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Zinc germanate matrix sustained-released antibacterial nano material capable of monitoring afterglow light and preparation method thereof

A nanomaterial, zinc germanate technology, applied in luminescent materials, nanotechnology for materials and surface science, antibacterial drugs, etc., can solve the problems of difficult real-time monitoring of antibacterial process, difficult treatment of infected parts, chronic wounds, etc. To achieve the effect of pollution-free preparation process, wide application range and low cost

Active Publication Date: 2021-09-24
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, although some smart wound dressings developed through integrated sensors can treat infected wounds by real-time monitoring of wound temperature, pH, blood oxygen level and body fluid markers, etc. The antibacterial process in the complex biological environment of the infection site is difficult to achieve real-time monitoring, which brings certain difficulties to the follow-up and timely further treatment of the infection site
If the bacteria are not eradicated in time, the infected site may develop into a chronic wound, and there is even a risk of amputation and death

Method used

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  • Zinc germanate matrix sustained-released antibacterial nano material capable of monitoring afterglow light and preparation method thereof
  • Zinc germanate matrix sustained-released antibacterial nano material capable of monitoring afterglow light and preparation method thereof
  • Zinc germanate matrix sustained-released antibacterial nano material capable of monitoring afterglow light and preparation method thereof

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Experimental program
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Embodiment 1

[0052] A preparation method of a zinc germanate matrix antibacterial nanomaterial, the preparation steps are as follows:

[0053] (1) Ge 4+ Preparation of ammonia solution: GeO 2 Add the powder into water to disperse evenly by ultrasonic and stir, add ammonia water with a mass percentage concentration of 28% drop by drop until the powder is completely dissolved, and set the volume to 0.4mol L -1 Ge 4+ Ammonia solution;

[0054] (2)Zn(NO 3 ) 2 Preparation of aqueous solution: Zn(NO 3 ) 2 ·6H 2 O solid is mixed with ultrapure water and stirred until the solid is completely dissolved and constant volume is obtained to obtain a solution of the desired concentration;

[0055] (3)Cu(NO 3 ) 2 Preparation of aqueous solution: Cu(NO 3 ) 2 ·3H 2 O solid is mixed with ultrapure water and stirred until the solid is completely dissolved and constant volume is obtained to obtain a solution of the desired concentration;

[0056] (4) Zn (NO 3 ) 2 Aqueous solution, the Cu(NO th...

Embodiment 2

[0067] (1) with embodiment 1;

[0068] (2) with embodiment 1;

[0069] (3) with embodiment 1;

[0070] (4) Zn (NO 3 ) 2 Aqueous solution, the Cu(NO that step (3) obtains 3 ) 2 Aqueous solution, 0.3mL of concentrated nitric acid was added to 11mL of ultrapure water, stirred and mixed evenly, and the Ge obtained in step (1) was added dropwise. 4+ Ammonia solution, where Zn 2+ 、 Ge 4+ 、Cu 2+ The molar ratio is 2:1:0.005, the pH value of the mixed solution is adjusted to 9.0 with ammonia water with a mass percentage concentration of 28%, the reaction solution is placed in an ultrasonic cleaner for 10 minutes, and then magnetically stirred at room temperature for 1 hour;

[0071] (5) Transfer the mixed solution obtained in step (4) to a stainless steel autoclave lined with polytetrafluoroethylene, and react in an oven at 160° C. for 8 hours;

[0072] (6) with embodiment 1;

[0073] (7) with embodiment 1.

Embodiment 3

[0075] (1) with embodiment 1;

[0076] (2) with embodiment 1;

[0077] (3) with embodiment 1;

[0078] (4) Zn (NO 3 ) 2 Aqueous solution, the Cu(NO that step (3) obtains 3 ) 2 Aqueous solution, 0.3mL of concentrated nitric acid was added to 11mL of ultrapure water, stirred and mixed evenly, and the Ge obtained in step (1) was added dropwise. 4+ Ammonia solution, where Zn 2+ 、 Ge 4+ 、Cu 2+The molar ratio is 2:1:0.01, the pH value of the mixed solution is adjusted to 9.0 with ammonia water with a mass percentage concentration of 28%, the reaction solution is placed in an ultrasonic cleaner for 10 minutes, and then magnetically stirred at room temperature for 1 hour;

[0079] (5) Transfer the mixed solution obtained in step (4) to a stainless steel autoclave lined with polytetrafluoroethylene, and react in an oven at 120°C for 24 hours;

[0080] (6) with embodiment 1;

[0081] (7) with embodiment 1.

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Abstract

The invention discloses a zinc germanate matrix sustained-released antibacterial nano material capable of monitoring afterglow light and a preparation method thereof, and belongs to the field of preparation of antibacterial nano materials. The chemical composition general formula of the zinc germanate matrix antibacterial nano material is Zn2GeO4: xM, x is greater than or equal to 0.001 and less than or equal to 0.02, Zn2GeO4 is a matrix, and M is a metal ion with an antibacterial effect. The zinc germanate matrix antibacterial nano material is synthesized by a hydrothermal method, is simple to prepare and low in cost, and can be used for industrial production; the material has excellent broad-spectrum antibacterial performance at a bacterial infection part, metal ion slow release can maintain high antibacterial concentration for a long time, the antibacterial period is long, and the possibility of inducing bacteria to generate drug resistance is extremely low; and in a subacid environment of a bacterial infection part, the afterglow light intensity of the material changes along with degradation of the material, and real-time monitoring of the antibacterial process of the infection part can be realized by utilizing the change of the afterglow intensity.

Description

technical field [0001] The invention relates to a zinc germanate matrix nano material capable of monitoring slow-release antibacterial by afterglow and a preparation method thereof, belonging to the field of antibacterial nano material preparation. Background technique [0002] Bacterial infection has become one of the largest public health problems in the world, and millions of people die from bacterial infection every year. Since the discovery of penicillin in 1982, various antibiotics have been developed and widely and continuously used to deal with bacterial infections. The excessive use of antibiotics has led to the emergence of drug resistance in bacteria, resulting in multi-drug resistant bacteria and even superbugs. Since the peak period of research and development in the 1980s, the speed of research and development of antibiotics has slowed down year by year, and only a handful of new antibiotics have been approved after 2000, which has put enormous pressure on the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/02A61K49/00A61K33/06A61K33/24A61K33/26A61K33/32A61K33/34A61K33/38A61P17/02A61P31/04B82Y5/00B82Y20/00B82Y30/00B82Y40/00C09K11/58
CPCC09K11/584A61K9/143A61K47/02A61K49/0015A61K49/0093A61K33/38A61K33/34A61K33/24A61K33/26A61K33/32A61K33/06A61P31/04A61P17/02B82Y5/00B82Y20/00B82Y30/00B82Y40/00Y02A50/30
Inventor 陈丽建严秀平龚嘉华王江悦刘瑶瑶
Owner JIANGNAN UNIV
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