Contact lens displaying improved vision attributes

A technology for contact lenses, visual attributes, used in reactive dyes, glasses/goggles, instruments, etc., to solve problems such as adverse effects on vision

Pending Publication Date: 2022-01-14
强生视力健公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, since HEV light forms part of the visible spectrum, complete absorption of HEV light may adversely affect vision

Method used

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  • Contact lens displaying improved vision attributes
  • Contact lens displaying improved vision attributes
  • Contact lens displaying improved vision attributes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0357] Embodiment 1—synthesis of 2-(2-cyanoacetamido) ethyl methacrylate (A) and methacrylic acid as shown in scheme 2 2-(2-cyano-2-(9H-thioxanthene-9-ylidene)acetamido)ethyl ester (B)

[0358]

[0359] Scenario 2

[0360] Stir methyl cyanoacetate (40 g, 0.4037 mol) and 25 mL of dichloromethane in a 500 mL three-necked round bottom flask equipped with a reflux condenser under nitrogen. 2-Aminoethanol (23.8 g, 0.3897 mol, ca. 0.97 eq.) was added to the solution via the addition funnel after which time the temperature rose and the methylene chloride began to reflux. After the exotherm ceased, external heat was applied to continue gentle reflux for a total of two hours, after which no ethanolamine was observed by thin layer chromatography.

[0361] The reaction can also be performed at room temperature and is complete within a few hours.

[0362] The mixture was cooled to room temperature, and all methylene chloride was evaporated under reduced pressure. The residual oi...

Embodiment 2

[0365] Embodiment 2—synthesis of 2-(2-cyanoacetamido) ethyl methacrylate (F) and N-(2-(2- Cyano-2-(9H-thioxanthene-9-ylidene)acetamido)ethyl)methacrylamide (G)

[0366]

[0367] Option 3

[0368] Stir methyl cyanoacetate (22 g, 0.22 mol) and 250 mL of dichloromethane in a 500 mL three-necked round bottom flask equipped with a reflux condenser under nitrogen. The solution was cooled in a water bath, and 1,2-diaminoethane (12 g, 0.2 mol, about 0.9 eq.) was added to the mixture. As the reaction progressed, the mixture became increasingly heterogeneous and the product fell out of solution. After stirring at room temperature for four hours, the volatiles were evaporated under reduced pressure, and the residue was washed with ethyl acetate on a sintered glass funnel and dried at 50 °C before further use. 1 H NMR (500MHz,D 2 O)δ2.74(2H,t,CH 2 NH 2 ),3.29(2H,t,CH 2 NH),3.38(2H,s,CH 2 CN).

[0369] 2-Aminoethylcyanoacetamide (12.7 g, 0.1 mol) and 12.0 g of sodium carbona...

Embodiment 3

[0371] Embodiment 3—Synthesis of 2-(2-cyanoacetoxy) ethyl methacrylate (K) and methacrylic acid as shown in scheme 4 2-(2-cyano-2-(9H-thioxanthene-9-ylidene)acetoxy)ethyl ester (L)

[0372]

[0373] Option 4

[0374] 2-(2-Cyanoacetoxy)ethyl methacrylate (K) was prepared by coupling cyanoacetic acid with 2-hydroxyethyl methacrylate as follows. Cyanoacetic acid (9 g, 0.106 mol) and 13 g of 2-hydroxyethyl methacrylate (HEMA) were stirred in 250 mL of dichloromethane, and ethyldimethylaminopropylcarbodiimide hydrochloride (EDC ) (20 g, 0.104 mol) was added to the suspension in 4 batches (5 g per batch). The mixture gradually became more homogeneous as the less polar derivative formed, and after the reaction was complete, the volatiles were evaporated under reduced pressure. The product was redissolved in a 25:75 (by weight) mixture of ethyl acetate and hexanes and extracted several times with deionized water to remove any remaining salts and unreacted HEMA. A small amount ...

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Abstract

Described are contact lenses that contain high energy visible (HEV) light absorbing compounds and their use for improving one or more vision attributes.

Description

[0001] related application [0002] This application claims priority to U.S. Patent Application Serial No. 16 / 938,117, filed July 24, 2020, and U.S. Provisional Patent Application Serial No. 62 / 893,996, filed August 30, 2019, which are incorporated by reference in their entirety This article. technical field [0003] The present invention relates to contact lenses comprising high energy visible (HEV) light absorbing compounds and their use for improving one or more visual properties. Background technique [0004] High-energy light from the sun, such as UV light and high-energy visible light, is known to be responsible for cell damage. While most radiation with wavelengths below 280nm is absorbed by the Earth's atmosphere, photons with wavelengths in the 280nm to 400nm range have been linked to a variety of eye diseases, including degenerative changes in the cornea, as well as age-related cataracts and macular degeneration. (See "Statement on Ocular Ultraviolet Radiation H...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02C7/04G02C7/10G02B5/22G02B1/04C08F290/06C08F230/08C08F220/20C08F222/20C08F220/38
CPCG02C7/049G02C7/104G02C7/108G02B5/223G02B1/043G02C7/10C08F290/068C08F230/085C08F220/20C08F222/102C08F220/387C09B62/44G02C7/04C08F220/1802C08L2666/70C09B23/0058C09B23/04
Inventor P·马丁J·R·比什J·坎农S·马哈德文D·D·赖特
Owner 强生视力健公司
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