Preparation method of andrographolide sulfonate for controlling anaphylactoid reaction of traditional Chinese medicine injection

A technology of andrographolide, allergic reaction, applied in the direction of organic chemistry, etc., can solve the problems of allergic reaction, poor effect of andrographolide, poor uniformity, etc., to improve safety, ensure technical feasibility and progress. Effect

Pending Publication Date: 2021-12-31
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] CN1349986A discloses a water-soluble andrographolide sulfonation process, which involves the steps of reclaiming ethanol and suction filtration; in the production practice process, it is found that adding activated carbon to the preparation process of androgr...

Method used

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  • Preparation method of andrographolide sulfonate for controlling anaphylactoid reaction of traditional Chinese medicine injection
  • Preparation method of andrographolide sulfonate for controlling anaphylactoid reaction of traditional Chinese medicine injection
  • Preparation method of andrographolide sulfonate for controlling anaphylactoid reaction of traditional Chinese medicine injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Intermediate Filter Preparation

[0024] 1) Sulfonation: 100 grams of anhydrous ethanol is placed in a stainless steel barrel, and the chemical pure proportion of concentrated sulfate is 60 ml of concentrated sulfate of 1.84 at a temperature of 10 ° C -15 ° C, and then cool to room temperature after completion, once Add 100 grams of pendant insertion in the three mesh sieve, thoroughly stir well, place at room temperature;

[0025] 2) Middle sum: After 24 hours, 95% ethanol 100ml was mixed, and the temperature was 10 ° C on the cold water bath, and 50 ml of 50 ml of sodium hydroxide was about 130 ml of 5;

[0026] 3) Filtration: Add 95% ethanol 600 ml, stirred, and then filtered after 2 hours, and the filter residue was washed with 95% ethanol to the wash liquor almost colorless, and the filtrate and lotion were obtained.

Embodiment 2

[0027] Example 2 CN1349986A is prepared by a fluorenesulfides dry matter

[0028] 1) Sulfonation: 100 grams of anhydrous ethanol is placed in a stainless steel barrel, and the chemical pure proportion of concentrated sulfate is 60 ml of concentrated sulfate of 1.84 at a temperature of 10 ° C -15 ° C, and then cool to room temperature after completion, once Add 100 grams of pendant insertion in the three mesh sieve, thoroughly stir well, place at room temperature;

[0029] 2) Middle sum: After 24 hours, 95% ethanol 100ml was mixed, and the temperature was 10 ° C on the cold water bath, and 50 ml of 50 ml of sodium hydroxide was about 130 ml of 5;

[0030] 3) Filter: Add 95% ethanol 600 mL, stir well, and then filtered after 2 hours, the filter residue was washed with 95% ethanol to the wash liquor, and the filtrate and lotion were obtained.

[0031] 4) Recycling ethanol: Recycling ethanol and concentrates to a volume of about 200ml, and heat the water is heated to volatilize ethano...

Embodiment 3-31

[0034] Example 3-31: Preparation method of penetrant lactyl sulfides in control of traditional Chinese medicine injection allergic reactions

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Abstract

The invention discloses a preparation method of an andrographolide sulfonate for controlling anaphylactoid reaction of a traditional Chinese medicine injection. The content uniformity of andrographolide in the andrographolide sulfonate is controlled through the procedures of intermediate filtrate concentration, water precipitation, cooling, refrigeration, filtration, concentration, extraction and drying, so that the anaphylactoid reaction of a traditional Chinese medicine injection is effectively controlled.

Description

Technical field [0001] The present invention relates to the field of traditional Chinese medicine, and more particularly to the preparation method of controlling the perinotel lactide sulfides in which Chinese medicine injection allergic reactions. Background technique [0002] CN1349986A discloses a water-soluble molded lactone, which involves recovery of ethanol and drawing step; during production practice, it is found that the activated carbon is boiled during the preparation of the insertion of the incenselate, and the heat pickup filter is not complete. The raw material is not good, the uniformity is not strong, and the risk of allergic reactions in the incense of the incense sulfides, affecting the safety of the product. Inventive content [0003] In order to overcome the deficiencies of the prior art, the present invention provides a method for controlling the preparation of the incenseride sulfide of the traditional Chinese medicine injecting liquid allergic reaction, wh...

Claims

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Application Information

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IPC IPC(8): C07D307/60
CPCC07D307/60
Inventor 刘尧奇郭正友王振蒋春红陈琳方礼刘芳芳简蓝钟仁清魏勇翔
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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