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Application of baohuoside I in preparation of medicine for treating rheumatoid arthritis and osteoporosis and medicine

A technology for osteoporosis and baohuoside, which is applied in drug combinations, bone diseases, pharmaceutical formulations, etc., can solve the problems of few reports of osteoporosis-related drugs, and achieve the purpose of inhibiting osteoclast differentiation, improving bone resorption, and inhibiting osteoporosis. The effect of clinical treatment

Pending Publication Date: 2022-04-08
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Baohuoside I is a flavonoid compound obtained from Epimedium korean, which has the functions of inducing apoptosis and anti-tumor activity, but its application in the treatment of rheumatoid arthritis and osteoporosis-related drugs is rarely reported

Method used

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  • Application of baohuoside I in preparation of medicine for treating rheumatoid arthritis and osteoporosis and medicine
  • Application of baohuoside I in preparation of medicine for treating rheumatoid arthritis and osteoporosis and medicine
  • Application of baohuoside I in preparation of medicine for treating rheumatoid arthritis and osteoporosis and medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A liquid preparation for treating rheumatoid arthritis and osteoporosis, the specific steps of which are as follows:

[0036] Weigh the components of the liquid preparation according to the following formula: baojoside I 20mg, sorbitol 300mg, potassium sorbate 800mg, 20ml sterilized water. The preparation of the liquid preparation is carried out according to conventional techniques.

Embodiment 2

[0038] A tablet for treating rheumatoid arthritis and osteoporosis, the concrete steps are as follows:

[0039] The tablet components were weighed according to the following formula: 20 mg of baojoside I, 3 g of starch, 2 g of sucrose, 2 g of dextrin, and 500 mg of mannitol. The preparation of the tablet is carried out according to a conventional process.

Embodiment 3

[0041] An injection for treating rheumatoid arthritis and osteoporosis, the specific steps of which are as follows:

[0042] The injection components were weighed according to the following formula: baojoside I 20mg, lactic acid 5mg, lactose 8mg, glycine 5.5mg, mannitol 5mg, and sterile saline for injection 50ml. The injections were prepared according to conventional techniques.

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PUM

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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to application of baohuoside I in preparation of a medicine for treating rheumatoid arthritis and osteoporosis, and further relates to the medicine for treating the rheumatoid arthritis and the osteoporosis, the active ingredient of the medicine comprises baohuoside I, and the concentration of the baohuoside I in the medicine is 0.5-5 mu M. The baohuoside I inhibits osteoclast differentiation by inhibiting an Nf-kb signal channel and regulating an autophagy system, and is used for treating rheumatoid arthritis and osteoporosis. As a traditional Chinese medicine monomer, the invention develops a new application for the baohuoside I preparation, has important significance for treating rheumatoid arthritis and osteoporosis, and provides a new thought for promoting bone formation and inhibiting clinical treatment of joint inflammation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to the application and medicine of baohuoside I in the preparation of medicines for treating rheumatoid arthritis and osteoporosis. Background technique [0002] Osteoporosis (OP), the most common bone disease, is a systemic bone disease characterized by low bone mass and damage to the microarchitecture of bone tissue, resulting in increased bone fragility and susceptibility to fracture. With the aging of the population, osteoporosis has become an important public health problem in my country. The prevalence rate of osteoporosis in the population over 50 years old in my country is 20.7% for women and 14.4% for men. It is estimated that there were nearly 70 million osteoporosis patients in my country in 2006, and more than 200 million people suffered from osteopenia. Inhibiting bone resorption and promoting bone formation are the main therapeutic measures used ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P19/02A61P37/02A61P19/10
Inventor 张锦芳麦泳欣李志鹏
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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