, secondary and nutrition-related. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23D9/007A23D9/00A23D9/04
Inventor 刘睿杰王章铁常明郭怡雯徐鑫王兴国
Owner JIANGNAN UNIV
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