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Cream for treating herpes zoster and preparation method of cream

A herpes zoster and formula technology, applied in the field of medicine, can solve problems such as being unsuitable for clinical promotion and application, unclear preparation method, inaccurate curative effect, etc., and achieve the effects of no adverse reactions and sequelae, no toxic side effects, and significant therapeutic effects.

Active Publication Date: 2021-11-12
广西馨海药业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Patent CN103479820A discloses a Chinese patent medicine for treating herpes zoster, which contains 8 kinds of medicinal flavors such as Pulsatilla zoster. It has many medicinal flavors, high cost, unclear preparation method, and uncertain curative effect, so it is not suitable for clinical application.

Method used

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  • Cream for treating herpes zoster and preparation method of cream
  • Cream for treating herpes zoster and preparation method of cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 composition of the present invention

[0025] (1) Pulsatilla extract extract: Pulsatilla medicinal material is reflux extracted 3 times with 70% ethanol with 8 times of v / w, ml / g, each time for 2 hours, the combined extracts are filtered, and the filtrate is concentrated to 60°C with a relative density of 1.05- 1.10, the filtrate was dissolved in water, passed through AB-8 resin, eluted with 50% ethanol, and the eluate was concentrated under reduced pressure to a thick paste with a relative density of 1.20 at 60°C.

[0026] (2) Oil phase: 8g of stearic acid, 4g of vaseline, 1g of lanolin, 8g of glyceryl monostearate, heated to 80°C to melt into an oil phase, stirred until uniform, and kept warm for later use.

[0027] (3) Water phase: 8 g of glycerin, 4 g of triethanolamine, and 0.1 g of ethylparaben, heated to 80° C. to dissolve into water phase, stirred until uniform, and set aside for later use.

[0028] (4) Under stirring, slowly add...

Embodiment 2

[0029] The preparation of embodiment 2 compositions of the present invention

[0030] (1) Pulsatilla extract extract: Pulsatilla medicinal material is extracted 3 times with 10 times the amount of 70% ethanol under reflux, each time for 2 hours, the combined extracts are filtered, the filtrate is concentrated to 60 °C relative density 1.05-1.10, the filtrate is dissolved in water and filtered AB-8 resin was eluted with 50% ethanol, and the eluate was concentrated under reduced pressure to a thick paste with a relative density of 1.20 at 60°C.

[0031] (2) Oil phase: stearic acid 10g, vaseline 5g, lanolin 2g, glyceryl monostearate 9g, heated to 80°C to melt into an oil phase, stirred until uniform, kept warm for later use.

[0032] (3) Water phase: 10 g of glycerin, 6 g of triethanolamine, and 0.2 g of ethylparaben were heated to 80° C. to dissolve into the water phase, stirred until uniform, and set aside for later use.

[0033] (4) Under stirring, slowly add the water phase ...

Embodiment 3

[0034] The preparation of embodiment 3 compositions of the present invention

[0035] (1) Pulsatillae extract extract: Pulsatilla medicinal material is extracted 3 times with 12 times the amount of 70% ethanol under reflux, each time for 2 hours, the combined extracts are filtered, and the filtrate is concentrated to a relative density of 1.05-1.10 at 60°C. The filtrate is dissolved in water and filtered. AB-8 resin was eluted with 50% ethanol, and the eluate was concentrated under reduced pressure to a thick paste with a relative density of 1.20 at 60°C.

[0036] (2) Oil phase: 12g of stearic acid, 6g of vaseline, 3g of lanolin, 10g of glyceryl monostearate, heated to 80°C to melt into an oil phase, stirred until uniform, kept warm for later use.

[0037] (3) Water phase: 12 g of glycerin, 8 g of triethanolamine, and 0.3 g of ethylparaben were heated to 80° C. to dissolve into the water phase, stirred until uniform, and set aside for later use.

[0038] (4) Under stirring, s...

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Abstract

The invention discloses an application of pulsatilla chinensis or an extract thereof to preparation of a medicine for treating herpes zoster, and a composition taking the pulsatilla chinensis extract as an active component. The composition has no toxic or side effect on human bodies, has no adverse reaction or sequelae after being used by patients, has the effect of treating herpes zoster remarkably superior to that of acyclovir cream commonly used in clinic at present, is an externally-applied good medicine for treating skin herpes zoster, and is worthy of popularization and application. The damage to the gastrointestinal function of a human body caused by oral medicines is avoided; besides, a remarkable treatment effect is achieved; and the cream has wide application value.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a cream for treating herpes zoster and a preparation method thereof. Background technique [0002] Herpes zoster is a common acute mucocutaneous disease caused by varicella-zoster virus (VZV). After most patients are infected with varicella-zoster virus, flushing spots first appear, and then develop into miliary to soybean-sized papules, which are distributed in clusters without fusion, and then quickly turn into blisters, the walls of which are tense and shiny, and the blister fluid is clear , surrounded by blush, accompanied by symptoms such as fever, fatigue and anorexia; the course of the disease is 2-3 weeks, there is no recurrence after the disease, and lifelong immunity can be obtained. After being infected, some patients become carriers of the virus without symptoms. Because the virus is neurotropic, it can remain latent in the neurons of the spinal nerve and heel gan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/06A61K9/08A61K9/70A61P31/22
CPCA61K36/71A61K9/06A61K9/08A61K9/7007A61K9/0014A61K47/44A61P31/22A61K2236/333A61K2236/51A61K2236/55Y02A50/30
Inventor 杨世林苏柘僮
Owner 广西馨海药业科技有限公司
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