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Three-dimensional liquid in-situ SERS detection substrate and preparation method and application thereof

A liquid, in-situ technology, applied in the field of SERS substrates, can solve problems such as poor repeatability, low sensitivity of detection signals, and difficulty in sufficient contact, and achieve the effects of high repetition rate, enhanced interaction, and enhanced sensitivity

Pending Publication Date: 2021-11-02
ZHONGBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The invention prepares a multi-level dendritic gold-silver composite SERS detection substrate embedded in a capillary glass tube, and is successfully applied to the field of liquid in-situ real-time detection, which solves the problem that the current SERS substrate is difficult to fully contact with the flowing liquid, and the detection signal Problems such as low sensitivity and poor repeatability

Method used

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  • Three-dimensional liquid in-situ SERS detection substrate and preparation method and application thereof
  • Three-dimensional liquid in-situ SERS detection substrate and preparation method and application thereof
  • Three-dimensional liquid in-situ SERS detection substrate and preparation method and application thereof

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Embodiment 1

[0030] A three-dimensional liquid in-situ SERS detection substrate. In a channel tube encapsulated with a metal wire, a dendritic gold-silver composite multi-level structure that runs through the metal wire and the channel tube is prepared through a displacement reaction to form a three-dimensional liquid in-situ SERS detection. base.

[0031] A method for preparing the above-mentioned three-dimensional liquid in-situ SERS detection substrate, comprising the following steps:

[0032] Step 1, pretreat the capillary glass tube: place the capillary glass tube in piranha solution, soak it for 12 hours, wash it with ultrapure water, and dry it at room temperature for later use;

[0033] Step 2, place the wire in ethanol for ultrasonic cleaning for 10 minutes, and then wash it with ultrapure water, as figure 1 As shown, insert into the capillary glass tube, both ends of the capillary glass tube are sealed, and only the liquid flow channel is left. The inherent electrochemical pote...

Embodiment 2

[0043]A method for preparing a three-dimensional liquid in-situ SERS detection substrate, the specific steps are as follows:

[0044] At room temperature, dissolve 0.85g of silver nitrate powder and 0.1g of chloroauric acid in 50mL of ultrapure water, stir magnetically at 2000rpm for 5min, and prepare a silver nitrate solution with a concentration of 0.1mol / L and 0.005mol / L of chloroauric acid. Solution, keep away from light for later use. Three pure copper wires with a length of 50 mm and a diameter of 0.05 mm were ultrasonically cleaned and dried for later use. Set up the reaction channel, inject the silver nitrate solution, set the flow rate of the syringe pump to 0.2mL / min, and react for 15min. Subsequently, the chloroauric acid solution was continuously injected through the syringe pump, the flow rate of the syringe pump was 0.1 mL / min, and the reaction time was 30 min. After the reaction, adjust the speed of the syringe pump to 2 mL / min, inject 30 mL of ultrapure water...

Embodiment 3

[0046] A method for preparing a three-dimensional liquid in-situ SERS detection substrate, the specific steps are as follows:

[0047] At room temperature, dissolve 0.85g of silver nitrate powder and 0.1g of chloroauric acid in 50mL of ultrapure water, stir magnetically at 2000rpm for 5min, and prepare a silver nitrate solution with a concentration of 0.1mol / L and 0.005mol / L of chloroauric acid. Solution, keep away from light for later use. Five pure copper wires with a length of 50 mm and a diameter of 0.05 mm were ultrasonically cleaned, and dried for later use. Set up the reaction channel, inject the silver nitrate solution, set the flow rate of the syringe pump to 0.2mL / min, and react for 15min. Subsequently, the chloroauric acid solution was continuously injected through the syringe pump, the flow rate of the syringe pump was 0.1 mL / min, and the reaction time was 30 min. After the reaction, adjust the speed of the syringe pump to 2 mL / min, inject 30 mL of ultrapure wate...

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Abstract

The invention relates to an SERS (Surface Enhanced Raman Scattering) substrate with a surface-enhanced Raman scattering effect, in particular to a three-dimensional liquid in-situ SERS detection substrate as well as a preparation method and application thereof. Silver and gold salt solutions are sequentially introduced into a channel tube packaged with a metal wire, a dendritic gold-silver composite multilevel structure penetrating through the metal wire and the channel tube is prepared through a replacement reaction, the three-dimensional liquid in-situ SERS detection substrate is formed, and the problems that an existing SERS substrate is difficult to make full contact with flowing liquid, detection signal sensitivity is low, repeatability is poor and the like are solved. The SERS substrate is embedded in the channel pipe, and liquid to be detected flows through the channel pipe, so that in-situ real-time detection of the detected liquid is realized.

Description

technical field [0001] The invention relates to a SERS substrate with a surface-enhanced Raman scattering effect, in particular to a three-dimensional liquid in-situ SERS detection substrate and a preparation method and application thereof. Background technique [0002] As a powerful and effective spectral analysis technique, surface-enhanced Raman scattering spectroscopy (SERS) has the advantages of fingerprint identification, high sensitivity, fast and non-destructive, and has great potential application value in the fields of medicine, environment, food safety, and catalysis. However, due to the diffusion characteristics of the analyte, the Raman detection of liquid media depends on the degree of binding of the analyte to the hotspot area, which limits the practical application of Raman spectroscopy in the detection of trace elements to a certain extent. [0003] At present, a large number of literatures have reported the application of SERS technology in the field of env...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 梅林玉邵云鹏郝耀武李莎王泽洲
Owner ZHONGBEI UNIV
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