Preparation process and application of Chinese pulsatilla root granules for livestock and poultry

A preparation process, Pulsatilla Pulsatilla technology, applied to medical preparations containing active ingredients, climate change adaptation, plant raw materials, etc., can solve problems such as high cost of use, inconvenient use, drug delivery conditions, and inconvenient storage and transportation

Pending Publication Date: 2021-12-28
河南纳瑞森生物药业有限公司 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The 2015 edition of "Chinese Veterinary Pharmacopoeia" included "Pulsatilla Oral Liquid", but common Pulsatilla Decoction and Pulsatilla Oral Liquid are widely used in

Method used

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  • Preparation process and application of Chinese pulsatilla root granules for livestock and poultry
  • Preparation process and application of Chinese pulsatilla root granules for livestock and poultry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] It is made of the following medicines: 400g-800g Pulsatillae, 150g-300g Coptidis, 450g-1000g Cortex Phellodendron, 300g-600g Phellodendron Phellodendri; crush the above four ingredients including Pulsatilla Radix, Coptidis Rhizome, Pittia Chinensis, and Phellodendron Phellodendri into small pieces for later use. It is characterized in that it includes the following steps: step (1): above, decocting the above-mentioned 4 flavors with water for 3 times, adding 10 times the amount of water for 1 hour each time, combining the decoction, filtering, and concentrating the filtrate to a relatively Density is 1.20~1.25 (70~80℃); step (2): Add ethanol to the concentrated solution obtained in step (1) to make the alcohol content reach 75%, let it stand for 12 hours, filter the supernatant, add 75% to the residue Appropriate amount of % ethanol, let it stand for 12 hours, filter, combine the ethanol solution, recover the ethanol, adjust the pH value to 5.0, refrigerate for 72 hours,...

Embodiment 2

[0015] It is made from the following medicines: 400g Pulsatillae, 150g Coptidis, 450g Qinpi, and 300g Phellodendron; crush the above four ingredients such as Pulsatilla, Coptidis, Qinpi, and Phellodendron into small pieces, and set aside. According to the steps described in Example 1, the pulsatilla granules for livestock and poultry are obtained, and each g is equivalent to 1.3g of the crude drug. Use continuously for 3 to 5 days. It is suitable for the prevention and treatment of intestinal infectious diseases in the digestive system of livestock and poultry.

Embodiment 3

[0017] Made from the following medicines: 800g Pulsatillae, 300g Coptidis, 1000g Qinpi, 600g Cortex Phellodendron; crush the above four ingredients such as Pulsatillae, Coptidis, Qinpi, and Phellodendron Phellodendri into small pieces for later use. According to the steps described in Example 1, Pulsatilla granules are obtained, and each g is equivalent to 2.7g of the original drug. 5 days. It is suitable for the prevention and treatment of intestinal infectious diseases in the digestive system of livestock and poultry.

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Abstract

The invention relates to a preparation process and an application of Chinese pulsatilla root granules for livestock and poultry. The Chinese pulsatilla root granules are prepared from the following medicines in parts by weight: 400-800g of Chinese pulsatilla root, 150-300g of coptis chinensis, 450-1000g of cortex fraxini and 300-600g of cortex phellodendri, the four traditional Chinese medicines are taken as raw materials, the four traditional Chinese medicines are subjected to crushing, multiple decoction, decoction combination, filtration, alcohol precipitation, ethanol recovery, filtrate concentration and reduced pressure spray drying to obtain extract dry paste, the extract dry paste is crushed at the temperature of below 60 DEG C, and the crushed extract dry paste is subjected to vacuum spray drying to obtain the Chinese pulsatilla root granules. And a proper amount of two or more than two auxiliary materials such as cyclodextrin, starch, superfine silica powder, lactose, glucose and microcrystalline cellulose are added and subjected to uniformly mixing, and granulating by using a low-temperature boiling drying granulator to obtain the Chinese pulsatilla root granules. The Chinese pulsatilla root granules for livestock and poultry have the advantages of high content of effective components, no drug residue and low drug cost, can be used for mixed drinking drug administration in large-scale breeding, are convenient to store and transport, accord with the characteristics of new veterinary drug preparations, and are suitable for preventing and treating intestinal infectious diseases of digestive systems of livestock and poultry.

Description

technical field [0001] The invention relates to a traditional Chinese veterinary medicine preparation capable of preventing and treating intestinal infectious diseases in the digestive system of livestock and poultry and its preparation process and application, especially the preparation process and application of Pulsatilla granules for livestock and poultry. The invention belongs to the field of traditional Chinese medicine preparations. Background technique [0002] Gastrointestinal system infectious diseases are one of the most common diseases affecting the livestock and poultry breeding industry, especially in recent years with the emergence of mixed infections, secondary infections, and drug-resistant bacterial infections, presenting a high incidence rate, complicated disease sources, and difficult control by conventional drugs and other characteristics, bringing serious losses to the breeding industry. Clinically, the digestive system infection of livestock and poultry...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K36/756A61P1/12A61P31/04A61P1/00A61P29/00
CPCA61K9/1652A61K9/1623A61K36/71A61K36/718A61K36/63A61K36/756A61P1/12A61P31/04A61P1/00A61P29/00A61K2236/31A61K2236/39A61K2236/51A61K2236/53A61K2300/00Y02A40/70
Inventor 杨成祥赵云生赵蕾范新蕾司俊伟孟令昭
Owner 河南纳瑞森生物药业有限公司
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