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Radiotherapeutic microspheres

A technology of microspheres, therapeutic agents, applied in the field of hepatocellular carcinoma

Pending Publication Date: 2022-01-14
BOARD OF RGT THE UNIV OF TEXAS SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This allows for faster and more uniform ablation of the tumor, but studies have not shown any statistical difference in efficiency compared to radioembolization

Method used

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  • Radiotherapeutic microspheres

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Embodiment Construction

[0033] The following discussion is directed to various embodiments of the invention. The term "invention" is not intended to refer to any particular embodiment or otherwise limit the scope of the present disclosure. Although one or more of these embodiments may be preferred, the disclosed embodiments should not be interpreted, or otherwise used, as limiting the scope of the disclosure, including the claims. Furthermore, those skilled in the art will understand that the following description has broad application, and that any discussion of an embodiment is meant to be an example of such an embodiment only, and is not intended to imply that the scope of the present disclosure, including the claims, is limited to such an embodiment.

[0034] Embodiments relate to therapeutic and / or diagnostic alginate microspheres. Certain aspects relate to therapeutic alginate microspheres for intraarterial embolization therapy. In another aspect, the therapeutic alginate microspheres are rad...

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Abstract

Certain embodiments are directed to compositions comprising and method for producing alginate microspheres that contain liposomes encapsulating a variety of useful substances. Substances of note that can be encapsulated in liposomes and loaded into alginate microspheres include radiotherapeutics (e.g., rhenium-188), radiolabels (e.g., technetium-99m), chemotherapeutics (doxorubicin), magnetic particles (e.g., 10 m iron nanoparticles), and radio-opaque material (e.g., iodine contrast).

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Application Serial No. 62 / 851,915, filed May 23, 2019, the entire contents of which are incorporated herein by reference. [0003] Statement Regarding Federally Funded Research [0004] none. Background technique [0005] Hepatocellular carcinoma (HCC) is the most common type of liver cancer. It is the sixth most common type of cancer and the third most common cause of cancer death. HCC is particularly aggressive and has a low survival rate (five-year survival <5%), thus remaining an important public health problem globally (Global Data Intelligence Center-Pharma, URLpharma.globaldata.com / HomePage, 2019). HCC most often occurs in livers showing cirrhosis or scarring of the liver, which can be caused by a variety of factors, including hepatitis B infection, hepatitis C infection, chronic alcohol abuse, and common fungi that can grow on certain crops, such as corn ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/127A61P35/00
CPCA61P35/00A61K9/127A61K9/0019A61K9/5036A61K9/5089A61K9/1652A61K51/1244A61K51/1234A61K41/0052A61B17/12186A61K47/02A61N2005/1021
Inventor 威廉·T·菲利普斯瑞恩·比塔尔
Owner BOARD OF RGT THE UNIV OF TEXAS SYST
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