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Composite marker for diagnosis of age related macular degeneration and use thereof

A biomarker, macular degeneration technology, applied in the field of composite biomarkers, can solve problems such as reducing central vision, damage to photoreceptor cells, bleeding, etc., and achieve the effect of high diagnostic ability

Pending Publication Date: 2021-10-22
RETI MARK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These new blood vessels can cause macular exudate and hemorrhage, etc., damage the photoreceptor cells, thereby reducing central vision, and if untreated, most lead to legal blindness under 0.1

Method used

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  • Composite marker for diagnosis of age related macular degeneration and use thereof
  • Composite marker for diagnosis of age related macular degeneration and use thereof
  • Composite marker for diagnosis of age related macular degeneration and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Example 1: Choosing age-related macular degenerative patients and collecting plasma

[0102] The approval of the clinical trial review committee of the Pot Tangjrew University Hospital was obtained to collect the plasma samples of age-relevance macular transition patients. For the quantitative detection of biomarkers, a total of 184 plasma samples were analyzed by plasma proteomics. Table 1 shows the normal group (NON AMD) and age-related macular degenerative (AMD) disease groups as analytical objects. Clinical features.

[0103] Table 1

[0104] Sample clinical information

[0105]

Embodiment 2

[0106] Example 2: Select peptide and use multi-reaction monitoring mass spectrometry quantitative analysis peptide

[0107] 2-1: Select peptide and design synthetic peptide

[0108] In the present invention, as a biomarker for diagnosing age-related macular degeneration, 13 of the following: IGFBP2 (insulin-like growth factor binding protein 2), Ada MTSL2 (ADAMTS sample protein 2), CFH (supplementary factor) H), CP (Copper Blue Protein), DDI2 (Protein DDI1 Source 2), Fcn2 (Fibrin Glue 2), LGALS3B P (galactin 3 binding protein), MBL2 (mannose binding protein C), pnlip (Pancreatal trioin fat enzyme), SELE (E-selectin), Siglec14 (sialic acid binding immunoglobulin-like concentrate 14), THBS1 (platelet-free protein-1) and ZG16B (enzyme original particulate protein 16 homolog) B).

[0109] In order to perform multi-reaction monitoring analysis of the above biomarkers, representative peptides (Q1) having a talloid ratio (M / Z) for the protein specificity of 13 biomarkers were selecte...

Embodiment 3

[0122] Example 3: Confirmation of the improvement of the diagnostic ability of the composite biomarker group and clinical information

[0123] In the present invention, when combined with 13 composite biomarker groups and clinical information, in order to confirm the improvement of the diagnostic ability, the degree of input biomarker expression quantity conversion information and clinical information conversion is used, thereby speculating classification The probability of age-related macular degeneration.

[0124] table 3

[0125] Confirm that the age-related macular degenerative diagnosis performance according to the composite biomarker binding

[0126]

[0127] 1. Clinical information, 2.IGFBP2, 3.adamtsl2,4.lgals3bp, 5.cfh, 6.thbs1 ,7.siglec14, 8.cp, 9.SELE, 10.DDI2, 11.M BL2, 12.PNLIP, 13.ZG16b, 14.fcn2

[0128] Table 4

[0129] Confirmation according to the diagnostic ability of the composite biomarker group and clinical information

[0130]

[0131] C: Clinical informat...

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Abstract

The present invention relates to a composite marker for diagnosis of age related macular degeneration (AMD) and a use of same and, more specifically, to a composite markers for diagnosis of age related macular degeneration, which consists of two or more blood markers specific to diagnosis of age related macular degeneration and has improved diagnostic performance. In addition, the present invention relates to a composition for diagnosis of age related macular degeneration, a diagnostic kit, and a method for providing information necessary for diagnosing age related macular degeneration, each of which uses the composite marker. The composite marker for diagnosis of age related macular degeneration of the present invention was found to be superior to combinations of other markers in terms of sensitivity and diagnosis performance and to exhibit a high diagnostic potential for both initial and late macular degeneration, as analyzed for combinations between protein quantitation values of the composite marker and fundamental clinical information. In addition, the composite marker of the present invention does not use blood proteins for biopsy, but can conveniently perform analysis using patient plasma and as such, can be advantageously applied to the early diagnosis of age related macular degeneration.

Description

Technical field [0001] The present invention relates to a composite biomarker for diagnosing age-associated macular degeneration (AMD) and its use, in more detail, involving two or more blood biological marks specific to age-related macular degeneration Composite biomarkers for diagnostic relevance macular degenerations for diagnosis performance. Further, the present invention relates to the information providing method for diagnosing age-related macular degenerative compositions, diagnostic kits, and diagnostic age-related macular degeneration using the composite biomarkers. Background technique [0002] Age-relevance macular degeneration is a disease caused by a variety of changes in the center of retinals in adults over the age of 50, and is one of the three major blind diseases in the eye. . In developed countries, it is the main reason why adult blindness, increasing the incidence increases with age. According to South Korea's national healthy nutrition survey, in the preval...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883G01N33/68G01N33/573
CPCC12Q1/6883G01N33/6893G01N33/573C12Q2600/158G01N2800/164G01N2800/60G01N2800/16C12Q2600/156
Inventor 朴晟濬李泳珠金惠林
Owner RETI MARK CO LTD
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