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A polydopamine@gold composite nanoflower drug-loaded particle and its preparation method and application

A polydopamine and nanoflower technology, which is applied in the fields of biomedical materials and nanomedicine, can solve the problems of poor photothermal effect of gold nanoparticles, complicated preparation and poor stability, and achieves good application prospects, simple preparation and good stability. Effect

Active Publication Date: 2022-04-19
HAINAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, gold nanoparticles have the problems of poor photothermal effect, poor stability and complicated preparation.

Method used

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  • A polydopamine@gold composite nanoflower drug-loaded particle and its preparation method and application
  • A polydopamine@gold composite nanoflower drug-loaded particle and its preparation method and application
  • A polydopamine@gold composite nanoflower drug-loaded particle and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation method of polydopamine@gold composite nanoflower drug-loaded particles:

[0035] This example is used to illustrate that the in situ formation template of the composite nanoflower drug-loaded particles can not only use PLGA fiber scaffolds, but also other three-dimensional porous scaffolds with good biocompatibility, low cost and environmental protection. For example, polydopamine@gold composite nanoflower drug-loaded particles (PDA@AuNFs) were synthesized on bacterial cellulose membrane.

[0036] Prepare 150mL Tris-HCl buffer solution with a pH of 8.5, add 0.15-0.18g of dopamine hydrochloride, add bacterial cellulose membrane and stir for 24 hours, self-polymerize on the surface of bacterial cellulose membrane to form polydopamine particles, extract the polydopamine particles on the surface of the film and add chlorine Auric acid solution, with a final mass concentration of 0.01%, left to react at room temperature for 9 hours to aggregate composite gold nan...

Embodiment 2

[0038] Preparation method of polydopamine@gold composite nanoflower drug-loaded particles:

[0039] Configure 150mL of Tris-HCl buffer solution with a pH of 8.5, the mass percentage of dopamine hydrochloride and bacterial cellulose membrane is 1:21, the stirring reaction time at room temperature is 22h, the volume concentration of hydrochloric acid is 0.1mol / L, the dopamine hydrochloride solution The volume concentration is 1mg / mL, polydopamine particles are self-polymerized on the surface of the bacterial cellulose membrane, and the polydopamine particles on the surface of the film are extracted and added to the chloroauric acid solution to make the final mass concentration 0.01%, and the reaction is allowed to stand at room temperature for 9 hours to aggregate and composite gold nanoparticles. Particles, the centrifugation speed is 3000rpm, and the centrifugation time is 20min to collect and obtain PDA@AuNFs, and store them at a temperature of 4°C; and the size of the composi...

Embodiment 3

[0041] Preparation method of polydopamine@gold composite nanoflower drug-loaded particles:

[0042] Configure 150mL of Tris-HCl buffer solution with a pH of 8.5, the mass percentage of dopamine hydrochloride and bacterial cellulose membrane is 1:25, the stirring reaction time at room temperature is 22h, the volume concentration of hydrochloric acid is 1mol / L, the volume of the dopamine hydrochloride solution The concentration is 1.2 mg / mL, polydopamine particles are self-polymerized on the surface of the bacterial cellulose membrane, and the polydopamine particles on the surface of the film are extracted and added to the chloroauric acid solution to make the final mass concentration 0.015%, and the reaction at room temperature is allowed to stand for 9 hours. Particles, the centrifugation speed is 4500r / min, and the centrifugation time is 30min to collect and obtain PDA@AuNFs, and store them at a temperature of 4°C; and the size of the composite nanoflower drug-loaded particles...

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Abstract

The invention belongs to the fields of biomedical materials and nanomedicine, and specifically discloses a polydopamine@gold composite nano-flower drug-loaded particle, a preparation method and application thereof. In the present invention, the technology of preparing PDA@Au composite nanoflower particles by using polydopamine nanoparticles as reaction binding sites in patterned aggregation has the advantages of simple preparation, low price, good dispersibility, good stability, and multifunctionality; at the same time, PDA @Au composite nanoflower particles can be grafted with functional drugs, endowing the flower-like composite nanoparticle drug-loading system with photothermal response and drug-controlled release characteristics, which can achieve the purpose of photothermal-chemotherapy combination therapy, and has good application in combination therapy prospect.

Description

technical field [0001] The invention belongs to the fields of biomedical materials and nanomedicine, and relates to a preparation method of polydopamine@gold composite nanoflower drug-loaded particles. Background technique [0002] Bacterial infection is one of the main reasons threatening human health, but the abuse of traditional antibiotics has led to the emergence of super-resistant bacteria. Bacterial drug resistance will lead to high morbidity and mortality, so there is an urgent need for new and effective antibacterial agents against infections caused by super-resistant bacteria. [0003] In recent years, the preparation and antibacterial activity of nanomaterials have attracted widespread attention. The research on metal nanoparticles, especially the preparation of their shape-controllable properties and their application, has always been a hot topic in materials science and related fields. Nanoparticles such as silver, copper, iron oxide, zinc oxide, etc. have anti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/34A61K41/00A61K47/59A61K47/69A61K45/06A61P31/04B82Y5/00B82Y40/00
CPCA61K9/5146A61K9/5192A61K41/0052A61K47/59A61K47/6935A61K45/06A61P31/04B82Y5/00B82Y40/00A61K2300/00
Inventor 李萌婷洪季璇尹学琼秦梓喻李昌贵曹夏馨张畅泽
Owner HAINAN UNIV
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