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Application of ferulic acid in treatment of radioactive skin injury

A radiation-induced skin and radiation-injured technology, applied in the application field of ferulic acid in the treatment of radiation-induced skin injuries, to achieve the effects of obvious wound granulation tissue hyperplasia, reduced skin edema, and good damage repair effect

Pending Publication Date: 2021-10-29
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ferulic acid has a wide range of effects, so far, there is no invention of ferulic acid or a gel made of ferulic acid that can be used to treat radiation-induced skin damage

Method used

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  • Application of ferulic acid in treatment of radioactive skin injury
  • Application of ferulic acid in treatment of radioactive skin injury
  • Application of ferulic acid in treatment of radioactive skin injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] This example introduces a kind of preparation method of ferulic acid gel, specifically comprises the following contents:

[0057] The preparation method of ferulic acid gel is as follows: disperse 0.75g carbomer in 75ml, 80ml, 85ml distilled water and fully swell for 24h; add 5g glycerol and 0.001g p-hydroxyl to the fully swollen carbomer with different concentrations Ethyl benzoate, after mixing with a stirring rod, add 5g, 10g, 15g ferulic acid and mix respectively; final quantification, add an appropriate amount of triethanolamine in the gel to adjust the pH value and viscosity, and quantify to 100g to obtain three different concentrations of ferulic acid gel.

Embodiment 2

[0059] This example illustrates the effects of different concentrations of ferulic acid solutions on the viability of HaCaT cells.

[0060] In this example, HaCaT cells were treated with different concentrations of ferulic acid (300, 200, 100, 50, 25 μg / ml), and the cell viability of HaCaT cells was detected 24 hours after administration. After ferulic acid was administered to HaCaT cells in good condition for 24 hours, compared with the control group without administration, ferulic acid at each concentration had no significant change on the viability of normal HaCaT cells. Figure 1A Shown: Figure 1A is the effect of different concentrations of ferulic acid solution on the viability of normal HaCaT cells; with 60 HaCaT cells were irradiated with Coγ-rays to form a cell model of radiation skin injury. Vitamin C was used as a positive control drug, and different concentrations of ferulic acid (200, 100, 50, 25 μg / ml) were used to treat the irradiated HaCaT cells. Effects of co...

Embodiment 3

[0068] In this example, different concentrations of ferulic acid are 60 The changes of ROS in HaCaT cells after Coγ-ray irradiation are described.

[0069] when 60 After Coγ-rays irradiate the skin, ROS will be induced, and when the redox balance of the skin is broken, it will cause oxidative damage to the skin. Give an absorbed dose of 18Gy 60 HaCaT cells were stimulated by Coγ-rays, and VC and ferulic acid were given to intervene before irradiation. The irradiated HaCaT cells were treated with different concentrations of ferulic acid (200, 100, 50, 25 μg / ml), and the effects of different concentrations of ferulic acid on the ROS level of HaCaT cells were detected 24 hours after irradiation.

[0070] like figure 2 as shown, figure 2 For different concentrations of ferulic acid 60 Changes of ROS in HaCaT cells after Coγ-ray irradiation ( n=3), ### P<0.001 compared with normal group, *P<0.05, **P<0.01vs, ***P<0.001 compared with irradiation group.

[0071] Compare...

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Abstract

The invention relates to a novel application of ferulic acid in treatment of radioactive skin injury, ferulic acid is prepared into a gel form, and the product has a good protection effect on cells and animal models damaged by <60> Co-gamma rays, has no stimulation effect on normal skin and can significantly enhance the oxidation resistance of HaCaT cells damaged by radiation. The ferulic acid gel is stable in physicochemical property, after the ferulic acid gel is used, the occurrence time of a skin wound is delayed, the red and swollen skin wound and the damaged area are reduced, and the skin blood flow at the wound is reduced than that of a non-medication group. The ferulic acid gel can inhibit activation of NLRP3 inflammasomes and reduce generation of inflammatory factors IL-18 and IL-1beta, so that inflammation is promoted to be relieved, injury edema is relieved, a good injury repairing effect on radioactive skin injury is achieved, and the technical effect of radiation resistance is achieved.

Description

technical field [0001] The invention relates to the field of medicine application, in particular to the application of ferulic acid in treating radiation skin damage. Background technique [0002] Radiation skin damage refers to the skin damage caused by the whole body or part of the body being exposed to a certain dose of radiation. It is often seen in radiotherapy, nuclear leaks, and nuclear safety accidents. It has the characteristics of latent, persistent, repetitive, and difficult to heal. . Radiation therapy is a routine treatment for tumors in clinical practice, but about 90% of patients will experience adverse reactions of radiation skin damage, but the common side effects of skin damage limit its wider application, and also affect the quality of life and treatment of patients. It has brought adverse effects, so it is of great significance to develop drugs for the prevention and treatment of radiation-induced skin damage. [0003] Radiation skin injury is divided i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K9/06A61K47/32A61P17/16A61P29/00A61P17/00
CPCA61K31/192A61K9/06A61K9/0014A61K47/32A61P17/16A61P29/00A61P17/00
Inventor 高月马增春黄从书王宇光汤响林肖成荣周维郝斐然
Owner ACADEMY OF MILITARY MEDICAL SCI
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