Bionic extracellular matrix bioactive substance coated polyester reticular lamellar stent

Abstract

The invention provides a bionic extracellular matrix bioactive substance coated polyester reticular lamellar stent, which comprises a surface carboxylated reticular lamellar layer and a bioactive substance coating layer covering the surface of the polyester reticular lamellar layer; the reticular lamellar layer is made of a polyester material; the bioactive substance coating layer is formed by coupling the reticular lamellar layer for multiple times; and a sealing layer is further arranged outside the bioactive substance coating layer. According to the invention, the advantages of certain mechanical property and plasticity of a synthetic polyester high polymer material are combined with good biocompatibility of a natural high polymer material, such that the stent in the invention not only has certain mechanical strength and good biocompatibility, but also provides a bionic culture environment for cell culture.

Description

technical field [0001] The present application relates to the technical field of tissue engineering, in particular to a bionic extracellular matrix bioactive substance-coated polyester mesh sheet scaffold. Background technique [0002] Physiological activities such as cell proliferation, differentiation, and metabolism are seriously affected by the regulation of the microenvironment. A bioreactor is a bioreactor for large-scale production of cells or for large-scale production of cells or for harvesting cell culture products. Among them, anchorage-dependent cells mainly add scaffold materials to the reactor to provide a cell growth surface, and realize high-density cell culture through the high specific surface area of ​​the material. [0003] At present, commonly used scaffold materials in bioreactors mainly include microcarriers Cytodex, Cytopore microcarriers, and fibrous scaffolds. Cytodex, a microcarrier attached to the cell surface, is a spherical two-dimensional cell...

AI Technical Summary

Problems solved by technology

The reactor culture mode based on Cytopore microcarrier is stirring type. Although this porous structure can reduce the damage of shear force to cells to a certain extent, it cannot fundamentally eliminate the influence of shear force on cells.

Fibrous scaffolds such as FibraDisk carriers have certain mechanical strength and good mechanical properties, and can realize the three-dimensional culture structure of cells in vitro. However, the biocompatibility of pure polymer materials still has a certain gap compared with natural extracellular matrix components. defect

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