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Application of dithiobibutyl phenol and analogue in prevention and treatment of organ injury diseases caused by coronavirus pneumonia (including COVID-19)

A kind of coronavirus, the technology of use, applied in the field of medicine, can solve the problems of cell damage, membrane fluidity change, membrane function loss, etc., and achieve the effect of eliminating symptoms, changing high passability, and inhibiting serious damage to organs

Pending Publication Date: 2021-10-12
北京中美红格科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Since an important target of free radicals acting on tissues is biological membranes, free radicals not cleared by defense mechanisms can induce lipid peroxidation of membranes, resulting in loss of membrane function, inactivation of enzymes, and loss of membrane fluidity. changes, resulting in cell damage

Method used

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  • Application of dithiobibutyl phenol and analogue in prevention and treatment of organ injury diseases caused by coronavirus pneumonia (including COVID-19)
  • Application of dithiobibutyl phenol and analogue in prevention and treatment of organ injury diseases caused by coronavirus pneumonia (including COVID-19)
  • Application of dithiobibutyl phenol and analogue in prevention and treatment of organ injury diseases caused by coronavirus pneumonia (including COVID-19)

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1. The activity test of compound of the present invention to SOD

[0046] Experimental principle and model establishment:

[0047] Doxorubicin can induce excessive production of reactive oxygen species (ROS), and is closely related to the increase of cellular oxidative stress. The compound of the present invention is tested and found that the compound of the present invention can alleviate the effect of doxorubicin on intracellular GSH-Px ( Glutathione peroxidase-) and the inhibition of SOD activity are also accompanied by the reduction of ROS and lipid peroxidation product MDA induced by doxorubicin. These results suggest that the compound of the present invention is especially 4,4'-( Methylenedisulfide)bis(2,6-di-tert-butylphenol) showed activity on superoxide dismutase bioenzyme activity-inducing target It has higher specificity and human endogenous peptide chains, protein rearrangement and aggregation.

Embodiment 2

[0048] Embodiment 2. The in vivo pharmacokinetic test of compound of the present invention

[0049] Experimental results show that the compound of the invention has good pharmacokinetic properties and is suitable for making medicines.

Embodiment 3

[0050] Example 3. Activity test of compounds of the present invention for in vivo cell damage

[0051] Cell injury model: The pathological model is established by causing cell injury in animals in vivo by the chemotherapeutic drug doxorubicin.

[0052] The experimental results shown in Table 1 below show that the compound of the present invention can effectively protect against cell damage, wherein the compound is selected from 4,4'-(methylene disulfide)bis(2,6-di-tert-butylphenol).

[0053] Table 1

[0054]

[0055]

[0056] Table 1 - continued a

[0057]

[0058]

[0059] Table 1 - continued b

[0060]

[0061]

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Abstract

The invention provides an application of a dithiobibutyl phenol compound and an analogue in preparation of a medicine for preventing and / or treating injury diseases of organs such as lung, heart, blood vessels, kidney and the like caused by coronavirus pneumonia (including 2019-nCoV). Specifically, the compound provided by the invention has the following preferable structure as shown in the specification.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to a kind of dithiobibutyrol and its analogues in the preparation of medicines for the prevention and / or treatment of lung, heart, blood vessel, kidney and other organ damage diseases caused by coronavirus pneumonia (including COVID-19) the use of. Background technique [0002] Coronavirus is a common animal virus that can be carried by many common domestic animals or wild animals. Some of these viruses have the ability to infect humans due to evolution or mutation. Currently, there are 7 coronaviruses that have been confirmed to have the ability to infect humans. Among them, the 2019 novel coronavirus (2019-nCoV, which causes COVID-19) is the seventh known coronavirus that can infect humans. [0003] At present, most of the understanding of the physical and chemical characteristics of coronavirus comes from the research of SARS-CoV and MERS-CoV. Viruses are sensitive to ultraviole...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/10A61P31/14A61P11/00A61P9/00A61P13/12A61P1/16A61P9/04A61P7/04A61P7/08
CPCA61K31/10A61P31/14A61P11/00A61P9/00A61P13/12A61P1/16A61P9/04A61P7/04A61P7/08
Inventor 田方一李体茂田飞
Owner 北京中美红格科技有限公司
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