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Water-soluble disinfecting composition comprising chlorhexidine or derivative thereof and having improved antibacterial durability, and fibrous disinfectant comprising same

A water-soluble, composition technology, applied in the direction of topical antibacterial agents, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of reduced antibacterial durability, low solubility and stability, etc. Excellent absorption efficiency, the effect of improving potential toxicity

Pending Publication Date: 2022-03-01
HUONS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] As described above, various studies have been conducted on water-soluble disinfecting compositions comprising chlorhexidine or derivatives thereof, which have limitations of low solubility and stability in an aqueous phase, in particular, When a water-soluble disinfectant composition containing chlorhexidine or a derivative thereof is applied to the skin, there is a problem that antibacterial durability is reduced, and research for solving it is required

Method used

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  • Water-soluble disinfecting composition comprising chlorhexidine or derivative thereof and having improved antibacterial durability, and fibrous disinfectant comprising same
  • Water-soluble disinfecting composition comprising chlorhexidine or derivative thereof and having improved antibacterial durability, and fibrous disinfectant comprising same
  • Water-soluble disinfecting composition comprising chlorhexidine or derivative thereof and having improved antibacterial durability, and fibrous disinfectant comprising same

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Embodiment approach

[0030] Hereinafter, the present invention will be described in detail.

[0031] Water-soluble disinfectant composition with improved antibacterial durability

[0032] The present invention provides a water-soluble disinfectant composition with improved antibacterial durability, which comprises chlorhexidine or a derivative thereof and a silicon-based emulsifier.

[0033] The "water-soluble disinfectant composition" in this specification is an external preparation containing a water-soluble solvent, and is characterized by not containing an alcoholic solvent. After the above-mentioned water-soluble disinfectant composition is applied to the human body such as the skin to be disinfected, the water-soluble solvent is volatilized to improve the skin-friendly effect, and the remaining components that have not been volatilized form a stable film on the human body such as the skin to be disinfected and act as a protective film. to disinfection. Moreover, the above-mentioned water...

Embodiment 1～ Embodiment 10 and comparative example 1～ comparative example 3

[0058] A sanitizing composition was prepared by the composition of Table 1 below. Specifically, add chlorhexidine gluconate solution (20%) (source: MEDICHEM S.A., Spain) as main component; Simethicone emulsion (source: DOW CORNING Corp., U.S.) as silicon-based emulsifier; PEG-23 glycerin coconut oil Ester (source: Protameen Chemical, USA) was used as amphiphilic stabilizer; concentrated glycerin (source: SSPHARM, Korea) was used as softener; polysorbate 20 (source: Cawcorporation, Japan) was used as surfactant; tartaric acid and hydrochloric acid were used as pH value regulator; or ethanol as an alcoholic solvent and dissolved, and purified water was added to make the final volume 100 ml, and then filtered with a 0.2 μm membrane filter to prepare a disinfectant composition. At this point, the pH of the sanitizing composition is maintained at 4.5 to 6.5.

[0059] Table 1

[0060]

[0061]

experiment example 1

[0062] Experimental Example 1: Measure the 50% cumulative mass particle size of the particles in the disinfectant composition Small distribution diameter, dispersion and zeta potential

[0063] As the silicon-based emulsifier in the sanitizing composition prepared in embodiment 1~embodiment 6 and comparative example 1, in order to make the content optimization of simethicone emulsion, in embodiment 1~embodiment 6 and comparative example 1 The prepared disinfectant composition was used as the object, and the 50% cumulative mass particle size distribution diameter, degree of dispersion, and zeta potential of the nanoparticles were measured by a Zeta-sizer, and the results are shown in Table 2.

[0064] Table 2

[0065]

[0066] As shown in Table 2, in the case of the disinfecting composition prepared in Examples 1 to 6, different from the disinfecting composition prepared in Comparative Example 1, Simethicone emulsion must be included as a silicon-based emulsifier. It is c...

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Abstract

The present invention relates to a water-soluble disinfecting composition having improved antibacterial durability and a fiber-type disinfecting agent comprising the same, the water-soluble disinfecting composition having improved antibacterial durability comprising chlorhexidine or a derivative thereof and a silicon-based emulsifier. According to the present invention, the chlorhexidine or the derivative thereof is well dispersed in an aqueous phase in a state having high solubility and stability, thereby having excellent absorption efficiency when applied to the skin and maximizing the final cumulative release amount of chlorhexidine or the derivative thereof. Moreover, by using the polyglycerol fatty acid ester, the slow release of the chlorhexidine or the derivative thereof can be realized, and the antibacterial effect can be maintained for a long time.

Description

technical field [0001] The present invention relates to a water-soluble disinfectant composition comprising chlorhexidine or a derivative thereof with improved antibacterial durability and a fiber-type disinfectant comprising the same. Background technique [0002] Chlorhexidine has a wide range of bactericidal and bacteriostatic effects on Gram-negative bacteria and Gram-positive bacteria. The substance is bisbiguanide, widely used as acetate, gluconate and hydrochloride. The main chemical names used are 1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide] acetate digluconate and dihydrochloride salts, consisting of substances stabilized with salts of each organic acid . [0003] Among them, the substance tested as the most stable organic acid salt is gluconate, which is widely used as a bactericidal preservative. According to its content, it has a strong bactericidal effect in high concentrations, and in low concentrations, it is harmful to Pseudomonas and Mycobacterium b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/70A61K9/00A61K31/155A61K47/14A61K47/34A61P31/02
CPCA61K9/08A61K9/70A61K9/00A61K31/155A61K47/14A61K47/34A61P31/02A61K9/7007A61K9/0014A01P1/00A01N47/44A01N25/30
Inventor 金倍永李东日李恩卿康珉喜赵在珉吴畯教
Owner HUONS
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