Hydrogel of lubricating coating, preparation method of hydrogel, hydrogel freeze-dried powder and application of hydrogel freeze-dried powder

A technology of hydrogel and freeze-dried powder, which is applied in medical science, surgery, etc., to achieve the effect of not being easily damaged, good lubricating performance, and preventing inflammatory reactions

Pending Publication Date: 2021-09-24
INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention proposes a lubricating coating hydrogel and its preparation method, hydrogel freeze-dried powder and application, to solve one or more technical problems existing in the prior art, and at least provide a beneficial choice or creation condition

Method used

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  • Hydrogel of lubricating coating, preparation method of hydrogel, hydrogel freeze-dried powder and application of hydrogel freeze-dried powder
  • Hydrogel of lubricating coating, preparation method of hydrogel, hydrogel freeze-dried powder and application of hydrogel freeze-dried powder

Examples

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Effect test

Embodiment 1

[0040] A hydrogel, the preparation raw material of the hydrogel includes N-isopropylacrylamide, chitosan and polyvinylpyrrolidone.

[0041] A method for preparing a hydrogel, comprising the steps of:

[0042] Chitosan was dissolved in an acidic aqueous solution to prepare a homogeneous solution A with a mass concentration of 1%. The acidic aqueous solution was an aqueous hydrochloric acid solution with a pH value of 2.

[0043] Dissolve N-isopropylacrylamide in deionized water to make a solution B with a mass concentration of 10%, and add a mass concentration of 0.5% to the solution B. The initiator 2-hydroxyl-4'-(2-hydroxyl Ethoxy)-2-methylpropiophenone and a crosslinking agent N,N-dimethylbisacrylamide with a mass concentration of 1% were stirred, dissolved and mixed evenly to obtain solution C;

[0044] After mixing the solution A and the solution C, add polyvinylpyrrolidone with a mass concentration of 10% therein, and stir thoroughly to form a uniform solution D;

[004...

Embodiment 2

[0048]A hydrogel, the preparation raw material of the hydrogel includes N-isopropylacrylamide, carboxymethyl chitosan and polyvinylpyrrolidone.

[0049] A method for preparing a hydrogel, comprising the steps of:

[0050] Dissolve carboxymethyl chitosan in deionized water to prepare a homogeneous solution A with a mass concentration of 2%.

[0051] Dissolve N-isopropylacrylamide in deionized water to make a solution B with a mass concentration of 10%, and add a mass concentration of 1% initiator 4-phenylbenzophenone and a mass concentration of It is 1% cross-linking agent N,N-dimethylbisacrylamide, stirred and dissolved and mixed evenly to obtain solution C;

[0052] After mixing the solution A and the solution C, add polyvinylpyrrolidone with a mass concentration of 15% therein, and stir thoroughly to form a uniform solution D;

[0053] The solution D was exposed to ultraviolet light for 10 minutes to obtain a hydrogel.

[0054] A hydrogel freeze-dried powder, which is obt...

Embodiment 3

[0056] A hydrogel, the preparation raw material of the hydrogel includes acrylamide, chitosan quaternary ammonium salt and polyvinylpyrrolidone.

[0057] A method for preparing a hydrogel, comprising the steps of:

[0058] Chitosan quaternary ammonium salt was dissolved in deionized water to prepare a uniform solution A with a mass concentration of 3%.

[0059] Dissolve acrylamide in deionized water to make a solution B with a mass concentration of 20%, and add a mass concentration of 1% initiator camphoroporone and a mass concentration of 1% crosslinking agent N,N- Dimethylbisacrylamide was stirred, dissolved and mixed evenly to obtain solution C;

[0060] After mixing the solution A and the solution C, add polyvinylpyrrolidone with a mass concentration of 25% to it, and stir thoroughly to form a uniform solution D;

[0061] The solution D was exposed to ultraviolet light for 15 minutes to obtain a hydrogel.

[0062] A hydrogel freeze-dried powder, obtained by grinding the...

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Abstract

The invention relates to the technical field of high polymer materials, and particularly discloses a hydrogel and a preparation method and application of freeze-dried powder of the hydrogel, and preparation raw materials of the hydrogel comprise acrylamide substances, chitosan substances and polyvinylpyrrolidone. The preparation method of the hydrogel comprises the following steps: preparing a chitosan substance into a solution A; preparing an acrylamide substance into a solution B with the mass concentration of 5-30%, adding an initiator and a cross-linking agent into the solution B, and mixing to obtain a solution C; mixing the solution A and the solution C, and adding polyvinylpyrrolidone with the mass concentration of 5-20% to obtain a solution D; and irradiating the solution D with ultraviolet light to obtain the hydrogel, and freeze-drying and grinding the hydrogel to obtain the hydrogel freeze-dried powder. The hydrogel has a double-network structure, is high in gel strength, is not easy to damage when being used for lubricating the interventional medical catheter, is small in friction coefficient, has good lubricity, and can be used for the medical interventional catheter or a medical interventional instrument.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a lubricating coating hydrogel, a preparation method thereof, hydrogel freeze-dried powder and application thereof. Background technique [0002] With the emergence of diversification and complexity of medical diseases and the development of medical level, interventional therapy is increasing in clinical treatment, and many interventional devices rub against the contacted tissue, making it difficult for the device to reach the target patient site or the contacted tissue adverse consequences such as injury. In order to avoid the risk problems caused by interventional devices, hydrophilic lubricating coatings have been more and more widely used in medical interventional devices. The existing disclosed technology of hydrophilic lubricating coatings for medical interventional devices has problems such as complex preparation process, high cost, unsatisfactory durability and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L51/02C08L39/06C08F251/00C08F220/54C08F222/38A61L31/04A61L31/16A61L31/14
CPCC08L51/02C08L39/06C08F251/00A61L31/16A61L31/145A61L31/041A61L2300/452C08F220/54C08F222/385C08F220/56
Inventor 耿志杰于珊张锦
Owner INST OF MEDICINE & HEALTH GUANGDONG ACAD OF SCI
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