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Rosmarinus officinalis essential oil nanoemulsion gel, and preparation method and application thereof

A technology of rosemary essential oil and nano-emulsion, which is applied in the fields of pharmaceutical formulation, emulsion delivery, and medical preparations of non-active ingredients, etc. It can solve the problems of strong fluidity of nano-emulsion, achieve good drug-loading capacity, and be easy to spread , skin feel good effect

Pending Publication Date: 2022-01-21
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, essential oil drugs are made into nanoemulsions, although the bioavailability of essential oil drugs can be improved, but in the process of use, the nanoemulsions have strong fluidity and are not easy to adhere to the skin

Method used

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  • Rosmarinus officinalis essential oil nanoemulsion gel, and preparation method and application thereof
  • Rosmarinus officinalis essential oil nanoemulsion gel, and preparation method and application thereof
  • Rosmarinus officinalis essential oil nanoemulsion gel, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A nanoemulsion of rosemary essential oil, see figure 1 As shown, it is made from the following raw materials in weight ratio: polyoxyethylene castor oil 15.5wt%, absolute ethanol 15.5wt%, rosemary essential oil 6.9wt%, water 62.1wt%.

[0038] Above-mentioned rosemary essential oil nanoemulsion is to make according to the following steps:

[0039] Rosemary essential oil and deionized water are slowly added dropwise to the mixed solution of polyoxyethylene castor oil and absolute ethanol, the solution undergoes a phase transition process, from clear to turbid and then to clear, and rosemary essential oil nanoemulsion is obtained .

Embodiment 2

[0041] Same as Example 1, except that rosemary essential oil is 13.8wt%, water is 55.2wt%, Tween 80 is used instead of polyoxyethylene castor oil, and polyethylene glycol 400 is used instead of absolute ethanol.

Embodiment 3

[0043] Same as Example 1, except that Tween 20 was used instead of polyoxyethylene castor oil, and 1,2-propanediol was used instead of absolute ethanol.

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Abstract

The invention provides a Rosmarinus officinalis essential oil nanoemulsion gel, and belongs to the technical field of medicaments. The Rosmarinus officinalis essential oil nanoemulsion gel is prepared from the following raw materials in percentage by weight: 1-3.5 wt% of carbomer, 5-15 wt% of glycerol, 5.5-10.5 wt% of propylene glycol, 0.5-2.0 wt% of Rosmarinus officinalis essential oil nanoemulsion and the balance of water. The Rosmarinus officinalis essential oil nanoemulsion gel provided by the invention has a moisturizing effect, is likely to spread, is good in skin feeling, and plays an important role in a transdermal drug delivery system. Compared with a Rosmarinus officinalis essential oil product, the prepared gel preparation is small in irritation and high in stability, and bioavailability is greatly improved. The Rosmarinus officinalis essential oil nanoemulsion gel has a swelling property, thixotropy and adhesiveness, so that the adhesion of the nanoemulsion to the skin can be enhanced.

Description

technical field [0001] The invention belongs to the technical field of medicaments, and in particular relates to a rosemary essential oil nanoemulsion gel, a preparation method and an application thereof. Background technique [0002] Rosemary, Latin scientific name (Rosmarinus officinalis), is a dicotyledonous plant, Lamiaceae, Rosmarinus plant shrub, likes warm climates, and is native to Europe and the Mediterranean coast of northern Africa. According to literature records, rosemary was introduced into my country from the Western Regions in the seventeenth year of Emperor Wei Wen of the Three Kingdoms. Rosemary is an important spice, and its essential oil also has strong anti-inflammatory and antioxidant properties. Rosemary essential oil (REO) is a volatile component extracted from rosemary, mainly including monoterpenes and sesquiterpenes. At present, REO is mainly used in the fields of daily chemical industry, food and health care. [0003] REO is a colorless to pale...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/107A61K36/53A61K47/32A61P31/04A61P31/10A61P29/00
CPCA61K9/06A61K9/1075A61K9/0014A61K36/53A61K47/32A61P31/04A61P31/10A61P29/00Y02A50/30
Inventor 黄海英朱艳慧余海艳薛丙权李康吕田田崔荣洽
Owner HENAN UNIV OF CHINESE MEDICINE
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