N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound as well as preparation method and application thereof
A technology of cyclodextrin inclusion compound and phenylacetamide, which is applied in the field of N,N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound and its preparation, and mosquito repellent products. It can solve the problems of short effective time and unfriendliness of those who are allergic to ethanol, and achieve the effect of good effect, long effective time of mosquito repellent and rich source of raw materials
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[0046] The preparation method of N,N-diethyl-2-hydroxyl-2-phenylacetamide cyclodextrin inclusion compound, the method comprises the following steps:
[0047] (1) Take part of the water and add it to the reaction bottle, start stirring, weigh the β-cyclodextrin and auxiliary materials according to the proportion, add them to the reaction bottle, and stir to completely dissolve to form a mixed solution;
[0048] (2) Add N,N-diethyl-2-hydroxy-2-phenylacetamide to the mixed solution obtained in step (1), carry out inclusion reaction under stirring for 1-24 hours, add preservative after the reaction is completed and the remaining water, stirred and dissolved, filtered and bottled to obtain the N,N-diethyl-2-hydroxyl-2-phenylacetamide cyclodextrin inclusion compound.
[0049] Wherein, the temperature of the inclusion reaction is 10-50°C; preferably, the temperature of the inclusion reaction is 20-40°C; more preferably, the temperature of the inclusion reaction is 25-35°C.
Embodiment 1
[0052] This example provides a kind of N,N-diethyl-2-hydroxyl-2-phenylacetamide cyclodextrin inclusion complex made from the following raw materials: 30wt% main ingredient N,N-diethyl-2 -Hydroxy-2-phenylacetamide, 35 wt% hydroxypropyl-β-cyclodextrin, 15 wt% excipients and 1 wt% potassium sorbate (preservative), N,N-diethyl-2-hydroxy- 2-phenylacetamide is a crystal compound; the purity of the main material is 99.9%; the auxiliary material is povidone K30, and the balance is purified water.
[0053] The preparation method of N,N-diethyl-2-hydroxyl-2-phenylacetamide cyclodextrin inclusion compound, the method comprises the following steps:
[0054] (1) Take part of the water and add it to the reaction bottle, start stirring, weigh the hydroxypropyl-β-cyclodextrin and auxiliary materials according to the ratio, add the reaction bottle, and stir to completely dissolve to form a mixed solution;
[0055] (2) Add N,N-diethyl-2-hydroxy-2-phenylacetamide to the mixed solution obtained ...
Embodiment 2
[0057] This example provides a N,N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound made from the following raw materials: 4wt% main ingredient N,N-diethyl-2 -Hydroxy-2-phenylacetamide, 10wt% of hydroxypropyl-β-cyclodextrin, 5wt% of auxiliary materials, N,N-diethyl-2-hydroxyl-2-phenylacetamide is a crystal compound; The purity of the main material is 99.5%; the auxiliary material is mannitol, and the balance is purified water.
[0058] The preparation method of N,N-diethyl-2-hydroxyl-2-phenylacetamide cyclodextrin inclusion compound, the method comprises the following steps:
[0059] (1) Take part of the water and add it to the reaction bottle, start stirring, weigh the hydroxypropyl-β-cyclodextrin and auxiliary materials according to the ratio, add the reaction bottle, and stir to completely dissolve to form a mixed solution;
[0060] (2) Add N,N-diethyl-2-hydroxy-2-phenylacetamide to the mixed solution obtained in step (1), stir at 10°C for inclusion reac...
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