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Application of tetrahydroberberrubine in preparation of medicine for preventing or treating intestinal adhesion diseases

A tetrahydroberberine and drug technology, applied in the field of biomedicine, can solve the problems of heavy economic burden of medical expenses, increased risk of intestinal infection, prolonged recovery time, etc., achieve excellent preventive and therapeutic effects, and improve intestinal adhesions , the effect of inhibiting expression

Pending Publication Date: 2022-03-15
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When adhesions occur, although repeated operations can dissolve the adhesions, it will lead to serious complications such as intestinal tissue damage, prolonged postoperative recovery time, and conversion from laparoscopy to open surgery
In addition, adhesion-related complications impose a heavy financial burden on medical costs, especially when intestinal tissue is damaged after surgery
[0004] However, it is unavoidable that there is an increased risk of intestinal infection due to repeated enteral procedures, including adhesiolysis

Method used

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  • Application of tetrahydroberberrubine in preparation of medicine for preventing or treating intestinal adhesion diseases
  • Application of tetrahydroberberrubine in preparation of medicine for preventing or treating intestinal adhesion diseases
  • Application of tetrahydroberberrubine in preparation of medicine for preventing or treating intestinal adhesion diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 4

[0081] Embodiment 1 Tetrahydroberbererythine (THBru) intragastric administration of LD to mice 50 determination

[0082] 1. Experimental method:

[0083] Determination of LD of tetrahydroberbererythine in mice administered by Bilss method 50 . The specific method is as follows: take 30 Kunming mice, half male and half female, body weight (18-22g), and the mice are fasted for 16 hours before the experiment. They are randomly divided into 6 groups, 5 mice in each group, and separated according to the dosage from high to low. Cages were housed, weighed and registered, and mice were marked with ear tags. Take the concentrated solution that the No. 8 mouse gavage needle can just pass through as the maximum concentration of administration, that is, 100g / kg, according to the dose ratio of 5, 0.032g / kg, 0.16g / kg, 0.8g / kg, 4g / kg kg, 20g / kg, 100g / kg orally. Immediately after administration, observe the appearance signs, behavioral activities, mental state, appetite, stool and color...

Embodiment 2 4

[0086] Example 2 Tetrahydroberberine (THBru) inhibits postoperative intestinal adhesion and inhibits the expression of inflammatory factors

[0087] 1. Experimental method

[0088] Healthy male Wistar rats (200-220g body weight) were randomly divided into: Sham control group, Surgery group, THBR-1 group (0.75mg / mL), THBR-2 (1.5mg / mL) group and Interceed biofilm group. All rats were intraperitoneally anesthetized with sodium pentobarbital (3%), and the concentration was 0.15mL / 100g body weight; after the abdomen of the rats was shaved and depilated with depilatory cream, they were wiped clean with 75% alcohol cotton; after the abdomen was dry, A 3 cm anterior midline ventral laparotomy was performed through the abdominal wall and peritoneum to gain access to the abdominal cavity, and the cecum was separated and removed; the surface of the cecum was wiped with a toothbrush to create a bleeding surface, while the abdominal wall adjacent to the cecum was destroyed with a scalpel, ...

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Abstract

The invention relates to application of tetrahydroberberrubine in preparation of a medicine for preventing or treating intestinal adhesion diseases. Due to the fact that abdominal adhesion can cause bleeding, colorectal obstruction, female infertility and the like, existing treatment modes are laparoscopes or biological barrier material biological membranes, however, due to high cost and more serious tissue damage, postoperative tissue healing is troubled. Tetrahydroberberrubine has good prevention and treatment effects on abdominal adhesion, especially intestinal adhesion, and can inhibit expression of inflammatory factors and reduce inflammatory response at the same time. Therefore, tetrahydroberberrubine is suitable for prevention and treatment of abdominal adhesion, especially intestinal adhesion diseases.

Description

technical field [0001] The invention belongs to the field of biomedicine, and the invention relates to the application of a drug in the prevention or treatment of diseases, in particular to the application of tetrahydroberberubine in the preparation of prevention or treatment of abdominal adhesions, especially intestinal adhesions. Background technique [0002] Postoperative intestinal adhesions are common long-term sequelae after abdominal surgery, increasing postoperative morbidity. Usually refers to abnormal adhesions, causing a series of complications in many patients. When patients are treated for intestinal adhesions, the formation of adhesions can lead to exacerbation or recurrence, and the mortality rate will increase significantly, suggesting the need to prevent the formation of adhesions. Due to the high probability of intestinal adhesions after abdominal surgery, up to 90% of patients develop adhesions after abdominal surgery. Severe cases require laparotomy for...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P1/00A61P29/00
CPCA61K31/4375A61P1/00A61P29/00
Inventor 张勇杨宝峰韩维娜刘鑫刘亨
Owner HARBIN MEDICAL UNIVERSITY
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