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Preparation method of hydrogel gauze capable of preventing blood adhesion

A hydrogel gauze and adhesion technology, applied in the direction of medical formula, bandages, plant fibers, etc., can solve the problems of pain, secondary bleeding, tearing wounds, etc., and achieve the effect of anti-seepage and hemostasis, excellent effect

Active Publication Date: 2022-02-15
GUANGZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When gauze is used to treat wounds, pressure is often used. This method will inevitably absorb blood, which will cause the gauze to stick to the wound. If the gauze is forcibly torn, it will often tear the wound, causing pain, and even secondary bleeding

Method used

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  • Preparation method of hydrogel gauze capable of preventing blood adhesion
  • Preparation method of hydrogel gauze capable of preventing blood adhesion
  • Preparation method of hydrogel gauze capable of preventing blood adhesion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This embodiment relates to a kind of anti-blood adhesion hydrogel gauze, and its preparation method comprises the following steps:

[0036] S1, take 0.06g photoinitiator and join in 2mL ethanol, stir to obtain photoinitiator solution;

[0037] S2. Weigh 2.4g acrylamide, 0.6g vinyl tris(2-methoxyethoxy)silane and 0.2g hydroxyl silicone oil respectively, and add them to 9g solvent (m 水 :m 丙三醇 =7:3), fully stirred for 30min-60min, added 300 μL of the photoinitiator solution described in step S1, and continued to stir for 10min;

[0038] S3. Weigh 0.3g of N-aminoethyl-3-aminopropylmethyldimethoxysilane into the solution obtained in step S2 and stir evenly;

[0039] S4. Pour the solution obtained in step S3 into a petri dish, cut the medical gauze into a suitable size and soak it in it for 30 minutes;

[0040] S5. Take out the soaked gauze and put it into an ultraviolet light curing machine to irradiate for 5 minutes to obtain the hydrogel gauze.

[0041] See attached ...

Embodiment 2

[0043] This embodiment relates to a kind of hydrogel gauze, and its preparation method is the same as that of Embodiment 1, the difference is that the types of silane coupling agents containing double bonds are different, but the molar weight remains the same, and the specific conditions are as follows:

Embodiment 3-6

[0045] This embodiment relates to a kind of hydrogel gauze, and its preparation method is the same as that of embodiment 1, the difference is that N-aminoethyl-3-aminopropylmethyldimethoxysilane is replaced by other types of silane coupling agents, But the molar weight is constant, and the specific conditions are as follows:

[0046]

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Abstract

The invention provides hydrogel gauze capable of preventing blood adhesion, and belongs to the technical field of biochemical engineering. The preparation method of the hydrogel gauze comprises the following steps: S1, adding a monomer and hydroxyl silicone oil into a solvent, and fully stirring and emulsifying to obtain a uniform emulsified solution; and adding a photoinitiator and N-aminoethyl-3-aminopropyl methyl dimethoxy silane, and fully stirring and mixing, so as to obtain a gel precursor solution, wherein the monomer is composed of a first monomer and a second monomer, the first monomer comprises acrylamide, and the second monomer comprises a silane coupling agent containing double bonds; S2, soaking gauze in the gel precursor solution, and enabling the soaked gauze to be subjected to light curing treatment to prepare the hydrogel gauze capable of preventing blood adhesion. The hydrogel gauze retains the softness and air permeability of original gauze, and meanwhile has a good anti-adhesion effect on solutions such as water, protein and blood.

Description

technical field [0001] The invention relates to the technical field of biochemical engineering, in particular to a preparation method of a blood-adherent hydrogel gauze. Background technique [0002] The traditional medical gauze is made of cotton yarn plain weave, bleached and degreased. The structure is sparse. The product is strictly sterilized by high temperature and high pressure. When gauze is used to treat wounds, pressure is often used. This method will inevitably absorb blood, which will cause the gauze to stick to the wound. If the gauze is forcibly torn, it will often tear the wound, causing pain, and even secondary bleeding. [0003] Textile coating is a polymer compound evenly coated on the surface of the fabric. It forms one or more layers of film on the surface of the fabric through adhesion, which can not only improve the appearance and style of the fabric, but also increase the function of the fabric. The fabric has special functions such as waterproof, wa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M15/356A61L15/24A61L15/42D06M101/06
CPCD06M15/3568A61L15/42A61L15/425A61L15/24A61L2400/04D06M2101/06C08L51/08Y02A50/30
Inventor 吴旭李云龙徐秀彬张铱淳于丹凤
Owner GUANGZHOU UNIVERSITY
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