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Targeted drug nano system as well as preparation method and application thereof

A drug and nanotechnology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of poor drug targeting, low accuracy, and poor specificity, and achieve the effect of enhancing curative effect, tracking real-time monitoring, and promoting aggregation.

Pending Publication Date: 2021-12-14
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0008] In order to solve the problems of high toxicity, poor specificity, low accuracy and poor targeting of existing drugs in existing MRI contrast agents, the present invention proposes a targeted drug nanosystem and its preparation method and application, using ferric oxide ( Fe 3 o 4 ) as the carrier, with the help of DMSA@Fe 3 o 4 Magnetic nanoparticles are characterized by superparamagnetism, and immunotherapeutic drugs and chemotherapeutic drugs are modified on the surface of nanoparticles by means of surface charge attraction

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  • Targeted drug nano system as well as preparation method and application thereof
  • Targeted drug nano system as well as preparation method and application thereof
  • Targeted drug nano system as well as preparation method and application thereof

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preparation example Construction

[0051] The second aspect of the present invention provides a method for preparing a targeted drug nanosystem, comprising: mixing ferric oxide modified with 2,3-dimercaptosuccinic acid (DMSA) with immunotherapeutic drugs and chemotherapeutic drugs .

[0052] The prior art discloses that some passive targeting carrier drugs need to be taken up into tumor cells through caveolin-mediated endocytosis with the help of liposomes, and the liposomes finally realize the tumor in the form of inducing ferroptosis in tumor cells. purpose of treatment. However, it is impossible to monitor tumors and drugs in real time.

[0053] In some embodiments of the present invention, by using ferric oxide as a carrier, surface-modified immunotherapeutic drugs and chemotherapy drugs can target breast cancer cells, and promote the accumulation of CD4+ cells in tumor sites through combined immunotherapy and chemotherapy. curative effect.

[0054] Experiments have found that if ferric oxide is not modi...

Embodiment 1

[0070] Embodiment 1: FPD (PD-L1@Fe 3 o 4 -DOX) synthesis

[0071] Fe 3 o 4 Synthesis of Nanospheres

[0072] 10.8g FeCl 3 ·6H 2 O and 36.5g sodium oleate were added to a mixed solution of 60mL deionized water, 80mL ethanol and 140mL n-hexane, and the mixed solution was heated and stirred at 70°C for 4h, and the target product, iron oleate, was purified by liquid separation and distillation. Add the obtained ferric oleate into 5.7g oleic acid and 200g octadecene, mix well, heat to 320°C, keep it warm for half an hour, after the reaction, cool to room temperature, add excess ethanol to precipitate Fe 3 o 4 nanoparticles and washed three times with ethanol.

[0073] Fe after washing 3 o 4 Nanospheres react with 2,3-dimercaptosuccinic acid (DMSA) to generate water-dispersible nanomaterials. Dissolve 40 mg DMSA in Na 2 CO 3 In the deionized aqueous solution, add 20mg Fe 3 o 4 Nanoparticles, then add 1mL tetrahydrofuran, react under ultrasonic conditions for half an h...

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Abstract

The invention relates to the technical field of carrier drugs, in particular to a targeted drug nano system as well as a preparation method and application thereof. In order to solve the problems that an existing MRI contrast agent is large in toxicity, poor in specificity and low in accuracy and an existing drug is poor in targeting performance, the targeted drug nano system and the preparation method and application of the targeted drug nano system are provided, ferroferric oxide (Fe3O4) serves as a carrier, and by means of the superparamagnetism characteristic of DMSA@Fe3O4 magnetic nano particles, immunotherapeutic drugs and chemotherapeutic drugs are modified on the surfaces of the nanoparticles in a surface charge attraction mode. The targeted drug nano system can promote CD4 + cells to gather at a tumor site through combined treatment of immunization and chemotherapy, the curative effect is enhanced in a mutual promotion mode, in addition, real-time tracking of drugs and real-time monitoring of the curative effect can be achieved by means of MRI, and the effect of integration of diagnosis and treatment is achieved.

Description

technical field [0001] The invention relates to the technical field of carrier drugs, in particular to a targeted drug nano system and its preparation method and application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Breast cancer is the most common malignant tumor in women and the second leading cause of cancer-related death in women. Among them, triple-negative breast cancer (TNBC) has high tumor grade and advanced disease stage, accounting for 10% of all invasive breast cancers. % to 20%, the treatment is particularly difficult. [0004] At present, the diagnosis of breast cancer mainly relies on pathological biopsy and imaging diagnosis. Although the former is...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/68A61K49/18A61K49/16A61K39/395A61K31/136A61K31/337A61K31/704A61P35/00B82Y5/00B82Y15/00B82Y40/00
CPCA61K47/6923A61K47/6855A61P35/00A61K49/1824B82Y5/00B82Y15/00B82Y40/00A61K49/16A61K39/3955A61K31/704A61K31/136A61K31/337A61K2039/505A61K2300/00
Inventor 于德新赵洁李明
Owner SHANDONG UNIV QILU HOSPITAL
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