Method for evaluating likelihood of onset or progression of transplanted kidney chronic rejection and chronic kidney disease, test kit, and pharmaceutical composition

A technology for chronic kidney disease and chronic rejection, applied in drug combinations, biochemical equipment and methods, allergic diseases, etc., can solve problems such as the functional role and expression level of SYT17 protein that have not yet been found

Pending Publication Date: 2022-03-18
HOKKAIDO UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, no reports have been found on the functional role and expression changes of SYT17 protein in chronic kidney disease and chronic rejection

Method used

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  • Method for evaluating likelihood of onset or progression of transplanted kidney chronic rejection and chronic kidney disease, test kit, and pharmaceutical composition
  • Method for evaluating likelihood of onset or progression of transplanted kidney chronic rejection and chronic kidney disease, test kit, and pharmaceutical composition
  • Method for evaluating likelihood of onset or progression of transplanted kidney chronic rejection and chronic kidney disease, test kit, and pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0110] experimental method

[0111] 1) Patient and urine sample

[0112] With permission from the Ethics Committee of Hokkaido University Hospital, total urine was obtained from healthy volunteers, chronic kidney disease (CKD) patients, and kidney transplant (KTx) patients between 2016 and 2019. Urine collection for KTx patients was performed at the time of procedural biopsy, excluding urine at the time of needle (episode) biopsy. Urine was centrifuged at 1,500 rpm for 5 minutes, and the supernatant was collected and stored at -80°C.

[0113] It should be noted that all KTx patients received standard immunosuppressive therapy of prednisone, mycophenolic acid, tacrolimus or cyclosporine. In addition, according to the histological results of procedural biopsy, KTx patients were divided into normal histology group (NED, n=20) and fibrosis group (interstitial fibrosis and interstitial fibrosis) based on Banff classification (2017). atrophy), IF / TA, n=19), calcineurin toxicity...

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Abstract

Provided is a method for evaluating the likelihood of the onset or progression of transplanted kidney chronic rejection or chronic kidney disease in a subject, wherein the amount of SYT17 protein in a urine-derived sample collected from the subject is used as an index. Furthermore, the present invention provides a pharmaceutical composition for preventing and/or treating chronic rejection of transplanted kidney or chronic kidney disease, comprising at least one substance selected from the group consisting of a specific antibody against SYT17, a derivative thereof, and an inhibitory nucleic acid against SYT17, and also comprising at least one substance selected from the group consisting of a specific antibody against SYT17, a derivative thereof, and an inhibitory nucleic acid against SYT17. Provided is a test kit for evaluating the likelihood of the onset or progression of transplanted kidney chronic rejection or chronic kidney disease, the test kit comprising an antibody specific to SYT17 or a derivative thereof.

Description

technical field [0001] The present invention relates to a method for evaluating the possibility of onset or progression of chronic rejection of transplanted kidney or chronic kidney disease, a test kit for the evaluation, and a medicament for preventing and / or treating chronic rejection of transplanted kidney or chronic kidney disease combination. Background technique [0002] Chronic kidney disease (Chronic Kidney Diseases, CKD) refers to: either or both of kidney damage represented by proteinuria and renal function decline as an indicator of glomerular filtration rate have lasted for more than 3 months 1 in every 8 adults in Japan suffers from the disease. Once the symptoms of chronic kidney disease progress and reach end-stage renal failure, there is no hope for the effect of drug treatment, and most patients have to undergo artificial dialysis. Artificial dialysis is a symptomatic therapy, so patients with end-stage renal failure need to continue to receive artificial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68A61K39/395A61K31/7088A61K31/713A61P13/12A61P37/06
CPCG01N33/6893C07K16/18A61K31/7088A61K31/713A61P13/12A61P37/06G01N2800/245G01N2800/347G01N2333/47G01N2333/70596A61K2039/505C12N2310/14C12N15/1138C12N2320/30A61K45/00A61K31/7105C07K16/28C12N15/113C12Q1/66
Inventor 村上正晃上村大辅高田祐辅
Owner HOKKAIDO UNIVERSITY
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