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Schefflera arboricola dropping pill with nerve soothing effect and preparation method of seven-leaf nerve soothing dropping pill

A technology of Aescin and Andi Pills, which is applied in the field of pharmaceuticals, can solve problems such as poor curative effect, poor bioavailability, and quality fluctuations between batches, and achieve the goal of promoting reduction, good compatibility, and high bioavailability Effect

Active Publication Date: 2022-03-11
YUNNAN JINQI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of poor curative effect or poor bioavailability and quality fluctuations between batches in Qiye Shen'an dripping pills and related preparations in the prior art, a more excellent efficacy of Qiye Shen'an dripping pills with calming effect and its The preparation method is very necessary

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Aescin dropping pills, in parts by weight, raw materials include: 10 parts of Panax notoginseng total saponins, 5 parts of ginkgolides, 1 part of N-acetylneuraminic acid, 1.2 parts of lutein ester, 82 parts of matrix and 4 parts oil phase. Wherein the matrix is ​​polyethylene glycol 4000, and the oil phase is soybean oil, sunflower oil and maple seed oil with a weight ratio of 5:2:2.

[0027] The preparation method of the above-mentioned Aescin Dropping Pills comprises the following steps: after mixing the total saponins, ginkgolides and lutein esters of the prescribed dosage with an appropriate amount of water, stir in an 80°C water bath, dry to obtain the mixture A, and mix polyethylene The diol is heated and melted in a water bath at 80°C, and then the mixture A, N-acetylneuraminic acid and the oil phase are added, stirred and mixed evenly, and then made into dropping pills in a dropping pill machine.

Embodiment 2

[0029] Aescin dripping pills, the raw materials include: 12 parts of Panax notoginseng total saponins, 2 parts of ginkgolides, 3 parts of N-acetylneuraminic acid, 0.5 parts of lutein ester, 88 parts of matrix and 10 parts oil phase. Wherein the matrix is ​​polyethylene glycol 6000, and the oil phase is soybean oil, sunflower oil and ingot maple oil in a weight ratio of 8:1:5.

[0030] The preparation method of the above-mentioned Aescin Dropping Pills comprises the following steps: after mixing the total saponins, ginkgolides and lutein esters of the formula dosage with an appropriate amount of water, stir in a 100°C water bath, dry to obtain the mixture A, and mix polyethylene The diol is heated and melted in a water bath at 100°C, and then the mixture A, N-acetylneuraminic acid and the oil phase are added, stirred and mixed evenly, and then made into dropping pills in a dropping pill machine.

Embodiment 3

[0032] Aescin dripping pills, the raw materials include: 11 parts of Panax notoginseng total saponins, 4 parts of ginkgolides, 2.8 parts of N-acetylneuraminic acid, 0.9 parts of lutein ester, 85 parts of matrix and 6 parts oil phase. Wherein the matrix is ​​polyethylene glycol 6000, and the oil phase is soybean oil, sunflower oil and ingot maple oil in a weight ratio of 6:1:3.

[0033] The preparation method of the above-mentioned Aescin Dropping Pills comprises the following steps: after mixing the total saponins, ginkgolides and lutein esters of the formula dosage with an appropriate amount of water, stir in a 90°C water bath, dry to obtain the mixture A, and mix polyethylene The diol is heated and melted in a water bath at 90°C, and then the mixture A, N-acetylneuraminic acid and the oil phase are added, stirred and mixed evenly, and then made into dropping pills in a dropping pill machine.

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Abstract

The invention provides a seven-leaf nerve-calming dropping pill with a nerve soothing effect and a preparation method thereof, and relates to the technical field of medicines, the seven-leaf nerve-calming dropping pill comprises the following raw materials: panax notoginseng leaf total saponins, bilobalide, N-acetylneuraminic acid, lutein ester, a matrix and an oil phase. All the raw materials have good compatibility, the bioavailability can be improved while the reduction of the panax notoginseng leaf total saponins is realized, and the improvement of the effects of soothing the nerves, helping sleep and relieving pain of the medicament is promoted.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a Qiye Shen'an dripping pill with an effect of calming the nerves and a preparation method thereof. Background technique [0002] Aescin Dropping Pills is a Chinese patent medicine, which is a light yellow to light brown drop pill. The main ingredient of the currently listed Aescin Dropping Pills is total saponins of Panax notoginseng, and the auxiliary material is ethylene glycol 6000. The effect of promoting blood circulation and relieving pain can be used clinically to treat symptoms such as heart-qi deficiency, insomnia and heart palpitations. The related patents involved are recorded in CN02134076.5. Compared with the problems of slow dissolution rate, poor bioavailability and large fluctuations in drug quality between different batches of Qiye Shen'an tablets, Qiye Shen'an dripping pills have the advantages of simple preparation process, short process cycle, high product...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/20A61K47/10A61K47/44A61P9/06A61P25/20A61P29/00A61K31/23A61K31/365A61K31/7012
CPCA61K36/258A61K31/7012A61K31/365A61K31/23A61K9/2031A61K9/2013A61P25/20A61P29/00A61P9/06A61K2300/00Y02A50/30
Inventor 张云生
Owner YUNNAN JINQI PHARMA
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