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Vectors and reagent for constructing hNPY and hAgRP gene overexpression chimeric animal model and application

A carrier and reagent technology, applied in the carrier field of animal models, can solve the problems of unfavorable large-scale application, long cycle of animal models, and poor stability of traits, etc., and achieve the effects of short construction cycle, convenient large-scale application, and low cost

Pending Publication Date: 2021-12-24
四川横竖生物科技股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the process of completing the present invention, the inventors found that the method takes a long time to construct an animal model, is greatly affected by individual animals and the environment, and has poor stability of properties, which is not conducive to large-scale application

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  • Vectors and reagent for constructing hNPY and hAgRP gene overexpression chimeric animal model and application
  • Vectors and reagent for constructing hNPY and hAgRP gene overexpression chimeric animal model and application
  • Vectors and reagent for constructing hNPY and hAgRP gene overexpression chimeric animal model and application

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Embodiment Construction

[0053] In order to make it easier for those skilled in the art to further understand the present invention, and to clearly understand the technical solutions described in this application, and to fully and fully disclose the relevant technical content of the present invention, the specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings Description, obviously, the described specific implementation is only an example to give a part of the embodiments of the present invention, to help understand the present invention and its core idea.

[0054] Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative work, and / or without departing from the spirit and essence of the present invention, even if the order of the various steps Changes have been made, and various corresponding changes and deformations have been made according to the pres...

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Abstract

The invention discloses vectors and a reagent for constructing an hNPY and hAgRP gene overexpression chimeric animal model and application. Each vector comprises flag-labeled hNPY and HA-labeled hAgRP lentivirus driven by using Synapsin as a promoter. The reagent comprises a plurality of the vectors. The vectors and the reagent can be used for pathogenesis research of related diseases, screening, verification and test of treatment drug research based on clinical treatment means, preclinical related research and the like. The vectors and the reagent have the characteristics of being short in animal model construction period, high in efficiency, low in cost, high in phenotype extrinsic rate, good in synchronism, high in repeatability, small in difficulty, convenient for large-scale application and the like.

Description

[0001] This application is based on the divisional application of the invention patent application "Construction Method and Application of Chimeric Animal Model Based on Overexpression of hNPY and hAgRP Genes" (Application No. 2019111091115) submitted by the applicant to the State Intellectual Property Office of China on November 13, 2019. technical field [0002] The invention belongs to the field of biotechnology and relates to the construction technology of animal models, in particular to the carrier, reagent and application of the animal model realized in somatic cells by gene technology. Background technique [0003] Animal disease models (animal models) are mainly important tools for research in experimental physiology, experimental pathology and experimental therapeutics (including new drug screening). The development of human diseases is very complicated. Using humans as experimental objects to deeply explore the mechanism of disease occurrence and promote the develop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/867A01K67/027
CPCG01R33/44A61B5/055
Inventor 王正武黄行许赵旭东樊均明唐珂周涛
Owner 四川横竖生物科技股份有限公司
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