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Application of supramolecular organic framework material to medicine for removing photodynamic therapy residues

A photodynamic therapy and organic framework technology, applied in the field of biomedicine, to achieve the effect of reducing photosensitivity and reducing the cumulative amount

Pending Publication Date: 2021-11-09
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, patients after photodynamic therapy have to be kept in the dark before the photosensitizer is excreted (≥ 30 days), which brings great inconvenience and psychological pressure to the patients

Method used

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  • Application of supramolecular organic framework material to medicine for removing photodynamic therapy residues
  • Application of supramolecular organic framework material to medicine for removing photodynamic therapy residues
  • Application of supramolecular organic framework material to medicine for removing photodynamic therapy residues

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1: Preparation of supramolecular organic framework material SOFs.

[0069] References for the preparation method of the water-soluble positive ion supramolecular organic framework material provided by the invention Nat. Commun. 2014, 5 : 5574.

Embodiment 2

[0070] Example 2: Characterization of SOFs and photodynamic therapy drugs in aqueous solution.

[0071] Prepare photosensitizer solutions with different concentrations, use tetrahedron monomer concentration as standard, add SOFs solution dropwise, and perform fluorescence test. With the addition of SOFs, the fluorescence intensity of the photosensitizer decreased continuously until the equilibrium. Such as Figure 1~Figure 12 As shown, the good interaction between SOFs and photosensitizers can be confirmed by fluorescence test. Such as Figure 13~Figure 24 As shown, the DLS test can confirm that the SOFs can exist stably after absorbing the photosensitizer, and the particle size does not change much. Such as Figure 25~Figure 26 As shown, the dialysis experiment shows that SOFs can effectively absorb the photosensitizer and prevent the photosensitizer from being leaked out.

Embodiment 3

[0072] Example 3: Research on the inhibition of SOFs on the photosensitization reaction of photosensitizers.

[0073] At the animal level, we investigated the inhibition of photosensitization by photosensitizers by SOFs. Taking porfimer sodium (Phorofrin) as a photosensitizer as an example, firstly inject the photosensitizer into the tail vein, and then inject SOFs into the tail vein after a period of time, and light the skin on the back of the animal after feeding in the dark room for different times, observe the skin reaction of the animal, and take pictures. Take the skin and make slices. Such as Figure 27 and Figure 28 As shown, the results of skin photosensitization showed that the animals in the photosensitizer group had severe photosensitivity reactions, and obvious redness and erythema appeared on the skin, and the skin photosensitivity reactions of animals injected with SOFs were significantly inhibited. Such as Figure 29 As shown, the skin weight results in th...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to an application of a supramolecular organic framework material to a medicine for removing photodynamic therapy residues. The supramolecular organic framework material is a nano-particle-size water-soluble positive ion type supramolecular organic framework material (SOFs) which is formed by tetrahedral molecules and CB [8] in a water phase through host-guest interaction, and the supramolecular organic framework material realizes high-strength combination and efficient absorption on negatively charged photodynamic therapy medicines (such as chlorin (Ce6), hematoporphyrin (HMTP) and porfimer sodium (Photofrin)). Animal experiments prove that the supramolecular organic framework material can significantly reduce the cumulant of the photodynamic therapy medicine on the surface of animal skin, effectively inhibit the photosensitization of the photodynamic therapy medicine after being irradiated by sunlight, and solve the problem that a patient needs to keep out of light for a long time after photodynamic therapy to a certain extent.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of a supramolecular organic framework material in removing residual drugs in photodynamic therapy and inhibiting its photosensitization. Background technique [0002] Cancer is considered to be the leading cause of death in humans and an important obstacle to prolonging life. In 2020, there will be approximately 19.3 million new cancer cases and 10 million cancer deaths worldwide. It is estimated that there will be 28.4 million new cancer cases worldwide in 2040, an increase of 47% over 2020. Traditional cancer treatments, such as radiotherapy and chemotherapy, can damage normal organ functions and cause serious side effects. In contrast, Photodynamic Therapy (PDT), as a non-invasive cancer treatment, has the advantages of high anticancer efficiency, broad spectrum, no drug resistance, high selectivity and controllability. It has broad application...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K41/00A61P35/00C08G83/00
CPCC08G83/008A61K47/6949A61K41/0071A61K9/0019A61P35/00
Inventor 黎占亭张丹维刘亚敏刘传志马达周伟王辉
Owner FUDAN UNIV
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