Application of dithiobibutyl phenol and analogue in prevention and treatment of organ injury diseases caused by coronavirus pneumonia (including COVID-19)
A kind of coronavirus, the technology of use, applied in the field of medicine, can solve the problems of cell damage, membrane fluidity change, membrane function loss, etc., and achieve the effect of eliminating symptoms, changing high passability, and inhibiting serious damage to organs
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Embodiment 1
[0045] Embodiment 1. The activity test of compound of the present invention to SOD
[0046] Experimental principle and model establishment:
[0047] Doxorubicin can induce excessive production of reactive oxygen species (ROS), and is closely related to the increase of cellular oxidative stress. The compound of the present invention is tested and found that the compound of the present invention can alleviate the effect of doxorubicin on intracellular GSH-Px ( Glutathione peroxidase-) and the inhibition of SOD activity are also accompanied by the reduction of ROS and lipid peroxidation product MDA induced by doxorubicin. These results suggest that the compound of the present invention is especially 4,4'-( Methylenedisulfide)bis(2,6-di-tert-butylphenol) showed activity on superoxide dismutase bioenzyme activity-inducing target It has higher specificity and human endogenous peptide chains, protein rearrangement and aggregation.
Embodiment 2
[0048] Embodiment 2. The in vivo pharmacokinetic test of compound of the present invention
[0049] Experimental results show that the compound of the invention has good pharmacokinetic properties and is suitable for making medicines.
Embodiment 3
[0050] Example 3. Activity test of compounds of the present invention for in vivo cell damage
[0051] Cell injury model: The pathological model is established by causing cell injury in animals in vivo by the chemotherapeutic drug doxorubicin.
[0052] The experimental results shown in Table 1 below show that the compound of the present invention can effectively protect against cell damage, wherein the compound is selected from 4,4'-(methylene disulfide)bis(2,6-di-tert-butylphenol).
[0053] Table 1
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[0055]
[0056] Table 1 - continued a
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[0058]
[0059] Table 1 - continued b
[0060]
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