Influenza new coronary combined vaccine and preparation method thereof
A combined vaccine and influenza technology, applied in biochemical equipment and methods, vaccines, multivalent vaccines, etc., to achieve good compatibility, high safety, and high cost-effectiveness.
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Embodiment 1
[0039] Influenza-COVID-19 combined vaccine, including raw materials with the following mass concentrations: recombinant COVID-19 vaccine containing RBD-Fc fusion protein, with a mass concentration of 80 μg / mL; influenza subunit vaccine containing H1N1 influenza virus, with a mass concentration of 18 μg / mL; containing H3N2 Influenza subunit vaccine of type B influenza virus, the mass concentration is 18μg / mL; Influenza virus subunit vaccine containing type B influenza virus, the mass concentration of influenza virus subunit vaccine is 18μg / mL; aluminum hydroxide solution, aluminum ion in the combination of influenza and new crown The final concentration in the vaccine is 0.6 mg / mL; the balance is PBS phosphate buffer.
[0040] The preparation method of the above-mentioned influenza and new crown combined vaccine specifically comprises the following steps:
[0041] (1) Weigh each raw material according to the mass fraction of the above-mentioned combined influenza and COVID-19 vac...
Embodiment 2
[0054] Influenza-COVID-19 combined vaccine, including raw materials with the following mass concentrations: recombinant COVID-19 vaccine containing RBD-Fc fusion protein, with a mass concentration of 5 μg / mL; influenza subunit vaccine containing H1N1 influenza virus, with a mass concentration of 20 μg / mL; containing H3N2 Influenza subunit vaccine of Type B influenza virus, mass concentration is 20 μg / mL; Influenza virus subunit vaccine containing influenza virus type B, mass concentration is 20 μg / mL; Aluminum hydroxide solution, the final concentration of aluminum ion is 0.6mg / mL; the balance is PBS phosphate buffer.
[0055] The preparation method of the above-mentioned influenza and new crown combined vaccine specifically comprises the following steps:
[0056] (1) Weigh each raw material according to the mass fraction of the above-mentioned combined influenza and COVID-19 vaccine;
[0057] Wherein, the preparation method of aluminum hydroxide solution is:
[0058] ① Weig...
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