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X-ray developable molecule, embolism microsphere and preparation method of X-ray developable molecule

An X-ray and molecular technology, applied in the fields of X-ray developable molecules, embolizing microspheres and their preparation, can solve problems such as harsh conditions, and achieve the effects of short reaction time, high yield, and easy intraoperative operation.

Active Publication Date: 2022-04-01
SHANGHAI HUIHE HEALTHCARE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method needs to use highly toxic organic solvents such as NMP and THF when synthesizing microspheres, and the reaction system needs to strictly remove water, so the conditions are relatively harsh.

Method used

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  • X-ray developable molecule, embolism microsphere and preparation method of X-ray developable molecule
  • X-ray developable molecule, embolism microsphere and preparation method of X-ray developable molecule
  • X-ray developable molecule, embolism microsphere and preparation method of X-ray developable molecule

Examples

Experimental program
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Effect test

preparation example Construction

[0058] Preparation Example 1 Preparation of polyvinyl alcohol embolization microspheres:

[0059] S1. Add 10 g of polyvinyl alcohol with a weight average molecular weight of 67,000 into 100 mL of purified water, and dissolve completely at 90° C. Add 5g of N-(2,2-dimethoxyethyl)-2-acrylamide and 42mL of concentrated hydrochloric acid, and react at 30°C for 8h. After the reaction, the pH of the reaction system was adjusted to 7 with sodium hydroxide solution. Finally, the solution was concentrated to a viscosity equal to 2200 cps to obtain a microsphere intermediate.

[0060] S2. 15g of the above-mentioned microsphere intermediate, 3g of 2-acrylamide-2-methylpropanesulfonic acid sodium salt and 0.75g of potassium persulfate were completely dissolved in 5mL of deionized water. Add 219 mL of butyl acetate and 1.5 g of cellulose acetate butyrate, and finally add 0.75 g of tetramethylethylenediamine under a nitrogen atmosphere, and react at 65° C. for 6 h. After the reaction, fil...

preparation example 3

[0064] Preparation Example 3 Preparation of sodium alginate embolization microspheres:

[0065] S1. Add 10 g of sodium alginate with a weight average molecular weight of 200,000 into 100 mL of purified water, and dissolve completely at 90° C. Add 2g of N-acrylamidoacetaldehyde and 16mL of concentrated hydrochloric acid, and react at 20°C for 6h. After the reaction, the pH of the reaction system was adjusted to 8 with sodium hydroxide solution. Finally, the solution was concentrated to a viscosity equal to 2000 cps to obtain a microsphere intermediate.

[0066] S2. Dissolve 10 g of the above-mentioned microsphere intermediate, 1 g of potassium 3-sulfopropyl methacrylate and 0.2 g of ammonium persulfate in 10 mL of deionized water. Then add 63.2mL cyclohexane and 0.5g Tween 20, finally add 0.2g N,N-dimethylaniline under nitrogen atmosphere, and react at 60°C for 4h. After the reaction, filter and wash with ethyl acetate, acetone and deionized water to obtain calcium alginate ...

preparation example 5

[0070] Preparation Example 5 Preparation of Sodium Hyaluronate Microspheres:

[0071] S1. Take 20g of hyaluronic acid sodium salt with a weight average molecular weight of 140,000, add it to 50g of water, heat to 80°C, stir for 2h, add 0.4g of N-(2,2-dimethoxyethyl)-2-acrylamide With 8mL of concentrated hydrochloric acid, react at 35°C for 3h. After the reaction, the pH of the reaction system was adjusted to 7.3 with sodium hydroxide solution. Finally, the solution was concentrated to a viscosity equal to 2000 cps to obtain a microsphere intermediate.

[0072] S2. Dissolve 20 g of the above-mentioned microsphere intermediate, 1.5 g of sodium acrylate and 0.2 g of sodium persulfate in 10 mL of deionized water. Add 180 mL of butyl acetate and 1.68 g of Span 20, and finally add 0.32 mL of triethylamine under an inert gas atmosphere, and react at 65° C. for 6 h. After the reaction, filter and wash with ethyl acetate, acetone and deionized water to obtain hyaluronic acid microsp...

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Abstract

The invention provides an X-ray developable molecule, an embolism microsphere and a preparation method of the X-ray developable molecule, and belongs to the technical field of medical materials.The preparation method comprises the following steps that 1, the X-ray developable molecule is prepared, the molecule is obtained by reacting a molecule with an amino group and an aldehyde, hemiacetal or acetal structure with an iodobenzene derivative, the X-ray developable molecule has an amide structure; and 2, connecting the X-ray developable molecules with the microspheres taking the polyhydroxy polymer as a main chain to prepare the X-ray developable embolism microspheres. The microsphere provided by the invention has X-ray developing property and drug loading property, the preparation method is simple, a doctor can directly observe the part where an embolism material reaches under X-ray fluoroscopy, intraoperative operation is facilitated, the embolism degree is easy to master, and various complications in the intravascular treatment process are effectively avoided.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an X-ray imageable molecule, an embolism microsphere and a preparation method thereof. Background technique [0002] In recent years, interventional embolization has played an increasingly important role in clinical medicine, especially in the treatment of tumors rich in blood vessels such as liver cancer, and has become more and more widely used in the treatment of tumors that cannot be surgically removed. Preferred alternative. Embolization microspheres are currently one of the most common embolization carriers, and have received more and more attention because of their high targeting to specific tissues and organs, good embolism, combination with chemotherapy drugs, and slow release of drugs. . At present, commercially available microspheres (such as DC Bead, CalliSphere, etc.) have uniform size, smooth surface, good stretchability and elasticity, good hydrophilici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/83C07C237/46C07C233/76C07C231/02A61L24/00A61L24/04
CPCA61L24/00A61L24/04C07C231/02C07C233/76C07C233/83C07C237/46A61K49/0438A61L24/001A61L24/06A61L24/08A61L2300/202
Inventor 张雪非雷宸一王冰清
Owner SHANGHAI HUIHE HEALTHCARE TECH CO LTD
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