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Needle and medicine integrated hydrogel microneedle

A hydrogel and microneedle technology, applied in the field of medicine, can solve problems such as insufficient drug loading and unresolved release problems, increase the number of mast cells and the degranulation rate of mast cells, prolong the writhing incubation period, and reduce writhing The effect of body scoring

Active Publication Date: 2022-03-08
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] If cinnamon oil is attached to the microneedle body for acupuncture treatment, the drug loading may be insufficient; if it is contained in the needle body, the release problem in the body not resolved

Method used

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  • Needle and medicine integrated hydrogel microneedle
  • Needle and medicine integrated hydrogel microneedle
  • Needle and medicine integrated hydrogel microneedle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation of embodiment 1 cinnamon oil nanocapsules

[0049] 1.1 Extraction of cinnamon oil

[0050] Refer to the cinnamon medicinal material stipulated in the 2020 edition of "Chinese Pharmacopoeia", weigh 200.2g of cinnamon medicinal material, crush it into a 20-mesh coarse powder, add 8 times the amount of water, soak for 1h, extract by steam distillation at 200°C for 6h, and collect volatile oil to obtain 3mL Cinnamon essential oil. Using HPLC detection, the cinnamon aldehyde content in cinnamon volatile oil is 93.1±4.45%, which meets the quality standards for cinnamon oil (Cinnamon Oil, CIO) in the 2020 edition of "Chinese Pharmacopoeia".

[0051] 1.2 Preparation of cinnamon oil nanocapsules

[0052] Weigh 60mg of sodium alginate and add purified water to 100mL to prepare a concentration of 0.6mg·mL -1 The solution was heated at 60°C and stirred at 300rpm for 30min until dissolved, then 1% acetic acid aqueous solution was added to adjust the pH to 5.5, and...

Embodiment 2

[0056] Example 2 Preparation of hydrogel microneedles loaded with cinnamon oil nanocapsules

[0057] 1.3 Preparation of hydrogel microneedles loaded with cinnamon oil nanocapsules

[0058] Weigh 4g of gelatin, add 15mL of purified water, heat at 55°C, and stir (300rpm) for 1h until completely dissolved. Weigh 160 mg of tannic acid, add 5 mL of purified water, and stir at 300 rpm to dissolve. The tannic acid solution was slowly added dropwise to the gelatin solution, the pH was adjusted to 5.5 with 1% sodium hydroxide solution, and the reaction was heated at 55°C for 4h. Add 400 mg of glycerin to the gelatin-tannic acid solution and stir evenly to obtain a hydrogel microneedle matrix.

[0059] Take 20mL cinnamon oil nanocapsule solution, stir and mix with 2mL hydrogel microneedle matrix, take 1mL and cast it in a clean microneedle mold, place it in a vacuum environment of –0.08mPa for 15min, scrape off the upper layer of matrix that has not been molded, and add New matrix so...

Embodiment 3

[0060] Example 3 Evaluation and characterization of hydrogel microneedles loaded with cinnamon oil nanocapsules (HFMNs-CIO@NCs)

[0061] 3.1 Morphological characterization of HFMNs-CIO@NCs

[0062] The dried HFMNs-CIO@NCs were taken, and the surface was evenly sprayed with gold powder, and placed under a scanning electron microscope under vacuum conditions for morphological observation.

[0063] figure 2 It is the scanning electron micrograph of the hydrogel microneedle of the cinnamon oil-loaded nanocapsule prepared in Example 3 of the present invention, wherein, the magnification of A is 100 times, and the magnification of B is 350 times. Depend on figure 2 It can be seen that the demoulding rate of HFMNs-CIO@NCs is 100%, and the needle tip is intact after demoulding. The needle body is pyramid-shaped, consisting of four-sided cone-shaped needle bodies, with uniform base thickness and neat array arrangement. The microneedle patch is a square with a side length of 1.4 cm...

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Abstract

The invention relates to the technical field of medicines, and discloses a needle and medicine integrated hydrogel microneedle. A microneedle matrix is hydrogel formed by a gelatin and tannic acid cross-linked product, a drug is entrapped in the matrix, and the drug is a cinnamon oil nanocapsule. The cinnamon oil nanocapsule hydrogel microneedle (HFMNs-CIOs-NCs) can better entrap cinnamon oil nanocapsules (CIOs-NCs) and deliver the CIOs-NCs to the deep layer of the skin in the acupoint region, the effect of warming the middle-jiao for dispelling cold of cinnamon oil is fully played, meanwhile, the microneedle absorbs water to swell, the tissue in the Shenque acupoint region can be stimulated, the acupoint region effect is stimulated, and the effect of the CIOs-NCs in the acupoint region is stimulated. The cold coagulation symptom of a cold coagulation and blood stasis type dysmenorrhea model rat is improved. The needle-medicine integrated hydrogel microneedle can be used for various entrapment medicines and preparations thereof, is further used for clinical treatment of acupoint therapy, and has clinical popularization and use values.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a hydrogel microneedle integrating acupuncture and medicine. Background technique [0002] The theory of traditional Chinese medicine believes that acupoints (acupoints) are special parts where Qi and blood flow into and out of the viscera and meridians, and acupoints are closely connected with deep tissues and organs and communicate with each other. Stimulating the acupoints of the human body through acupuncture, massage, drug administration, etc. can dredge the meridians, reconcile yin and yang, promote qi and blood circulation, stimulate the effect of acupoints, and achieve the purpose of strengthening the body, eliminating pathogens, and preventing and curing diseases. Umbilical drug administration is one of the commonly used umbilical therapy methods in traditional Chinese medicine. Traditional Chinese medicine believes that after the drug is administered at th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/42A61K47/22A61K36/54A61K9/51A61K47/36A61P15/00A61P29/00A61M37/00A61H39/00
CPCA61K9/0021A61K47/42A61K47/22A61K36/54A61K9/5161A61P15/00A61P29/00A61M37/0015A61H39/00A61M2037/0023A61M2037/0046A61M2037/0053A61H2201/105Y02A50/30
Inventor 张永太冯年平侯晓琳王志郭腾
Owner SHANGHAI UNIV OF T C M
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