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A kind of soft tissue repair collagen membrane and preparation method thereof

A collagen membrane and soft tissue technology, used in tissue regeneration, prosthesis, medical science, etc., can solve the problems of easy stratification, easy generation of air bubbles, difficult to grasp the surgical method, etc., to avoid stratification and improve the effect of uniformity

Active Publication Date: 2022-05-03
TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some commonly used soft tissue surgical treatment methods, such as autologous connective tissue transplantation, free gingiva transplantation, etc., are difficult to master, and the postoperative effect is not expected, and it will add pain to the patient
However, the currently commonly used acellular dermal matrix (acellular dermal matrix, ADM) has the disadvantage of risk of disease transmission.
[0003] At the present stage, in the similar biofilm preparation methods, the uniformity of the slurry spraying is not good, the thickness of the slurry at different parts is quite different, and the spraying process is prone to produce air bubbles, resulting in uneven thickness and easy layering of the biofilm after the final freeze-drying. It is easy to produce holes on the surface, and the product surface structure is poor

Method used

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  • A kind of soft tissue repair collagen membrane and preparation method thereof
  • A kind of soft tissue repair collagen membrane and preparation method thereof
  • A kind of soft tissue repair collagen membrane and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] This embodiment provides a method for preparing a soft tissue repair collagen film, comprising the following steps:

[0033] (1) Add type I collagen to an acetic acid solution with a concentration of 0.2% (v / v) to prepare a collagen-acetic acid swelling solution, wherein the concentration of type I collagen is 0.3% (w / v);

[0034] (2) Add chondroitin sulfate sodium to the collagen-acetic acid swelling solution, and stir evenly to obtain a collagen-chondroitin sulfate sodium slurry with a pH of 2.0, wherein the concentration of chondroitin sulfate sodium is 2% (w / v);

[0035] (3) Defoaming the collagen-chondroitin sulfate sodium slurry, then pouring it into a stainless steel freeze-drying tray, and placing it in a vacuum freeze dryer for the first vacuum freeze-drying; Machine pressed into a collagen basement membrane with a thickness of 0.1 mm;

[0036] (4) Pour the collagen-chondroitin sulfate sodium slurry between the two layers of the collagen base film, and use a...

Embodiment 2

[0039] This embodiment provides a method for preparing a soft tissue repair collagen film, comprising the following steps:

[0040] (1) Add type I collagen to an acetic acid solution with a concentration of 0.6% (v / v) to prepare a collagen-acetic acid swelling solution, wherein the concentration of type I collagen is 1.0% (w / v);

[0041] (2) Add chondroitin sulfate sodium to the collagen-acetic acid swelling solution, and stir evenly to obtain a collagen-chondroitin sulfate sodium slurry with a pH of 4.0, wherein the concentration of chondroitin sulfate sodium is 10% (w / v);

[0042] (3) Defoaming the collagen-chondroitin sulfate sodium slurry, then pouring it into a stainless steel freeze-drying tray, and placing it in a vacuum freeze dryer for the first vacuum freeze-drying; Machine pressed into a collagen basement membrane with a thickness of 0.5 mm;

[0043] (4) Pour the collagen-chondroitin sulfate sodium slurry between the two layers of the collagen base film, and use ...

Embodiment 3

[0046] This embodiment provides a method for preparing a soft tissue repair collagen film, comprising the following steps:

[0047] (1) Add type I collagen to an acetic acid solution with a concentration of 0.4% (v / v) to prepare a collagen-acetic acid swelling solution, wherein the concentration of type I collagen is 0.6% (w / v);

[0048] (2) Add chondroitin sulfate sodium to the collagen-acetic acid swelling solution, and stir evenly to obtain a collagen-chondroitin sulfate sodium slurry with a pH of 3.0, wherein the concentration of chondroitin sulfate sodium is 6% (w / v);

[0049] (3) Defoaming the collagen-chondroitin sulfate sodium slurry, then pouring it into a stainless steel freeze-drying tray, and placing it in a vacuum freeze dryer for the first vacuum freeze-drying; Machine pressed into a collagen basement membrane with a thickness of 0.3mm;

[0050] (4) Pour the collagen-chondroitin sulfate sodium slurry between the two layers of the collagen base film, and use a ...

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Abstract

The invention relates to a soft tissue repair collagen film and a preparation method thereof. The preparation method comprises the following steps: adding type I collagen to the acetic acid solution to prepare a collagen-acetic acid swelling solution; then adding sodium chondroitin sulfate, stirring evenly to obtain a collagen-chondroitin sulfate sodium slurry; The collagen chondroitin sulfate sodium slurry is defoamed, then freeze-dried and pressed to obtain a collagen basement membrane; the collagen chondroitin sulfate sodium slurry is poured between two layers of the collagen base membrane, and Slurry is applied to make the thickness of the slurry uniform and smooth without air bubbles to obtain a pre-collagen film; the pre-collagen film is firstly subjected to secondary freeze-drying, and then sequentially cross-linked and sterilized to obtain the collagen film for soft tissue repair. Among them, the slurry defoaming process is added to reduce the phenomenon of holes and delamination on the membrane surface caused by air bubbles in the production process; and the use of a slurry coating device greatly improves the uniformity of the membrane thickness and avoids the occurrence of delamination.

Description

technical field [0001] The invention belongs to the technical field of regenerative medical materials, and relates to a soft tissue repair collagen film and a preparation method thereof. Background technique [0002] In clinical implant surgery, soft tissue insufficiency and defects often affect the later aesthetic restoration. Some commonly used soft tissue surgical treatment methods, such as autologous connective tissue transplantation and free gingiva transplantation, are difficult to master, and the postoperative effect is not expected, and it will add pain to the patient. However, the currently commonly used acellular dermal matrix (acellular dermal matrix, ADM) has the disadvantage of risk of disease transmission. [0003] At the present stage, in the similar biofilm preparation methods, the uniformity of the slurry spraying is not good, the thickness of the slurry at different parts is quite different, and the spraying process is prone to produce air bubbles, resulti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/24A61L27/20C08J5/18C08L89/00C08L5/08
CPCA61L27/24A61L27/20C08J5/18C08J2389/00C08J2405/08A61L2430/34C08L89/00C08L5/08
Inventor 黄果张伟孙冰冰
Owner TIANXINFU (BEIJING) MEDICAL APPLIANCE CO LTD
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