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Percutaneous penetration-promoting drug delivery device

A drug delivery device and microneedle technology, which is applied in the direction of drug devices, hypodermic injection devices, needles, etc., can solve the problems of inability to continuously provide drug physical channels and drug dosage limitations, and achieve the effect of reducing tissue deformation and accelerating penetration

Active Publication Date: 2021-12-28
CENT SOUTH UNIV
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Problems solved by technology

Another example is the publication number CN105816952A, and the name is the invention application of the new electret microneedle transdermal drug delivery system. The microneedle described in this invention is a combination of solid microneedle and soluble microneedle, which cannot continuously provide a physical channel for drug delivery. and doses are limited

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  • Percutaneous penetration-promoting drug delivery device
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  • Percutaneous penetration-promoting drug delivery device

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Embodiment Construction

[0018] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0019] In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Back", "Left", "Right", "Vertical", "Horizontal", "Top", "Bottom", "Inner", "Outer", "Clockwise", "Counterclockwise", "Axial", The orientation or positional relationship indicated by "radial", "circumferential", etc. is based on the orientation or positional relationship shown in the ...

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Abstract

The invention discloses a percutaneous penetration-promoting drug delivery device which comprises a microneedle base, a plurality of microneedles are fixedly arranged on the front face of the microneedle base, an injector and piezoelectric ceramics are fixedly arranged on the back face of the microneedle base, an injection channel communicated with the microneedles and the injector is formed in the microneedle base, and the piezoelectric ceramics are used for driving the microneedles to conduct high-frequency vibration.According to the transdermal permeation-promoting drug delivery device, two permeation-promoting mechanisms of the microneedle and the acoustophoresis are combined, a physical channel from a cuticle layer to a corium layer is continuously provided while a drug is injected, permeation of macromolecular drugs is promoted, high-frequency vibration is generated under external excitation by utilizing the inverse piezoelectric effect of piezoelectric ceramics, ultrasonic waves are emitted. The diffusion speed of the medicine in the skin is effectively increased, and tissue deformation is reduced when the medicine is punctured.

Description

technical field [0001] The invention relates to a transdermal drug delivery device, in particular to a transdermal permeation enhancement drug delivery device. Background technique [0002] Transdermal drug delivery is a method of delivering drugs or biological compounds to the human body. At present, the commonly used drug delivery methods include smear drug delivery, syringe drug delivery, and microneedle drug delivery; compared with traditional subcutaneous injection drug delivery, since the microneedle penetrates the skin at a shallower depth, it cannot touch the nerve tissue in the skin. Therefore, there will be no pain sensation during the administration process. In addition, microneedles generally use needle arrays to microinject drugs, which can achieve uniform distribution of drugs in skin tissue. However, whether it is traditional smear administration, syringe administration, or microneedle administration, the drug concentration decreases from the administration ...

Claims

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Application Information

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IPC IPC(8): A61M37/00
CPCA61M37/0015A61M37/0092A61M2037/0007A61M2037/0023A61M2037/0046A61M2037/0061
Inventor 陈翔陈泽宇彭翰旻陈紫嫣赵爽何志友吴华翼
Owner CENT SOUTH UNIV
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